Ca-125: A Useful Marker to Distinguish Pulmonary Tuberculosis from Other Pulmonary Infections

Fortün, Jesús; Martín-Dávila, Pilar; Méndez, Raúl; Martínez, A. Pérez; Norman, Francesca; Rubı́, J. M.; Pallarés, Esperanza; Gómez-Mampaso, E; Moreno, Santiago

doi:10.2174/1874306400903010123

Cited by 130 publications

(23 citation statements)

References 27 publications

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“…In 10 of the patients with pulmonary tuberculosis, measurements were repeated a er two to four months of treatment and serum levels decreased. e cut-o level for pulmonary tuberculosis cases was determined to be 32.5 IU/mL [35], comparable to that found in our study (36.35 IU/mL).…”

Section: Discussionsupporting

confidence: 86%

Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment

Şahin

Yıldız²

2012

CIM

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Purpose: CA-125 is a high molecular weight mucin-like glycoprotein and an ovarian cancer antigen. Elevated CA-125 levels are also seen with various other benign and malignant conditions. In this study, the ability of CA-125 to predict pulmonary tuberculosis activity was investigated. Methods: This analytical study included 42 cases with active tuberculosis (Group 1), 35 cases with inactive tuberculosis (Group 2) and 20 healthy subjects (Group 3). CA-125 measurements were taken in all three groups. Measurements in Group 1 were repeated after completing a two month anti-tuberculosis treatment in 38 of the 42 patients. Results: Mean serum CA-125 level for Group 1 was 76.48±24.71 U/mL, which was significantly higher than levels in Group 2 (20.01±7.89 U/mL) and Group 3 (18.32±2.87 U/mL) (p < 0.001). Of the 38 patients in Group 1 who were studied both pre- and post-treatment, CA-125 levels decreased significantly: from 78.88±24.72 U/mL before treatment to 22.78±8.02 U/mL after treatment (p < 0.001). There was no statistically significant difference between the post-treatment values of Group 1 and either Group 2 and Group 3 values (p > 0.05). Group 2 and Group 3 levels were not significantly different (p > 0.05). The cut-off level for accurate determination of activity was 36.35 U/mL. The sensitivity at this level was 97.6% and specificity was 100%. Conclusion: Our findings suggest that CA-125 can be a beneficial parameter in determination of pulmonary tuberculosis activity and the evaluation of response to treatment.

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Section: Discussionsupporting

confidence: 86%

Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment

Şahin

Yıldız²

2012

CIM

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“…This review was performed according to the PRISMA guidelines [10], thus providing a comprehensive framework which objectively assesses indicators of quality and risk of biases of included studies.…”

Section: Methodsmentioning

confidence: 99%

Smoking and antidepressants pharmacokinetics: a systematic review

et al. 2017

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BackgroundDespite an increasingly recognized relationship between depression and smoking, little is known about how smoking influences antidepressant response and treatment outcomes. The aim of this study was to systematically review the evidence of the impact of smoking on new-generation antidepressants with an emphasis on the pharmacokinetic perspective.MethodsWe present a systematic review of clinical trials comparing the serum levels of new-generation antidepressants in smokers and nonsmokers. Data were obtained from MEDLINE/PubMed, Embase, and other sources. Risk of bias was assessed for selection, performance, detection, attrition, and reporting of individual studies.ResultsTwenty-one studies met inclusion criteria; seven involved fluvoxamine, two evaluated fluoxetine, sertraline, venlafaxine, duloxetine or mirtazapine, and escitalopram, citalopram, trazodone and bupropion were the subject of a single study. No trials were found involving other common antidepressants such as paroxetine or agomelatine. Serum levels of fluvoxamine, duloxetine, mirtazapine and trazodone were significantly higher in nonsmokers compared with smokers.ConclusionsThere is evidence showing a reduction in the concentration of serum levels of fluvoxamine, duloxetine, mirtazapine and trazodone in smoking patients as compared to nonsmokers. The evidence regarding other commonly used antidepressants is scarce. Nonetheless, smoking status should be considered when choosing an antidepressant treatment, given the risk of pharmacokinetic interactions.

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“…Serum CA-125 (tumor marker) level was elevated (164.3 ku/L; normal level, 35 ku/L) [3]. Electrocardiogram showed sinus rhythm.…”

Section: Case Presentationmentioning

confidence: 99%

A rare case of biventricular myxoma

Ermek

Aybek

Zhang

et al. 2017

J Cardiothorac Surg

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BackgroundCardiac myxoma is the most common primary cardiac tumor. Approximately 75–80% of myxomas are located in the left atrium. Occurrence of multiple myxomas is extremely rare.Case presentationWe describe a rare case of biventricular myxomas resulting in right ventricular inflow and tricuspid valve obstruction. The lesions were detected by echocardiography and thoracic computerized tomography (CT) and confirmed on positron emission tomography–computed tomography.ConclusionThe patient underwent successful surgical resection of the multiple cardiac myxomas. This kind of biventricular case has not been previously reported. The patient is asymptomatic as of the 10-month follow-up.

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Ca-125: A Useful Marker to Distinguish Pulmonary Tuberculosis from Other Pulmonary Infections

Cited by 130 publications

References 27 publications

Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment

Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment

Smoking and antidepressants pharmacokinetics: a systematic review

A rare case of biventricular myxoma

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