2016
DOI: 10.1016/j.ceca.2015.12.003
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Ca2+ coding and decoding strategies for the specification of neural and renal precursor cells during development

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Cited by 18 publications
(14 citation statements)
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References 109 publications
(112 reference statements)
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“…Cav1.2 channels are important regulators of calcium signaling and gene expression in the developed brain (Ma et al, 2012) that are also critical to brain development, being differentially expressed (both spatially and temporally) in the central nervous system across vertebrate embryonic development (Lewis et al, 2009;Moreau et al, 2016). The TS2-neo mouse is heterozygous for a global gain function mutation in Cav1.2 that would also be present throughout embryonic development, and disrupted calcium signaling in this mouse model has the potential to alter brain development beginning at early embryonic stages.…”
Section: Discussionmentioning
confidence: 99%
“…Cav1.2 channels are important regulators of calcium signaling and gene expression in the developed brain (Ma et al, 2012) that are also critical to brain development, being differentially expressed (both spatially and temporally) in the central nervous system across vertebrate embryonic development (Lewis et al, 2009;Moreau et al, 2016). The TS2-neo mouse is heterozygous for a global gain function mutation in Cav1.2 that would also be present throughout embryonic development, and disrupted calcium signaling in this mouse model has the potential to alter brain development beginning at early embryonic stages.…”
Section: Discussionmentioning
confidence: 99%
“…Embryonic stem cells (ESCs) are isolated from the inner cell mass of the preimplantation embryo. During embryogenesis, elevated intracellular Ca 2+ is needed for ESCs to differentiate towards a specific tissue fate . The expression of L‐VGCCs has been identified in ESCs from humans and mice.…”
Section: L‐vgccs and Embryonic Stem Cellsmentioning
confidence: 99%
“…Similarly, calcium activity is enriched in the frequency of occurrence and amplitude in Blastula Chordin and Noggin-expressing region which is located in dorsal animal cells and presumptive neural tissue in Xenopus and Zebrafish [ 40 , 47 , 49 , 50 , 51 ]. Additionally, a gradual elevation of Ca 2+ in the dorsal quadrant is superimposed at early gastrula stages and continues until late neurula in zebrafish and Xenopus [ 40 , 52 ]. Immunohistochemical assays have shown that newt embryos express various calcium channels, including L-type voltage-gated calcium channels and ryanodine receptors, throughout the presumptive ectoderm during gastrulation.…”
Section: Calcium Activity During Development and Its Role In Diseamentioning
confidence: 99%
“…Calcium activity mediates the initiation and formation of the kidney field; the kidney field is defined as the mesodermal territory where expression of pax8 and lhx1 overlap during organogenesis. Overexpression of pax8 and/or lhx1 leads to the formation of enlarged and ectopic pronephroi [ 52 , 109 ]. In addition, calcium regulates the transcription of genes that are involved in the formation of renal structures, including pax8 , lhx1 , osr1 , and osr2 .…”
Section: Calcium Activity During Development and Its Role In Diseamentioning
confidence: 99%