Cadmium nanoclusters in a protein matrix: Synthesis, characterization, and application in targeted drug delivery and cellular imaging

Sarparast, Morteza; Noori, Abolhassan; Ilkhani, Hoda; Bathaie, S. Zahra; El‐Kady, Maher F.; Wang, Lisa J.; Pham, Hường; Marsh, Kristofer L.; Kaner, Richard B.; Mousavi, Mir F.

doi:10.1007/s12274-016-1201-z

Cited by 40 publications

(38 citation statements)

References 85 publications

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“…Cadmium ions could also be prepared into luminescent nanoclusters with albumin as the template 64 . The prepared nanoclusters could be modified with a tumor-targeted ligand, such as hyaluronic acid (HA), for cancer cell-specific drug delivery.…”

Section: Albumin As a Template For Nanoparticle Preparation And Its Bmentioning

confidence: 99%

Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

2017

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Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient of human blood without immunogenicity and encouraged by its successful clinical application in Abraxane, albumin has been regarded as a promising material to produce nanoparticles for bioimaging and drug delivery. The strategies for synthesizing albumin-based nanoparticles could be generally categorized into five classes: template, nanocarrier, scaffold, stabilizer and albumin-polymer conjugate. This review introduces approaches utilizing albumin in the preparation of nanoparticles and thereby provides scientists with knowledge of goal-driven design on albumin-based nanomedicine.

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Section: Albumin As a Template For Nanoparticle Preparation And Its Bmentioning

confidence: 99%

Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

2017

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“…24 Due to the superiority of super-specific targeting of tumor cells and immune cells, cellular imaging capability and low cytotoxicity, the nanocarrier-based therapeutic delivery system is widely used for various diseases. 25,26 Actually, the nanocarrier is more preferable than traditional formulation in improving the efficacy of topical therapeutic, minimizing the side-effects of prolonged use and reducing dose of administration. 27,28 Liposome is one of the most reported nanocarriers, which is a naturally occurring phospholipid-based amphipathic nanocarrier.…”

Section: Discussionmentioning

confidence: 99%

Topical administration of nanocarrier miRNA‐210 antisense ameliorates imiquimod‐induced psoriasis‐like dermatitis in mice

Feng

Zhang

et al. 2019

The Journal of Dermatology

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Psoriasis is a chronic, recurrent inflammatory autoimmune skin disease. Although its etiology and pathogenesis are complex and multifarious, it has been proved to be closely related to dysregulation of immune cell function as well as keratinocyte proliferation/differentiation. Our previous study demonstrated that miRNA-210 (miR-210) plays an important role in the formation of skin lesions and immune imbalance in psoriasis. Here, we developed a biomimetic reconstituted high-density lipoprotein (rHDL) nanocarrier gel containing miR-210 antisense (NG-anti-miR-210) to investigate its effect on imiquimod (IMQ)-induced psoriasis-like dermatitis in mice. We found that topical treatment with NG-anti-miR-210 significantly decreased the expression of miR-210 in both the skin lesions and splenic CD4 + T cells from IMQ-induced psoriasis-like mouse models and ameliorated the dermatitis in terms of the erythema, scales, acanthosis and dermal inflammatory cell infiltration in IMQ-induced mice. In addition, the proportion of T-helper (Th)1 and Th17 cells in dermal and splenic cells of IMQ-treated mice were decreased by application of NG-anti-miR-210, accompanied by decreased interleukin-17A and c-interferon mRNA levels. Therefore, our data demonstrate that topical inhibition of miR-210 delivered by rHDL nanocarrier effectively alleviates the psoriasis-like inflammation in mice and provides a potentially effective topical drug for psoriasis.

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“…However, this work applied electrochemical investigations not fluorescent studies, and hence, cannot be attested to our current focus. The uses of metal nanoclusters of Cd and Ir were also validated in cellular imaging studies [170,171]. Sarparast et al represented such Cd NCs in a protein matrix, which were applied in targeted drug delivery and cellular imaging [170].…”

Section: Other Metal Nanoclusters As Sensorsmentioning

confidence: 99%

“…The uses of metal nanoclusters of Cd and Ir were also validated in cellular imaging studies [170,171]. Sarparast et al represented such Cd NCs in a protein matrix, which were applied in targeted drug delivery and cellular imaging [170]. In a similar fashion, Vankayala and co-workers recognized the cellular imaging practice of highly fluorescent and biocompatible Ir NCs with a quantum yield of 0.36% [171].…”

Section: Other Metal Nanoclusters As Sensorsmentioning

confidence: 99%

Luminescent Metal Nanoclusters for Potential Chemosensor Applications

Shellaiah

Sun

2017

Chemosensors

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Studies of metal nanocluster (M-NCs)-based sensors for specific analyte detection have achieved significant progress in recent decades. Ultra-small-size (<2 nm) M-NCs consist of several to a few hundred metal atoms and exhibit extraordinary physical and chemical properties. Similar to organic molecules, M-NCs display absorption and emission properties via electronic transitions between energy levels upon interaction with light. As such, researchers tend to apply M-NCs in diverse fields, such as in chemosensors, biological imaging, catalysis, and environmental and electronic devices. Chemo-and bio-sensory uses have been extensively explored with luminescent NCs of Au, Ag, Cu, and Pt as potential sensory materials. Luminescent bi-metallic NCs, such as Au-Ag, Au-Cu, Au-Pd, and Au-Pt have also been used as probes in chemosensory investigations. Both metallic and bi-metallic NCs have been utilized to detect various analytes, such as metal ions, anions, biomolecules, proteins, acidity or alkalinity of a solution (pH), and nucleic acids, at diverse detection ranges and limits. In this review, we have summarized the chemosensory applications of luminescent M-NCs and bi-metallic NCs.

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Cadmium nanoclusters in a protein matrix: Synthesis, characterization, and application in targeted drug delivery and cellular imaging

Cited by 40 publications

References 85 publications

Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

Topical administration of nanocarrier miRNA‐210 antisense ameliorates imiquimod‐induced psoriasis‐like dermatitis in mice

Luminescent Metal Nanoclusters for Potential Chemosensor Applications

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