CA 125 and its relation to cardiac function

Nägele, Herbert; Bahlo, M.; Klapdor, R; Schaeperkoetter, Dorothea; Rödiger, W

doi:10.1016/s0002-8703(99)70360-1

Cited by 108 publications

(129 citation statements)

References 11 publications

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“…Indirect evidence that elevated Ca 125 levels in patients with HF are not only related to volume overload was provided by the study by D'Aloia et al who showed that an increase in Ca 125 level was seen both in patients with effusion and those without effusion [12]. A similar relation was reported by Nagele et al [25]. Another study showed a significant relation between Ca 125 level and left ventricular end-diastolic pressure and BNP level, the latter being produced mainly in response to increase left ventricular wall strain and volume overload [11].…”

Section: (37)supporting

confidence: 52%

Wartość oznaczania stężeń antygenu nowotworowego Ca 125 i kopeptyny w monitorowaniu terapii chorych z zaawansowaną niewydolnością serca

et al. 2017

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Section: (37)supporting

confidence: 52%

Wartość oznaczania stężeń antygenu nowotworowego Ca 125 i kopeptyny w monitorowaniu terapii chorych z zaawansowaną niewydolnością serca

et al. 2017

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“…Numerous studies showed increased CA125 levels in CHF patients and a relationship between these values and HF severity [5][6][7][8][9][10][11][12][13][14][15]. In the present study, we investigated the prognostic value of CA125 levels in an AHF population.…”

Section: Discussionmentioning

confidence: 99%

“…Carbohydrate antigen 125 (CA125) is a tumour marker classically associated with ovarian cancer [4]; recently several studies reported increased serum CA125 levels in HF patients [5][6][7][8][9][10][11][12][13][14][15]. However, it is still a matter of debate if CA125 is a potential prognostic marker for AHF and also if it is useful for evaluating and managing pre-transplant patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of CA125 in advanced heart failure patients

Monteiro

Franco

Costa

et al. 2010

International Journal of Cardiology

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Introduction: Serum levels of CA125 are often high in advanced heart failure (AHF) patients. Aim: To determine the predictive value of CA125 in forecasting the occurrence of death or cardiac transplantation in an AHF population. Methods: 88 AHF patients referred for heart transplantation were divided into 2 groups based on CA125 levels: normal (CA125 b 38 U/mL) and elevated (≥ 38 U/mL). Events (death or heart transplant) were monitored over a period of 13 ± 7 months after CA125 determination. Results: Patients with elevated CA125 (n = 65) had significantly lower blood pressure, body mass index, serum sodium and peak exercise oxygen consumption, while B-type natriuretic peptide levels were significantly higher. The combined primary endpoint (death or heart transplant) rate was 39.4% and 62.3% in normal and elevated CA125 groups, respectively (p = 0.029). Multivariate regression analysis showed that CA125 and sodium levels were the only independent predictors of the combined endpoint. Conclusion: In AHF patients, plasma CA125 was an effective prognostic marker. Its determination may contribute to better risk stratification in this population.

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“…The first study investigating possible clinical and hemodynamic associations of tumor markers with chronic HF was published by Nagele et al 16 The authors investigated various tumor markers in patients with severe HF both before and after cardiac transplantation and showed a direct correlation between CA 125 levels and right atrial pressure (r ¼ 0.41, p ¼ 0.0001) and pulmonary capillary wedge pressure (r ¼ 0.27, p ¼ 0.001). They also demonstrated an increase in serum CA 125 levels in both advanced HF patients with possible fluid accumulation and mild HF patients with no expected serosal effusion compared with healthy controls.…”

Section: Discussionmentioning

confidence: 99%

CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

et al. 2013

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Purpose: The aim of this study was to analyze associations between serum cancer antigen 125 (CA 125) levels and left ventricular (LV) function in patients with end-stage renal disease on maintenance hemodialysis (HD). Methods: CA 125 levels, pro-brain natriuretic peptide (pro-BNP) and biochemical parameters were measured, and echocardiography was performed for 110 patients and 47 healthy controls. Results: The mean CA 125 level in patients, 38.78 AE 35.48 U/ mL, was significantly higher than that found in healthy controls (9.20 AE 4.55 U/mL; p ¼ 0.003). Patients with elevated CA 125 levels (n ¼ 40) had significantly lower levels of albumin and reduced relative wall thickness, LV ejection fraction (EF) and fractional shortening but significantly higher levels of pro-BNP and a greater left ventricular end-diastolic diameter (LVEDd) and -systolic diameter (LVESd). CA 125 levels were positively correlated with pro-BNP (r ¼ 0.596, p50.05) and C-reactive protein (CRP) levels (r ¼ 0.439, p50.05), as well as LVEDd (r ¼ 0.599, p50.001), LVESd (r ¼ 0.750, p50.001) and LV mass index (r ¼ 0.378, p50.05). In contrast, serum CA 125 levels were negatively correlated with albumin (r ¼ À0.513, p50.05) and hemoglobin (r ¼ À0.475, p50.05) as well as the EF (r ¼ À0.878, p50.0001). A depressed EF ( ¼ À1.121, p50.0001) and increased CRP levels ( ¼ 0.247, p ¼ 0.035) were independent predictors of high CA 125 levels in the whole group in the multivariate-model. Conclusions: Our study is the first to demonstrate an association between serum CA 125 levels and LV systolic dysfunction via inflammation in patients on maintenance HD.

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CA 125 and its relation to cardiac function

Cited by 108 publications

References 11 publications

Wartość oznaczania stężeń antygenu nowotworowego Ca 125 i kopeptyny w monitorowaniu terapii chorych z zaawansowaną niewydolnością serca

Wartość oznaczania stężeń antygenu nowotworowego Ca 125 i kopeptyny w monitorowaniu terapii chorych z zaawansowaną niewydolnością serca

Prognostic value of CA125 in advanced heart failure patients

CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

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