Cadmium, Chromium, and Copper Induce Polychromatocyte Micronuclei in Carp ( Cyprinus carpio L.)

Zhu, Yi; Wang, Jianyun; Bai, Yingchen; Zhang, R.

doi:10.1007/s00128-003-0243-6

Cited by 47 publications

(24 citation statements)

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“…This study revealed that although both effluents had genotoxic potential on the fish, the frequencies of lobed nuclei (LN), blebbed nuclei (BL), and notched nuclei (NT) were not significant (Cavas and Ergene-Gozukara, 2005). Similar results were also reported in C. carpio (Zhu et al, 2004). On the other hand, Pimephales promelas exposed to different concentrations ofchromium viz., 1.0, 1.5, 2.0, 2.5 mg L−1 for different exposure times (7, 14, 21days) demonstrated significant induction of micronuclei (MN) at the 2.5 mg L−1 concentration after 7 days exposure (De-Lemos et al, 2001).…”

Section: Genotoxicity Due To Heavy Metalssupporting

confidence: 86%

Scenario of Genotoxicity in Fishes and Its Impact on Fish Industry

Mir¹,

Khan²,

Bhat³

et al. 2014

IOSRJESTFT

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Section: Genotoxicity Due To Heavy Metalssupporting

confidence: 86%

Scenario of Genotoxicity in Fishes and Its Impact on Fish Industry

Mir¹,

Khan²,

Bhat³

et al. 2014

IOSRJESTFT

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“…Oreochromis niloticus, Poronotus triacanthus and Puntius altus at 25% of 96-hr LC50 of lead, copper and cadmium and reported significant increase in micronuclei frequency and frequency of other nuclear abnormalities (notched, blebbed, lobed and binucleated cells) in fish erythrocytes after 48-hr exposure. Induction of micronuclei and other nuclear abnormalities in the erythrocytes of C. carpio due to copper exposure was also reported by Zhu et al (2004). Guner et al (2011) reported significantly increased frequency of nuclear abnormalities in the erythrocytes of G. affinis due to copper and cadmium toxicity.…”

Section: Discussionsupporting

confidence: 58%

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Kousar¹,

Javed²

2015

Turk. J. Fish. Aquat. Sci.

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A wide variety of chemicals especially metals contaminate the aquatic ecosystem and stimulate a variety of toxicity mechanisms, such as oxidative damage to proteins, DNA and lipids. Very limited efforts have been made to investigate the genotoxic effects of metals in fish. Therefore, the present study was conducted to determine copper induced genotoxic damage in peripheral blood erythrocytes of 150-day old four freshwater fish species viz. Labeo rohita, Cirrhina mrigala, Catla catla and Ctenopharyngodon idella by using micronucleus test. For this purpose, 96-hr LC50 and lethal concentration of copper for all the four fish species were determined. Each fish species was exposed to four different sub-lethal concentrations (17, 25, 33, 50% of 96-hr LC50) of copper, separately, for a period of 30 days. Results showed exposure concentration dependent increases in the frequencies of micronuclei and other nuclear abnormalities. Findings of the experiment also confirmed that the micronucleus test acts as a useful tool in determining the potential genotoxicity of metals in erythrocytes of various fish species. Among four fish species, Cirrhina mrigala showed significantly higher frequency of micronuclei with the mean value of 16.98±11.70%, followed by that of Ctenopharyngodon idella, Catla catla and Labeo rohita. However, frequency of other nuclear abnormalities followed the order: Labeo rohita > Cirrhina mrigala > Ctenopharyngodon idella > Catla catla.

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“…Induction of micronuclei was reported previously for fish exposed to Cd [Ayllon and Garcia Vazquez, 2000;Sanchez-Galan et al, 2001;Zhu et al, 2004;Arkhipchuk and Garanko, 2005;Cavas et al, 2005], Cu [Zhu et al, 2004;Arkhipchuk and Garanko, 2005;Cavas et al, 2005], Cr [Al-Sabti et al, 1994;de Lemos et al, 2001;Zhu et al, 2004], and Pb Ferraro et al, 2004]. Therefore, it is plausible that elevated concentrations of heavy metals could have contributed to the elevated MN and NA frequencies produced by the downstream Berdan River water samples.…”

Section: Discussionmentioning

confidence: 57%

Evaluation of river water genotoxicity using the piscine micronucleus test

Ergene

Çavaş

Çelık

et al. 2007

Environ and Mol Mutagen

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The Berdan River, which empties into the Mediterranean Sea on the east coast of Turkey, receives discharges of industrial and municipal waste. In the present study, the in vivo piscine micronucleus (MN) test was used to evaluate the genotoxicity of water samples collected from different locations along the Berdan River. Nile tilapia (Oreochromis niloticus) were exposed in the laboratory for 2, 4, and 6 days, and micronuclei were evaluated in peripheral blood erythrocytes, gill cells, and caudal fin epithelial cells. A single dose of 5 mg/L cyclophosphamide was used as a positive control. In addition to micronuclei, nuclear abnormalities (NAs), such as binucleated cells and blebbed, notched, and lobed nuclei, were assessed in the erythrocytes, and chemical analyses were carried out to determine the amount of heavy metals in the water samples. MN and NA frequencies were significantly elevated (up to 2- to 3-fold) in fish exposed to river water samples taken downstream of potential discharges, and the elevated responses in gill and fin cells were related to the concentration of heavy metals in the water. MN frequencies (expressed as micronucleated cells/1,000 cells), in both treated and untreated fish, were greatest in gill cells (range: 0.80-3.70), and generally lower in erythrocytes (range: 0.50-2.80), and fin cells (range: 0.45-1.70). The results of this study indicate that the Berdan River is contaminated with genotoxic pollutants and that the genotoxicity is related to the discharge of wastes into the river water.

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Cadmium, Chromium, and Copper Induce Polychromatocyte Micronuclei in Carp ( Cyprinus carpio L.)

Cited by 47 publications

References 0 publications

Scenario of Genotoxicity in Fishes and Its Impact on Fish Industry

Scenario of Genotoxicity in Fishes and Its Impact on Fish Industry

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Evaluation of river water genotoxicity using the piscine micronucleus test

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