Cadmium and hypertension in exposed workers: A meta-analysis

Caciari, Tiziana; Sancini, A.; Fioravanti, Mario; Capozzella, Assunta; Casale, Teodorico; Montuori, L; Fiaschetti, M.; Schifano, M. P.; Andreozzi, G; Nardone, N; Tomei, Gianfranco; Ciarrocca, Manuela; Rosati, Maria Valeria; Tomei, Francesco

doi:10.2478/s13382-013-0111-5

Cited by 49 publications

(23 citation statements)

References 40 publications

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“…This result is in line with those of previous studies showing that high levels of blood xenobiotic metals (Cd, Pb, Hg) led to increased risk of cardiovascular diseases such as coronal and peripheral arterial disease [26,27], atherosclerosis [28][29][30], and hypertension [11,31]. Our findings extend this concept to cardiovascular disease of atherosclerosis origin.…”

Section: Discussionsupporting

confidence: 93%

Association between Blood Heavy Metal Levels and Predicted 10-Year Risk for A First Atherosclerosis Cardiovascular Disease in the General Korean Population

Choi

Kwon

et al. 2020

IJERPH

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Background: Atherosclerotic cardiovascular disease (ASCVD) is a preventable type of disease, thus, specifying factors that increase the occurrence of this type of disease is needed. Heavy metals such as cadmium (Cd), lead (Pb), and mercury (Hg) have been suggested as possible factors influencing the development of cardiovascular disease. We aimed to link blood heavy metal levels (Cd, Pb, Hg) with 10-year ASCVD risk scores. Methods: A population of 993 men and 1431 women who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) were included. The 2013 American College of Cardiology/American Heart Association (ACC/AHA) pooled cohort equations risk prediction model and Korean Risk Prediction Model (KRPM) were used as means for risk prediction. Following multivariate adjustment; blood Cd; Pb; and Hg levels were divided into quartiles for analysis using linear trends estimation and multiple regression models. Results: There was an overall positive trend between blood Cd, Pb, and Hg levels and 10-year ASCVD risk scores; KRPM risk score increasing by quartile for blood Cd (men p < 0.0001, women p = 0.0024), Pb (men p = 0.0097, women p = 0.0330), Hg (men p = 0.0096, women p = 0.0030) rates and pooled cohort equations risk score increasing by quartile for Cd (men p < 0.0001, women p = 0.0034) and Hg (men p = 0.0099, women p = 0.0010) with linear trends. Urban population showed a stronger relationship between blood Cd, Pb, and Hg levels and 10-year ASCVD risk score especially among men with multiple regression analysis. Conclusion: Blood Cd, Pb, and Hg levels are associated with ASCVD risk. Thus, they should be considered while developing preventive measures for ASCVD.

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Section: Discussionsupporting

confidence: 93%

Association between Blood Heavy Metal Levels and Predicted 10-Year Risk for A First Atherosclerosis Cardiovascular Disease in the General Korean Population

Choi

Kwon

et al. 2020

IJERPH

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“…Increasing evidence supports that cadmium may play a role in the development of a number of traditional CVD risk factors, including hypertension [16, 63•, 78, 85] and chronic kidney disease [18, 79, 86], which could mediate in part the cardiovascular effects of cadmium. The association with diabetes is inconsistent across studies [86–88].…”

Section: Discussionmentioning

confidence: 99%

Cadmium Exposure and Clinical Cardiovascular Disease: A Systematic Review

Téllez-Plaza

Jones

Dominguez-Lucas

et al. 2013

Curr Atheroscler Rep

231

127

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Mounting evidence supports that cadmium, a toxic metal found in tobacco, air and food, is a cardiovascular risk factor. Our objective was to conduct a systematic review of epidemiologic studies evaluating the association between cadmium exposure and cardiovascular disease. Twelve studies were identified. Overall, the pooled relative risks (95% confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were: 1.36 (95%CI: 1.11, 1.66), 1.30 (95%CI: 1.12, 1.52), 1.18 (95%CI: 0.86, 1.59), and 1.49 (95%CI: 1.15, 1.92), respectively. The pooled relative risks for cardiovascular disease in men, women and never smokers were 1.29 (1.12, 1.48), 1.20 (0.92, 1.56) and 1.27 (0.97, 1.67), respectively. Together with experimental evidence, our review supports the association between cadmium exposure and cardiovascular disease, especially for coronary heart disease. The number of studies with stroke, HF and PAD endpoints was small. More studies, especially studies evaluating incident endpoints, are needed.

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“…However, Cd is also toxic to other tissues including the heart, lungs, and adipose tissues [ 2 ]. Epidemiologic and preclinical studies show that low to moderate Cd exposure is associated with cardiovascular (CV) dysfunction and disease including arrhythmias [ 3 , 4 ], hypertension [ 5 , 6 ], myocardial infarction [ 7 , 8 ], and heart failure [ 9 – 11 ]. Urine Cd levels are associated with increased CV disease incidence and mortality [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms

Zhen

et al. 2019

Acta Pharmacol Sin

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Cadmium (Cd) is a nonessential heavy metal and a prevalent environmental toxin that has been shown to induce significant cardiomyocyte apoptosis in neonatal murine engineered cardiac tissues (ECTs). In contrast, zinc (Zn) is a potent metallothionein (MT) inducer, which plays an important role in protection against Cd toxicity. In this study, we investigated the protective effects of Zn against Cd toxicity in ECTs and explore the underlying mechanisms. ECTs were constructed from neonatal ventricular cells of wild-type (WT) mice and mice with global MT gene deletion (MT-KO). In WT-ECTs, Cd (5−20 μM) caused a dose-dependent toxicity that was detected within 8 h evidenced by suppressed beating, apoptosis, and LDH release; Zn (50−200 μM) dose-dependently induced MT expression in ECTs without causing ECT toxicity; co-treatment of ECT with Zn (50 µM) prevented Cd-induced toxicity. In MT-KO ECTs, Cd toxicity was enhanced; but unexpectedly, cotreatment with Zn provided partial protection against Cd toxicity. Furthermore, Cd, but not Zn, significantly activated Nrf2 and its downstream targets, including HO-1; inhibition of HO-1 by a specific HO-1 inhibitor, ZnPP (10 µM), significantly increased Cd-induced toxicity, but did not inhibit Zn protection against Cd injury, suggesting that Nrf2-mediated HO-1 activation was not required for Zn protective effect. Finally, the ability of Zn to reduce Cd uptake provided an additional MT-independent mechanism for reducing Cd toxicity. Thus, Zn exerts protective effects against Cd toxicity for murine ECTs that are partially MT-mediated. Further studies are required to translate these findings towards clinical trials.

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Cadmium and hypertension in exposed workers: A meta-analysis

Cited by 49 publications

References 40 publications

Association between Blood Heavy Metal Levels and Predicted 10-Year Risk for A First Atherosclerosis Cardiovascular Disease in the General Korean Population

Association between Blood Heavy Metal Levels and Predicted 10-Year Risk for A First Atherosclerosis Cardiovascular Disease in the General Korean Population

Cadmium Exposure and Clinical Cardiovascular Disease: A Systematic Review

Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms

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