CA 19-9 to peritoneal carcinomatosis index (PCI) ratio is prognostic in patients with epithelial appendiceal mucinous neoplasms and peritoneal dissemination undergoing cytoreduction surgery and intraperitoneal chemotherapy

Kozman, Mathew A.; Fisher, Oliver M.; Rebolledo, Bree-Anne J.; Valle, Sarah J.; Alzahrani, Nayef; Liauw, Winston; Morris, David L.

doi:10.1016/j.ejso.2017.09.009

Cited by 20 publications

(14 citation statements)

References 20 publications

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“…Although neither of these markers was determined to be an independent risk factor in our study due to the limited number of patients, it appeared that CA125 and CA199 may be predictive for survival and could be risk factors, if more cases were included in the future. We also found that PCI may be capable for predicting the survival of PMP that originated in the ovary, which was consistent with previous observations reported for PMP that originated in the appendix 28‐34 . Therefore, PCI might be able to predict the survival of patients with PMP originating in the ovary.…”

Section: Discussionsupporting

confidence: 91%

“…Previous observations suggest that pre‐therapeutic levels of CA199 and CEA were able to predict the survival of patients with appendix‐originating PMP 27‐33 . CA199 was also determined to be an independent risk factor for PMP originating from the appendix 29‐33 .…”

Section: Discussionmentioning

confidence: 81%

“…[27][28][29][30][31][32][33] CA199 was also determined to be an independent risk factor for PMP originating from the appendix. [29][30][31][32][33] Our study suggested that CA125 and CA199 were also markers with predicting capabilities for ovary-originating PMP. The cases of patient of death were all in one group with respect to assessments of presurgery and postsurgery blood with respect to the levels of CA125.…”

Section: Discussionmentioning

confidence: 98%

“…We also found that PCI may be capable for predicting the survival of PMP that originated in the ovary, which was consistent with previous observations reported for PMP that originated in the appendix. [28][29][30][31][32][33][34] Therefore, PCI might be able to predict the survival of patients with PMP originating in the ovary.…”

Section: Discussionmentioning

confidence: 99%

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The mutational landscape and prognostic indicators of pseudomyxoma peritonei originating from the ovary

Wang

Yao²,

et al. 2021

Intl Journal of Cancer

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Pseudomyxoma peritonei (PMP) is a rare disorder with unique pathological and genetic changes. Although several studies have reported the clinical features and mutational changes of PMP that originates from the appendix, few studies on PMP originating from the ovary have been reported due to its extreme rarity. In order to characterize the somatic mutational landscape and to investigate the prognosis predicting factors of ovary‐originating PMP, we examined 830 cases of PMP and identified 16 patients with PMP that originated from the ovary. Whole‐exome sequencing (WES) was performed on 12 cases using formalin‐fixed, paraffin‐embedded (FFPE) tissue samples. We found that 25% (3/12) of the patients carried mutations in cancer driver genes, including TP53, ATM and SETD2, and 16.7% (2/12) of the patients carried mutations in cancer driver genes, including ATRX, EP300, FGFR2, KRAS, NOCR1 and RB1. The MUC16 (58.33%), BSN (41.67%), PCNT (41.67%), PPP2R5A (41.67%), PRSS36 (41.67%), PTPRK (41.67%) and SBF1 (41.67%) genes presented the highest mutational frequencies. The PI3K‐Akt signaling pathway, human papillomavirus infection pathway, cell skeleton, cell adhesion, and extracellular matrix and membrane proteins were the major pathways or functions that were affected. Patients were followed up to 174 months (median: 48.26 months). The 5‐year OS rate for all patients was 71.2% and the median OS was not reached. PTPRK mutations, presurgical CA199 level, completeness of cytoreduction (CCR) and peritoneal cancer index (PCI) were identified as potential predictive factors for patient survival. In conclusion, the mutational landscape for ovary‐originating PMP was revealed and exhibited unique features distinct from appendix‐originating PMP. PTPRK, CA199, CCR and PCI may predict patient survival.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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The mutational landscape and prognostic indicators of pseudomyxoma peritonei originating from the ovary

Wang

Yao²,

et al. 2021

Intl Journal of Cancer

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“…Levels of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19‐9 and cancer antigen 125 (CA125) may be raised in these patients. Some studies have shown that increase in one or more of these tumour markers may be associated with worse prognosis.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing long‐term survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei originating from appendiceal neoplasms

et al. 2019

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Background Pseudomyxoma peritonei (PMP) is a rare disease, most commonly of appendiceal origin. Treatment consists of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS–HIPEC). The aim of this study was to identify prognostic factors for recurrence and survival. Methods This was an observational study using a prospectively designed database containing consecutive patients with PMP originating from the appendix, undergoing CRS–HIPEC at a tertiary referral centre between 1996 and 2015. Histopathological slides were reassessed. Cox regression was used for multivariable analyses. Results Of 225 patients identified, 36 (16·0 per cent) were diagnosed with acellular mucin, 149 (66·2 per cent) had disseminated peritoneal adenomucinosis (DPAM) and 40 (17·8 per cent) had peritoneal mucinous carcinomatosis (PMCA). The 5‐year overall survival (OS) rates were 93, 69·8 and 55 per cent respectively. Recurrence was observed in 120 patients (53·3 per cent), 39 of whom (17·3 per cent) were treated with a second CRS–HIPEC procedure. Factors independently associated with poor disease‐free survival were six or seven affected regions (hazard ratio (HR) 6·01, 95 per cent c.i. 2·04 to 17·73), incomplete cytoreduction (R2a resection: HR 1·67, 1·05 to 2·65; R2b resection: HR 2·00, 1·07 to 3·73), and more than threefold raised carcinoembryonic antigen (CEA) and/or carbohydrate antigen (CA) 19‐9 level (HR 2·31, 1·30 to 4·11). Factors independently associated with poorer OS were male sex (HR 1·74, 1·09 to 2·77), incomplete cytoreduction (R2a resection: HR 1·87, 1·14 to 3·08; R2b resection: HR 2·28, 1·19 to 4·34), and more than threefold raised CEA and/or CA19‐9 level (HR 2·89, 1·36 to 6·16). Conclusion CEA and CA19‐9 levels raised more than threefold above the upper limit identify patients with PMP of appendiceal origin and poorer survival.

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The Utility of Preoperative Tumor Markers in Peritoneal Carcinomatosis from Primary Appendiceal Adenocarcinoma: an Analysis from the US HIPEC Collaborative

Fackche

Schmocker

Kubi

et al. 2021

Journal of Gastrointestinal Surgery

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CA 19-9 to peritoneal carcinomatosis index (PCI) ratio is prognostic in patients with epithelial appendiceal mucinous neoplasms and peritoneal dissemination undergoing cytoreduction surgery and intraperitoneal chemotherapy

Cited by 20 publications

References 20 publications

The mutational landscape and prognostic indicators of pseudomyxoma peritonei originating from the ovary

The mutational landscape and prognostic indicators of pseudomyxoma peritonei originating from the ovary

Factors influencing long‐term survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei originating from appendiceal neoplasms

The Utility of Preoperative Tumor Markers in Peritoneal Carcinomatosis from Primary Appendiceal Adenocarcinoma: an Analysis from the US HIPEC Collaborative

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