Cadaver-Kidney Transplant Failures at One Month

Clark, EdwardA.; Terasaki, Paul I.; Opelz, Gerhard; Mickey, M. R.

doi:10.1056/nejm197411212912102

Cited by 78 publications

(9 citation statements)

References 13 publications

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“…In kidney preservation, both in animal experiments and in historical controlled retrospective clinical studies, HMP has been demonstrated to provide better early graft function compared to CS (110,111). In addition, when kidneys retrieved from extended-criteria, marginal, or NHB donors were analyzed, HMP was found to be superior to CS (112)(113)(114)(115)(116).…”

Section: Preservation By Hypothermic Machine Perfusionmentioning

confidence: 99%

Perspectives in Organ Preservation

2007

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Maintaining organ viability after donation until transplantation is critically important for optimal graft function and survival. To date, static cold storage is the most widely used form of preservation in every day clinical practice. Although simple and effective, it is questionable whether this method is able to prevent deterioration of organ quality in the present era with increasing numbers of organs retrieved from older, more marginal, and even non-heart-beating donors. This review describes principles involved in effective preservation and focuses on some basic components and methods of abdominal organ preservation in clinical and experimental transplantation. Concepts and developments to reduce ischemia related injury are discussed, including hypothermic machine perfusion. Despite the fact that hypothermic machine perfusion might be superior to static cold storage preservation, organs are still exposed to hypothermia induced damage. Therefore, recently some groups have pointed at the beneficial effects of normothermic machine perfusion as a new perspective in organ preservation and transplantation.

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Section: Preservation By Hypothermic Machine Perfusionmentioning

confidence: 99%

Perspectives in Organ Preservation

2007

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“…However, by the mid‐1980s the situation had reversed, with the majority of kidneys being preserved by CS. The main reason for this was that large‐scale studies of transplantation outcome (1–4) failed to find any survival advantage for kidneys preserved by MP. Consequently, the disadvantages of MP, that is the need for a machine, consumables, technician and the risk of equipment failure, as compared with the simplicity and low cost of CS, were not justified.…”

mentioning

confidence: 99%

Pulsatile machine perfusion vs. cold storage of kidneys for transplantation: a rapid and systematic review

Wight¹,

Chilcott²,

Holmes³

et al. 2003

Clinical Transplantation

156

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Studies of high methodological quality and sufficient size are required to determine whether machine preservation leads to reduce rates of DGF. Predicted impact on graft survival implies that direct evidence would require a large population followed up over a long period of time. Registry database analysis supported by validation of the link between DGF and graft survival may be preferable and more feasible than randomized controlled trials.

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“…The first clinical attempts in this field were made in the 1960s by Belzer et al . , but they failed to demonstrate superior outcomes compared to SCS . Over the last two decades, however, because of progressive organ shortage and a higher proportion of extended criteria donors (ECD), machine perfusion has re‐emerged.…”

Section: Advances In Organ and Tissue Preservationmentioning

confidence: 99%

Emerging technologies in organ preservation, tissue engineering and regenerative medicine: a blessing or curse for transplantation?

et al. 2019

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Summary Since the beginning of transplant medicine in the 1950s, advances in surgical technique and immunosuppressive therapy have created the success story of modern organ transplantation. However, today more than ever, we are facing a huge discrepancy between organ supply and demand, limiting the potential for transplantation to save and improve the lives of millions. To address the current limitations and shortcomings, a variety of emerging new technologies focusing on either maximizing the availability of organs or on generating new organs and organ sources hold great potential to eventully overcoming these hurdles. These advances are mainly in the field of regenerative medicine and tissue engineering. This review gives an overview of this emerging field and its multiple sub‐disciplines and highlights recent advances and existing limitations for widespread clinical application and potential impact on the future of transplantation.

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Cadaver-Kidney Transplant Failures at One Month

Cited by 78 publications

References 13 publications

Perspectives in Organ Preservation

Perspectives in Organ Preservation

Pulsatile machine perfusion vs. cold storage of kidneys for transplantation: a rapid and systematic review

Emerging technologies in organ preservation, tissue engineering and regenerative medicine: a blessing or curse for transplantation?

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