CAD-design, stress analysis and in vitro evaluation of three leaflet blood-pump valves

Knierbein, B.; Rosarius, Norbert; Unger, Alexander; Reul, H.; G, Rau

doi:10.1016/0141-5425(92)90001-2

Cited by 23 publications

(9 citation statements)

References 13 publications

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“…In addition, the tendency for thrombus to develop in miniatured valves and pumps creates the need for the development of a ventricular assist device for infants and neonates [3]. In a clinical trial, we started to apply the new HIAMedos system in selected patients since favorable results from in vitro evaluation and animal experiments were reported [5,7,12,15]. Heretofore there have been no publications about HIA-Medos application in patients.…”

Section: Case Reportmentioning

confidence: 98%

Successful Treatment of Postoperative Right Ventricular Heart Failure with the HIA-Medos-Assist System in a 2-Year-Old Girl

et al. 1999

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One year after total correction of tetralogy of Fallot, reoperation was performed in a 2-year-old infant because of an aneurysm of the right ventricular outflow tract. After removal of the aneurysm, massive right ventricular failure occurred. Maximal medical inotropic support could not reestablish sufficient right ventricular function. Therefore, it was decided to implant the new HIA-Medos system as a right ventricular assist. In the postoperative period, echocardiographic controls showed increasing contractility of the right ventricle. The assist system was removed after 3 days and the infant was discharged in good condition on the 22nd postoperative day.

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Section: Case Reportmentioning

confidence: 98%

Successful Treatment of Postoperative Right Ventricular Heart Failure with the HIA-Medos-Assist System in a 2-Year-Old Girl

et al. 1999

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“…Material models implemented in previous works for modeling heart valve leaflet tissue mechanics can be generally grouped into four categories: elastic and isotropic [122][123][124][125][126], hyperelastic and isotropic [127][128][129][130], elastic and anisotropic [131][132][133] and hyperelastic and anisotropic [134,135]. There have been models developed to study the role of geometry and a non-uniform leaflet thickness on stress distribution in a porcine valve tissue [136,137].…”

Section: Modeling Of Aortic Heart Valve Leafletmentioning

confidence: 99%

Prosthetic aortic heart valves: Modeling and design

Mohammadi

Mequanint

2011

Medical Engineering & Physics

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“…the developme nt of the HIA-VAD up to 1992 was cond ucte d chiefly w ith th e aid of dive rse com pu ter-based me thods, such as CAD (Computer Aided Design) an d FEM (Finite Eleme nt Meth od ) and a large number of in vitro stud ies (7,8,9, 14). Next to hydrodynam ic performance tes ts, d urability tests of mobil e parts of the pump and biocompatibility studies, the main interest lay in the studies concerning flow mechanics.…”

Section: Apart Fro M a Few Basic Animal Experimental Studies In Coopementioning

confidence: 99%

The MEDOS/HIA System: Development, Results, Perspectives

Reul

1999

Thorac cardiovasc Surg

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The clinical development of the MEDOS/HIA cardiac-assist device was influenced mainly by the results of the concomitant animal experiments. An important step in the development was the novel construction of a three-leaflet blood pump valve, which led to a substantial improvement in the dynamic blood flow of the pump. A modified production technique led to a reduction of thrombotic complications as well as to improved handling during use. The production of different sizes provides access for a large number of patients. The effectiveness of all pump sizes was tested in conclusive animal experiments. Result of transfer to the industry has led to an approved product, which is being handled by an innovative firm. The MEDOS/HIA Cardiac Support Device has been introduced successfully into clinical settings since February 1994 and has been used on 217 patients until the end of 1997.

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CAD-design, stress analysis and in vitro evaluation of three leaflet blood-pump valves

Cited by 23 publications

References 13 publications

Successful Treatment of Postoperative Right Ventricular Heart Failure with the HIA-Medos-Assist System in a 2-Year-Old Girl

Successful Treatment of Postoperative Right Ventricular Heart Failure with the HIA-Medos-Assist System in a 2-Year-Old Girl

Prosthetic aortic heart valves: Modeling and design

The MEDOS/HIA System: Development, Results, Perspectives

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