CADgene: a comprehensive database for coronary artery disease genes

Liu, Hui; Liu, Wei; Liao, Yifang; Cheng, Long; Liu, Qian; Ren, Xiang; Shi, Lisong; Tu, Xin; Wang, Qing Kenneth; Guo, An‐Yuan

doi:10.1093/nar/gkq1106

Cited by 79 publications

(72 citation statements)

References 26 publications

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“…In the past few years, a large number of genes have been implicated in contributing to the development of CAD by genetic association studies [23]. In the present study, we selected six polymorphisms from three common CAD susceptibility genes and investigated their associations with coronary atherosclerosis severity in a Chinese population that had undergone angiography.…”

Section: Discussionmentioning

confidence: 99%

OLR1,PON1andMTHFRGene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population

Liu

et al. 2013

Cell Physiol Biochem

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Aims: To explore the association between six single-nucleotide polymorphisms in OLR1, PON1, MTHFR gene and the angiographical characteristics of coronary atherosclerosis to determine if any of the conventional factors correlate with genetic polymorphisms in the advent of the disease. Methods: We examined rs1801131, rs1801133, rs3736232, rs3736234, rs854563 and rs662 by TaqMan® SNP Genotyping Assays in 1075 subjects that underwent angiography. The angiographical characteristics of coronary atherosclerosis were defined by the Gensini Score system. Results: The T allele of rs1801133 was associated with coronary atherosclerosis severity with the OR = 1.49, 95% CI = 1.04-2.14. In MTHFR gene, haplotype T-A was a susceptibility haplotype to coronary atherosclerosis (OR = 1.27, 95% CI = 1.06-1.51) whereas haplotype C-A had a protective effect (OR = 0.83, 95% CI = 0.70-0.99). In addition, several synergistic effects between rs1801133 and conventional risk factors such as diabetes and smoking were found. Conclusions: Collectively, the results demonstrate that the T allele of rs1801133 conferred an increased risk for coronary atherosclerosis. The MTHFR C-A haplotype was a protective haplotype, while T-A haplotype was a susceptibility haplotype. The presence of the T allele of rs1801133 increases the odds of coronary atherosclerosis severity when associated with conventional risk factors.

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Section: Discussionmentioning

confidence: 99%

OLR1,PON1andMTHFRGene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population

Liu

et al. 2013

Cell Physiol Biochem

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“…A representative number of genes sequences of Coronary Artery Disease Gene Database (CADGD)has been taken in account [32,33]. Indetail, we have selected 60 genes thatare shown in table 1.…”

Section: Methodsmentioning

confidence: 99%

On the fractal analysis of gene sequences involved in atherosclerosis by binary image indicator matrix

Pierro¹

2015

Fractal Geometry and Nonlinear Analysis in Medicine and Biology

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In this paper, the gene sequences involved in Coronary Artery Disease (CAD) were analyzed by fractal analysis. In order to obtain a quantitative characterization of nucleotide patterns and to identify anomalies and singularities belonging to genes, the fractal dimension (FD) and lacunarity were studied as fractal parameters. To obtain accurateparametric values, the Binary Image Indicator Matrix (BIIM) was used. This method converts uni-dimensional sequences into 2-D images preserving the autocorrelation.The results show like the fractal values of genes CAD are very similar to the random sequences. In particular, all FD values fall in the range 1.20 -1.22 highlighting that the complexity/fractality is the same and suggesting that all genes equally contribute to the pathogenesis of atherosclerosis from statistical point a view. These results are in accordance with the biological studies that indicate CAD as a multi-factorial process, so that these values could be considered as characteristics for these genes.

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“…To re-validate the result of the analysis on miRNA-disease association, the online tool g:Profiler [36] was applied to perform GO analysis on the experimentally-validated [37] and literature-reported [23] target genes of each of the 51 dysregulated miRNAs in MI and the highly-confident MI-related genes [38]. In the website of g:Profiler, the minimum and maximum sizes of functional category was set as 5 and 50, respectively.…”

Section: Mirna-disease Association Analysismentioning

confidence: 99%

Functional Network Analysis Reveals Versatile MicroRNAs in Human Heart

Zhu

Sun

et al. 2015

Cell Physiol Biochem

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Background: Acting on many mRNAs allows the power of a single miRNA to modulate multiple pathophysiological phenotypes. One question is whether versatile miRNAs exist in the pathological scenarios of myocardial infarction (MI) and heart failure (HF). Methods: A hypergeometric analysis, in combination with network-based functional analyses, was performed on the available human protein interaction and miRNA-gene association data to highlight versatile miRNAs among the significantly dysregulated miRNAs in MI and HF. In vivo, mice models of MI and HF were then established to investigate whether dysregulated expression be undertaken by versatile miRNA identified here. Results: Systematic analyses really identified the previously validated miRNAs that have been verified of multiple important roles in MI and HF, demonstrating method effectiveness. By using this means, we innovatively revealed the vital role of miR-7 in maintaining the dynamic balance of protein interactions and its obvious overexpression in MI and HF that implies pathological involvement. Functional experiments are definitely needed for further revealing its potential influences on MI- or HF-led myocardial injury. Conclusion: Our results have implications not only for the coming miRNA-based strategy in treating MI and HF but also for further understanding on gene regulation by miRNAs in human heart.

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CADgene: a comprehensive database for coronary artery disease genes

Cited by 79 publications

References 26 publications

OLR1,PON1andMTHFRGene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population

OLR1,PON1andMTHFRGene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population

On the fractal analysis of gene sequences involved in atherosclerosis by binary image indicator matrix

Functional Network Analysis Reveals Versatile MicroRNAs in Human Heart

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