Cadmium: Toxic effects on the reproductive system and the embryo

Thompson, Jennifer; Bannigan, John

doi:10.1016/j.reprotox.2008.02.001

Cited by 546 publications

(367 citation statements)

References 174 publications

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“…In addition, direct oxidation of membrane lipids, and depletion of anti-oxidants due to a strong affinity for the thiols plentiful in glutathione [40], may account for the inhibitory effect of Pb; a narrow range of reactive oxygen species is critical to proper oocyte development and fertilization [41]. Cadmium too elicits increases in reactive oxygen species [40], as well as alteration of cytosolic Ca 2+ levels, yet most animal studies report reduced oocyte fertilization [42]. It is possible that the association we observe for FF Cd is confounded by associations with one or more essential elements associated with oocyte fertilization, such as FF Zn [43].…”

Section: Associations Between Metals and Oocyte Fertilizationmentioning

confidence: 99%

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Bloom

Kim

Kruger

et al. 2012

J Assist Reprod Genet

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Purpose We previously reported associations between trace concentrations of Hg, Cd and Pb in blood and urine and reproductive outcomes for women undergoing in-vitro fertilization (IVF). Here we assess measurements in single follicular fluid (FF) specimens from 46 women as a presumably more relevant marker of dose for reproductive toxicity. Methods FF specimens were analyzed for Hg, Cd and Pb using sector field-inductively coupled plasma-mass spectrometry (SF-ICP-MS). Variability sources were assessed by nested ANOVA. Multivariable regression was used to evaluate associations for square root transformed metals with IVF outcomes, adjusting for confounders.

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Section: Associations Between Metals and Oocyte Fertilizationmentioning

confidence: 99%

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Bloom

Kim

Kruger

et al. 2012

J Assist Reprod Genet

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“…Cadmium is an occupational and environmental pollutant that has been associated with renal, skeletal, vascular, reproductive and respiratory disorders [21] . Cd-induced oxidative stress has been associated with production of reactive oxygen species consisting mainly of superoxide anion radical (O 2 -), hydrogen peroxide (H 2 O 2 ) and the hydroxyl radicals (OH -) [22] .…”

Section: Discussionmentioning

confidence: 99%

Protection of cadmium chloride induced DNA damage by Lamiaceae plants

Thirugnanasampandan¹,

Jayakumar

2011

Asian Pacific Journal of Tropical Biomedicine

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“…Prenatal exposure to arsenic is associated with later life health effects in adults [96][97][98]. Toxic metal exposures in utero and during childhood may result in significant health effects including, low birth weight, reduced fetal growth and reproductive and cognitive deficits in adolescents [99][100][101]. Results in the appearance of diverse types of cancer, such as hyperkeratosis, lung, and skin cancer.Increased mortality and increased risk [102,103].…”

Section: The Toxicity Of Arsenicmentioning

confidence: 99%

A Review of the Potential Issues of Pollution Caused by the Mineral Elements, Mercury, Lead and Arsenic, Its Possible Impacts on the Human Beings and the Suggested Solutions

Lam¹,

Sze²,

Yao³

et al. 2012

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Objective: This paper mainly discusses and summarises the potential issues of pollution caused by the Mineral elements, Mercury, Lead and Arsenic, its possible impacts on the human beings and the suggested solutions. Methods: This paper is prepared by reviewing the latest academic literatures. Result: First, this article discusses two aspects including the effects of Mercury, Lead and Arsenic on the Chinese herbal medicine and the potential issues of causing the environmental pollution. And then further study its toxicity effects and the side impacts on the human bodies in order to realize the actual circumstances people are encountering nowadays. This paper will also the corresponding its treatment method of reviews. Hope this will provide a valuable reference. Conclusion: Theses issues caused by the Mineral elements are prominent nowadays, thus the ongoing researches on the impacts of pollution and the possible solutions are regarded as highly valued in order to conserve the natural environment and meanwhile safeguard the well beings of people and the future offspring.

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Cadmium: Toxic effects on the reproductive system and the embryo

Cited by 546 publications

References 174 publications

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Protection of cadmium chloride induced DNA damage by Lamiaceae plants

A Review of the Potential Issues of Pollution Caused by the Mineral Elements, Mercury, Lead and Arsenic, Its Possible Impacts on the Human Beings and the Suggested Solutions

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