Cadmium chloride exhibits a profound toxic effect on bacterial microflora of the mice gastrointestinal tract

Fazeli, Mehdi; Hassanzadeh, Parichehr; Alaei, S.

doi:10.1177/0960327110369821

Cited by 80 publications

(53 citation statements)

References 45 publications

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“…A discriminant analysis of band classes (performed with Bionumerics software) enabled us to distinguish between fecal and colonic samples (Figure 2) and between control samples and HM-treated samples but did not pinpoint systematic differences between Pb and Cd treatments or between low and high concentrations of the HMs (results not shown). This finding contrasts with a recent report in which oral Cd had harmful effects on the viability of some components of the mouse microbiota [18]. This disparity might be explained by the fact that Fazeli and coworkers used restrictive conventional culture methods, whereas we used a molecular approach.…”

Section: Resultscontrasting

confidence: 90%

Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome

Breton

Massart

Vandamme

et al. 2013

BMC Pharmacol Toxicol

194

114

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BackgroundThe gut microbiota is critical for intestinal homeostasis. Recent studies have revealed the links between different types of dysbiosis and diseases inside and outside the intestine. Environmental exposure to pollutants (such as heavy metals) can also impair various physiological functions for good health. Here, we studied the impact of up to 8 weeks of oral lead and cadmium ingestion on the composition of the murine intestinal microbiome.ResultsPyrosequencing of 16S RNA sequences revealed minor but specific changes in bacterial commensal communities (at both family and genus levels) following oral exposure to the heavy metals, with notably low numbers of Lachnospiraceae and high numbers levels of Lactobacillaceae and Erysipelotrichaceacae (mainly due to changes in Turicibacter spp), relative to control animals.ConclusionsNon-absorbed heavy metals have a direct impact on the gut microbiota. In turn, this may impact the alimentary tract and overall gut homeostasis. Our results may enable more accurate assessment of the risk of intestinal disease associated with heavy metal ingestion.

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Section: Resultscontrasting

confidence: 90%

Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome

Breton

Massart

Vandamme

et al. 2013

BMC Pharmacol Toxicol

194

114

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“…93 Breton et al also reported minor but specific changes in the composition of the colonic microbiota at the family and genus levels, following chronic treatment with cadmium and lead in mice. Heavy metal-consuming animals had smaller numbers of Lachnospiraceae and larger numbers of Lactobacillaceae and Erysipelotrichaceacae than control animals.…”

Section: Environmental Chemicals Can Affect the Composition And/or Thmentioning

confidence: 96%

The gut microbiota: a major player in the toxicity of environmental pollutants?

Claus

Guillou

Ellero‐Simatos

2016

npj Biofilms Microbiomes

531

328

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Exposure to environmental chemicals has been linked to various health disorders, including obesity, type 2 diabetes, cancer and dysregulation of the immune and reproductive systems, whereas the gastrointestinal microbiota critically contributes to a variety of host metabolic and immune functions. We aimed to evaluate the bidirectional relationship between gut bacteria and environmental pollutants and to assess the toxicological relevance of the bacteria–xenobiotic interplay for the host. We examined studies using isolated bacteria, faecal or caecal suspensions—germ-free or antibiotic-treated animals—as well as animals reassociated with a microbiota exposed to environmental chemicals. The literature indicates that gut microbes have an extensive capacity to metabolise environmental chemicals that can be classified in five core enzymatic families (azoreductases, nitroreductases, β-glucuronidases, sulfatases and β-lyases) unequivocally involved in the metabolism of >30 environmental contaminants. There is clear evidence that bacteria-dependent metabolism of pollutants modulates the toxicity for the host. Conversely, environmental contaminants from various chemical families have been shown to alter the composition and/or the metabolic activity of the gastrointestinal bacteria, which may be an important factor contributing to shape an individual’s microbiotype. The physiological consequences of these alterations have not been studied in details but pollutant-induced alterations of the gut bacteria are likely to contribute to their toxicity. In conclusion, there is a body of evidence suggesting that gut microbiota are a major, yet underestimated element that must be considered to fully evaluate the toxicity of environmental contaminants.

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“…This study identified an association of Cd treatment with a decrease in mucus thickness, which supports a mechanism of increased gut permeability. Furthermore, various concentrations of heavy metals have demonstrated to be growth limiting or retarding against diverse microorganisms [20], [21]. The toxic effects of heavy metals on gut microbiota impose great impact on food digestion as well as host health [12], [13].…”

Section: Discussionmentioning

confidence: 99%

Exposing to Cadmium Stress Cause Profound Toxic Effect on Microbiota of the Mice Intestinal Tract

Liu

et al. 2014

PLoS ONE

101

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Cadmium (Cd), one of the heavy metals, is an important environmental pollutant and a potent toxicant to organism. It poses a severe threat to the growth of the organism, and also has been recognized as a human carcinogen. However, the toxicity of cadmium and its influences on microbiota in mammal's intestine are still unclear. In our experiment, the changes of intestinal microbiota in two groups of mice were investigated, which were supplied with 20 and 100 mg kg−1 cadmium chloride respectively for 3 weeks. The control group was treated with water free from cadmium chloride only. This study demonstrated that Cd accumulated in some tissues of mice after Cd administration and the gut barrier was impaired. Cd exposure also significantly elevated the colonic level of TNF-α. On the other hand, Cd-treatment could slow down the growth of gut microbiota and reduced the abundance of total intestinal bacteria of the mice. Among them, the growth of Bacteroidetes was significantly suppressed while Firmicutes growth was not. The probiotics including Lactobacillus and Bifidobacterium were notably inhibited. We also observed that the copies of key genes involved in the metabolism of carbohydrates to short-chain fatty acids (SCFAs) were lower in Cd-treated groups than control. As a result, the levels of short-chain fatty acids in colonic decreased significantly. In summary, this study provides valuable insight into the effects of Cd intake on mice gut microbiota.

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Cadmium chloride exhibits a profound toxic effect on bacterial microflora of the mice gastrointestinal tract

Cited by 80 publications

References 45 publications

Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome

Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome

The gut microbiota: a major player in the toxicity of environmental pollutants?

Exposing to Cadmium Stress Cause Profound Toxic Effect on Microbiota of the Mice Intestinal Tract

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