Background: In this study, different intent prediction strategies were explored with the objective of determining the best approach to predicting continuous multi-axial user motion based solely on surface EMG (electromyography) data. These strategies were explored as the first step to better facilitating control of a multi-axis transtibial powered prosthesis.Methods: Based on data acquired from gait experiments, different data sets, prediction approaches and classification algorithms were explored. The effect of varying EMG electrode positioning was also tested. EMG data measured from three lower leg muscles was the sole data type used for making intent predictions. The motions to be predicted were along both the sagittal plane (foot dorsiflexion and plantarflexion) and the frontal plane (foot eversion and inversion).Results: The deviation of EMG data from its optimal pattern led to a decrease in prediction accuracy of up to 23%. However, using features that were calculated based on a participant's specific walking pattern limited this loss of prediction accuracy as a result of EMG electrode placement. A decoupled data set, one wherein the terrain type was accounted for beforehand, yielded the highest intent prediction accuracy of 77.2%.Conclusions: The results of this study highlighted the challenges faced when using very limited EMG data to predict multi-axial ankle motion. They also indicated that approaches that are more user-centric by design could led to more accurate motion predictions, possibly enabling more intuitive control.