Cadmium and mercury cause an oxidative stress-induced endothelial dysfunction

Wolf, Matthew B.; Baynes, John W.

doi:10.1007/s10534-006-9016-0

Cited by 92 publications

(61 citation statements)

References 26 publications

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“…In line with that, Elia et al (2003) also found that moderate doses of mercury were able to increase GST and GPx activities in Ictalurus melas, whereas high concentrations inhibited those enzymes. Similarly, Wolf and Baynes (2007) have described that in mammals high concentrations of mercury ([3-5 lM) induced GSH depletion and inhibition of thiol enzymes activity, whereas low concentrations (1-2 lM) increased those parameters.…”

Section: Oxidative Stress Responses and Association With Mercury Accumentioning

confidence: 82%

Antioxidant system breakdown in brain of feral golden grey mullet (Liza aurata) as an effect of mercury exposure

et al. 2010

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Although brain has been recognized as a primary target for mercury toxicity in mammals, the effects of this metal in fish brain are scarcely described. Thus, the main objective of this study was to assess the mercury threat to feral fish (Liza aurata) by estimating the antioxidant defenses and peroxidative damage in brain, keeping in mind the association with mercury accumulation. Sampling was carried out in an estuarine area historically affected by discharges from a chlor-alkali industry-Laranjo Basin (Ria de Aveiro, Portugal). Total mercury (T-Hg) in brain increased towards the contamination source, clearly indicating mercury exposure. An overall antioxidant depletion was verified in brain of fish collected at the mercury-contaminated stations, since total glutathione content and the studied antioxidant enzymes (catalase-CAT, glutathione peroxidase-GPx, glutathione-S-transferase-GST and glutathione reductase-GR) significantly decreased. In addition, this breakdown of the redox-defense system was significantly correlated with the accumulated T-Hg levels. Unexpectedly, fish exhibited unaltered lipid peroxidation levels, pointing out a higher propensity of mercury to inhibit enzymes than to oxidatively damage lipids in the brain. Nevertheless, an increased susceptibility of the fish's brain was identified, leaving the organ more vulnerable to oxidative stress-related challenges. Overall, the current findings provide information to better understand mechanisms of mercury neurotoxicity in fish.

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Section: Oxidative Stress Responses and Association With Mercury Accumentioning

confidence: 82%

Antioxidant system breakdown in brain of feral golden grey mullet (Liza aurata) as an effect of mercury exposure

et al. 2010

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“…Kim and Sharma (2004) found, that initial action of mercury on macrophages is going through the mobilization of Ca 2+ ions and resulting in increased reactive oxygen species (ROS) production leading to apoptotic and necrotic changes in macrophages. Mercury increased free radical production and oxidative stress in animal and human studies (Wiggers et al, 2008;Wolf & Baynes, 2007). On the contrary, low doses of Hg (2 -4 µM) stimulated NO production in cells of rats (Ellis et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Effect of heavy metal intoxication on macrophage metabolic activity of mice infected with Ascaris suum

Jalčová

2014

Helminthologia

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SummaryThe effect of heavy metal intoxication on superoxide anion (O 2 -) production and larval burden during experimental Ascaris suum infection was studied. Mice were chronically intoxicated with lead (Pb), cadmium (Cd) or mercury (Hg) and subsequently infected with A. suum. The metabolic activity of peritoneal macrophages in mice intoxicated with Pb was suppressed and subsequent parasitic infection did not change this inhibition. Cd intoxication increased the superoxide production and also stimulated the activity of this oxygen radical after A. suum infection. Intoxication with Hg had a stimulative effect on the macrophage metabolic activity and subsequent A. suum infection moderately reduced this activity. Parasite burden was different depending on a type of heavy metal intoxication. Pb intoxication moderately increased the parasite burden in the liver and lungs of intoxicated mice. In contrast, Cd and Hg intoxication triggered a marked reduction of A. suum larvae in the liver and lungs of intoxicated mice, respectively. Monitored heavy metals differed in their immunomodulatory effect on metabolic activity of macrophages what also altered the intensity of the parasite infection in the hosts.

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“…Despite lack of correlation between BCd and fibrin D-dimer level, it cannot be excluded that fibrinolysis-induced endothelial damage may be disturbed by cadmium. It is suggested that the mechanism of fibrinolytic system activation by cadmium may result from multidirectional effect of this metal, including interactions with essential elements, disturbances of red-ox processes or increased endothelium permeability [46,47]. In plasma of the women with endometrial cancer, an increase of t-PA level was detected, which did not occur in the women with myoma.…”

Section: Discussionmentioning

confidence: 99%

The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

Nasiadek¹,

Kilanowicz²,

Daragó³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Objectives: Cadmium (Cd) is a persistent and widespread environmental pollutant, which may constitute a potential risk factor for hormone-dependent tumors such as endometrial cancer. The vascular endothelium is an important target of cadmium toxicity, which may interfere with the coagulation cascade and fibrinolytic system. The aim of this research was to investigate whether in female patients with uterine endometrial cancer or myoma in comparison to healthy women, the concentration of cadmium in blood affects the process of coagulation and fibrinolysis. Materials and Methods: The study group comprised 91 women: 35 healthy (A-control), 39 with uterine myoma (B) and 17 with endometrial cancer (C), in which blood cadmium concentrations (BCd), coagulation and selected fibrinolysis parameters in plasma were assayed. Results: In the women with myoma and especially in those with endometrial cancer disturbances in coagulation and fibrinolysis were detected when compared to the healthy women. In the group of women with endometrial cancer significant changes in prothrombin index, levels of fibrinogen, fibrin D-dimer and t-PA were observed. Whereas, in the patients with myoma significant changes in prothrombin time, index of vWillebrand Factor and fibrin D-dimer level were noted. Mean BCd concentrations in subsequent groups were as follows: B -0.91±0.81; C -0.78±0.45 μg Cd/l and did not differ significantly in comparison with the control group (0.86±0.35 μg Cd/l). However, in each study group smokers had approximately twice as high BCd as non-smokers. Studies also showed significant associations between BCd and fibrinogen level and thrombin time among the women with myoma and endometrial cancer, as well as in healthy women. Moreover, thrombin time significantly correlated with fibrinogen level in the women studied. Conclusions: In the patients with myoma and especially in these with endometrial cancer disturbances in coagulation and fibrinolysis parameters leading to hypercoagulability were detected. Exposure to cadmium can be one of the factors inducing these changes.

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Cadmium and mercury cause an oxidative stress-induced endothelial dysfunction

Cited by 92 publications

References 26 publications

Antioxidant system breakdown in brain of feral golden grey mullet (Liza aurata) as an effect of mercury exposure

Antioxidant system breakdown in brain of feral golden grey mullet (Liza aurata) as an effect of mercury exposure

Effect of heavy metal intoxication on macrophage metabolic activity of mice infected with Ascaris suum

The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

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