Cadmium stimulates prostaglandin E2 production and bone resorption in cultured fetal mouse calvaria

Suzuki, Yoshiharu; Morita, Ikuo; Yamane, Yasuhiro; Murota, Sei‐itsu

doi:10.1016/s0006-291x(89)80078-6

Cited by 36 publications

(13 citation statements)

References 11 publications

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“…Cadmium is highly toxic, accumulating in the body and eventually causing effects such as tabular dysfunction, disturbances, in calcium homeostatis and metabolism [38]. It is capable of inducing renal, hepatic and testicular injury [39]. Most chromium (VI) compounds are carcinogenic, long exposure may cause kidney, liver and nerve tissue damage [40].…”

Section: Discussionmentioning

confidence: 99%

Effect of Effluents From Warri Refinery Petrochemical Company WRPC on Water and Soil Qualities of “Contiguous Host” and “Impacted on Communities” of Delta State, Nigeria

Nduka¹,

Orisakwe²

2009

TOEPTJ

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This study investigated the effect of refinery effluents on different sources of potable water supply in two areas of Niger Delta contiguous host and impacted on communities of Delta State, Nigeria (surface water, shallow well water and borehole water) in Ekpan, its adjoining communities and creeks. Since open and underground water bodies are regarded as final recipient of most environmental pollutant, we sought through the study to provide data on pollutant load of potable water supply of the study area. Cadmium, chromium, lead and manganese were determined using Atomic Absorption spectrophotometry; physico-chemical parameters such as nitrate,nitrite, pH, Biological oxygen demand BOD, Total hardness TH, salinity and electrical conductivity EC were all determined using their standard methods. Surface water of Aja-Etan and Ijala had highest levels of cadmium (1.45±0.01 and 1.20 ± 0.0(mg/l), that of ifie-kporo and Ekpan had highest lead (1.00 ± 0.01mg/l). Ekpan borehole water is more acidic (4.79± 0.01) than others. Agigba and Ajamimogha surface water had highest level of manganese (2.40 ± 0.03 and 2.20 ± 0.03mg/l). With the exception of Ekpan shallow well, BOD and hardness were in highest concentration in surface water. Some of the parameter were above WHO standards and USEPA maximum contaminant level MCL.

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Section: Discussionmentioning

confidence: 99%

Effect of Effluents From Warri Refinery Petrochemical Company WRPC on Water and Soil Qualities of “Contiguous Host” and “Impacted on Communities” of Delta State, Nigeria

Nduka¹,

Orisakwe²

2009

TOEPTJ

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“…Cadmium can accumulate in the liver and kidney via drinking and eating. It causes injury to the liver, kidney and testis (Suzuki et al 1989). Liver necrosis and cytotoxicity can induced after exposure to large dose of cadmium in rats and mice (Dudley et al 1982, Theocharis et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Cadmium induced hepatic intoxication and amelioration by grape seed extract

Alkhedaide

Youssef²,

Elzoghby

et al. 2017

IJPT

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Cadmium (Cd) is wide-spread toxic metal that pollutes most of the vegetables, which eaten by numerous populations all over the world. The aim of the current work is to evaluate the protective and prophylactic effects of the antioxidant materials in the grape seed extract (GSE) on the hepatic intoxication induced by cadmium chloride toxic material in male Wistar rats. Male adult Wistar rats were divided into four groups. Control group fed on balanced diet and given drinking water. Group two (control positive) given CdCl2 in the dose of 0.44 mg/kg body weight (BW) by stomach tube daily. Group three given grape seed extract GSE in the dose of (100 mg/kg BW) daily by stomach tube. Finally, the fourth group gave mixture of (GSE and CdCl2) by stomach tube in the recommended dose. Blood and liver tissues were collected for further biochemical and histopathological studies. CdCl2 significantly increased the serum levels of malondialdehyde, ALT and AST. Cadmium administration decreased levels of antioxidants (Catalase, GSH-R and GSH-Px). The liver of the control positive groups which given CdCl2 showed degenerative changes in the form of vacuolar and hydropic degeneration. Congestion was evident in the central vein and proliferation of the kupffer cells. These hepatic biochemical and degenerative changes were ameliorated by the co addition of GSE.

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“…It has been indicated that Cd exposure could affect metabolic biomarker of bone resorption (Åkesson et al, 2006;Sughis et al, 2011). In addition, several organ culture systems also indicate that Cd stimulates bone resorption (Suzuki et al, 1989(Suzuki et al, , 1990Miyahara et al, 1992Miyahara et al, , 2001Wang et al, 1994). Microarray analysis shows that bone demineralization stimulated by Cd is related with osteoclast activation (Regunathan et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Environmental level of cadmium exposure stimulates osteoclasts formation in male rats

Chen

Wang

Xu-fang

et al. 2013

Food and Chemical Toxicology

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Cadmium stimulates prostaglandin E2 production and bone resorption in cultured fetal mouse calvaria

Cited by 36 publications

References 11 publications

Effect of Effluents From Warri Refinery Petrochemical Company WRPC on Water and Soil Qualities of “Contiguous Host” and “Impacted on Communities” of Delta State, Nigeria

Effect of Effluents From Warri Refinery Petrochemical Company WRPC on Water and Soil Qualities of “Contiguous Host” and “Impacted on Communities” of Delta State, Nigeria

Cadmium induced hepatic intoxication and amelioration by grape seed extract

Environmental level of cadmium exposure stimulates osteoclasts formation in male rats

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