Cadmium sanguin et zinc plasmatique chez l'hypertendu

Imbalance of zinc and copper status has been hypothesized in human hypertension. A case-control study was carried out to elucidate the possible relationship between zinc and copper status and essential hypertension. Thirty-one subjects affected by mild stable hypertension, pharmacologically untreated, were investigated together with 31 normotensive controls individually matched for sex, age, and smoking habits. Zinc and copper in serum and urine wee measured, and serum activities of alkaline phosphatase (AP), lactic dehydrogenase (LDH), copper-zinc superoxide dismutase (Cu-Zn SOD), lysyl oxidase (LOX), and monoamine oxidase (MAO) were evaluated. No significant difference in serum and urine zinc and copper content as far as in serum activity of zinc (AP and LDH) or copper (Cu-Zn SOD, LOX, and MAO)-dependent enzymes was found between hypertensives and normotensives. Positive relationships were found in normotensives between serum and urine levels of zinc (r = 0.577; p = 0.001) and copper (r = 0.394; p = 0.028), and between serum copper and Cu-Zn SOD (r = 0.534; p = 0.002). In normotensives, diastolic blood pressure and serum zinc were positively related (r = 0.370; p = 0.041). In hypertensives, inverse correlations were observed between diastolic blood pressure and AP (r = -0.498; p = 0.004) and Cu-Zn SOD (r = 0.452; p = 0.011), and between systolic blood pressure and LOX (r = -0.385; p = 0.033). Diastolic blood pressure was related to LDH inversely in hypertensives (r = -0.357; p = 0.049) and positively in normotensives (r = 0.457; p = 0.010). In normotensives, diastolic blood pressure was inversely related with MAO (r = -0.360; p = 0.046). These findings support the hypothesis that an imbalance of zinc and copper status might be involved in human hypertension.

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Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension

Vivoli

Bergomi

Rovesti

et al. 1995

Biol Trace Elem Res

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Concentrations of cadmium, lead, selenium, and zinc in human blood and seminal plasma

Xu¹,

Chia²,

Ong³

1994

Biol Trace Elem Res

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The concentrations of cadmium, lead, selenium, and zinc in blood and seminal plasma were determined in 76 Singapore males. Except for zinc, the concentrations were generally higher in blood than in seminal plasma (cadmium, 1.31 micrograms/L vs 0.61 micrograms/L; lead, 82.6 micrograms/L vs 12.4 micrograms/L, and selenium, 163.6 micrograms/L vs 71.5 micrograms/L). The mean concentration of zinc in seminal plasma was more than 30 times higher than in blood (202 mg/L vs 6.2 mg/L). Significant positive correlations were found between the concentrations in blood and seminal plasma for the two essential trace elements: selenium (r = 0.45, p < 0.001) and zinc (r = 0.25, p < 0.05). However, no relationships were found between the concentrations in blood and seminal plasma for two toxic metals (cadmium and lead). Significant inverse correlations were observed between Cd and Zn (r = -0.40, p < 0.01), and Pb and Se (r = -0.32, p < 0.05) in blood, whereas significant positive correlations were noted between Cd and Se (r = 0.45, p < 0.01), Cd and Zn (r = 0.35, p < 0.05), and Se and Zn (r = 0.57, p < 0.001) in seminal plasma. The physiological significance of these relationships are also discussed in this paper.

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Validation of INAA and AAS analysis protocols for whole blood: A study on cardiovascular and malignant hypertensive patients

Rahman

Waheed

2009

J Radioanal Nucl Chem

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Cadmium sanguin et zinc plasmatique chez l'hypertendu

Cited by 5 publications

References 20 publications

Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension

Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension

Concentrations of cadmium, lead, selenium, and zinc in human blood and seminal plasma

Validation of INAA and AAS analysis protocols for whole blood: A study on cardiovascular and malignant hypertensive patients

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