Cadherins and the formation of neural circuitry in the vertebrate CNS

Redies, Christoph

doi:10.1007/s004410050947

Cited by 72 publications

(67 citation statements)

References 69 publications

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“…Cadherins are cell surface glycoproteins that regulate morphogenesis by mediating Ca 2ϩ -dependent cell-cell adhesion (reviewed in Takeichi, 1995;Gumbiner, 1996). Cadherins were previously shown to be expressed by particular brain nuclei and neural circuits in the developing chicken and mouse CNS (reviewed in Redies, 1995Redies, , 1997Redies and Takeichi, 1996). In the present study, the expression of cadherin-6B and cadherin-7 (Nakagawa and Takeichi, 1995) is mapped in detail.…”

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confidence: 92%

Cadherin expression in the retina and retinofugal pathways of the chicken embryo

et al. 1998

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The expression of two calcium-dependent adhesion molecules of the cadherin superfamily (cadherin-6B and cadherin-7) was mapped in the embryonic neural retina and retinofugal pathways of the chicken embryo and compared with the expression of R-cadherin, N-cadherin, and B-cadherin, studied previously. Whereas B-cadherin is only found in Miller glia, the other four cadherins are each expressed by specific subpopulations of retinal neurons. For example, different (but partly overlapping) populations of bipolar cells express R-cadherin, cadherin-6B, and cadherin-7. Cadherin-6B and cadherin-7 are also expressed by subsets of amacrine cells. In the inner plexiform layer, cadherin-6B and cadherin-7 immunoreactivities are restricted to specific sublaminae associated with synapsin-I-positive nerve terminals. In addition, cadherin-6B and cadherin-7 are expressed by a subset of ganglion cells that project to several retinorecipient nuclei forming part of the accessory optic system (e.g., nucleus of the basal optic root and external pretectal nucleus). Together with their connecting fiber tracts, these nuclei also express cadherin-6B and cadherin-7 in their neurons and neuropile. The expression patterns of the two cadherins overlap but show distinct differences. Some other visual nuclei express cadherin-7 but not cadherin-6B. The expression patterns differ from those previously described for N- and R-cadherin. Together, these results demonstrate that cadherins could provide a system of adhesive cues that specify developing retinal circuits and other functional connections and subsystems in the embryonic chicken visual system.

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confidence: 92%

Cadherin expression in the retina and retinofugal pathways of the chicken embryo

et al. 1998

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“…terns of these cadherins have been examined in various tissues and organs, including the central nervous system (Bitzur et al, 1994;Franklin and Sargent, 1996;Kimura et al, 1996;Redies, 1997;Vallin et al, 1998;Liu et al, 1999;Babb et al, 2001), but there is little information on their distribution and function in the developing vertebrate limb.…”

Section: Introductionmentioning

confidence: 99%

Cadherin‐1, ‐2, and ‐11 expression and cadherin‐2 function in the pectoral limb bud and fin of the developing zebrafish

Liu¹,

Kerstetter²,

Azodi³

et al. 2003

Developmental Dynamics

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Cadherins are cell adhesion molecules that play important roles in development of a variety of organs, including the vertebrate limb. In this study, we analyze cadherin expression patterns in the embryonic zebrafish pectoral limb buds and larval pectoral fins by using both in situ hybridization and immunocytochemical methods. cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins. Cadherin-2 is expressed in the pectoral limb bud mesenchyme and chondrogenic condensation. As development proceeds, cadherin-2 expression is detected in newly differentiated pectoral fin endoskeleton, but its expression is greatly down-regulated in the fin endoskeleton of larval zebrafish. cadherin-11 is found in the basal region of the embryonic limb buds and in the proximal endoskeleton of the larval pectoral fins. Interfering with cadherin-2 function using two specific antisense morpholino oligonucleotides disrupts formation of the chondrogenic condensation/endoskeleton, suggesting that cadherin-2 is crucial for the normal development of the zebrafish pectoral fins. Developmental Dynamics 228:734 -739, 2003.

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“…The functional significance of neural E-cadherin expression is unclear. Cadherin expression patterns implicate these molecules in regionalization processes during nervous system development (Redies, 1997;Redies and Takeichi, 1996;Yagi and Takeichi, 2000). A combinatorial code has been proposed that describes how differential cell-cell adhesion segregates neuron groups into functional circuits (Redies and Takeichi, 1996).…”

Section: Introductionmentioning

confidence: 99%

Zebrafish E‐cadherin: Expression during early embryogenesis and regulation during brain development

Babb

Barnett

Doedens

et al. 2001

Developmental Dynamics

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ABSTRACT:Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain-hindbrain boundary (MHB). Developmental regulation of MHB formation involves wnt1 and pax2.1. wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHB was dependent on normal development of this structure.

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Cadherins and the formation of neural circuitry in the vertebrate CNS

Cited by 72 publications

References 69 publications

Cadherin expression in the retina and retinofugal pathways of the chicken embryo

Cadherin expression in the retina and retinofugal pathways of the chicken embryo

Cadherin‐1, ‐2, and ‐11 expression and cadherin‐2 function in the pectoral limb bud and fin of the developing zebrafish

Zebrafish E‐cadherin: Expression during early embryogenesis and regulation during brain development

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