Caesarean section in a patient with cystic fibrosis

Muammar, M.; Marshall, Philip Guy; Wyatt, Hilary; Skelton, V.

doi:10.1016/j.ijoa.2004.08.003

Cited by 17 publications

(6 citation statements)

References 12 publications

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“…d No abnormal findings in the lung field and no significant change of the diaphragm level, compared with those the day before the operation, were confirmed, immediately after the cesarean section ventilation [4,6,7]. Muammer et al reported that spinal anesthesia (SA) for cesarean section had no negative effects, on both FVC and FEV 1.0 , even in a woman with CF, who had severely impaired pulmonary function [7]. GA could be, however, preferred from the vantage point of preventing respiratory muscle paralysis reaching the high thoracic level, which can be observed concomitant with neuraxial blocks alone.…”

Section: Discussionmentioning

confidence: 91%

“…c On the day before cesarean section, chest X-ray in supine position confirmed no significant displacement of the diaphragm, when considering the impact of the posture on diaphragm position; however, it revealed further increase of vascular shadows in the right lung field. d No abnormal findings in the lung field and no significant change of the diaphragm level, compared with those the day before the operation, were confirmed, immediately after the cesarean section ventilation [4,6,7]. Muammer et al reported that spinal anesthesia (SA) for cesarean section had no negative effects, on both FVC and FEV 1.0 , even in a woman with CF, who had severely impaired pulmonary function [7].…”

Section: Discussionmentioning

confidence: 96%

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Anesthetic considerations for cesarean section in a parturient complicated by Scimitar syndrome-like pathophysiology

et al. 2018

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Background: Pre-existing poor respiratory function is a significant challenge for women to successfully continue pregnancy and accomplish delivery. Case: Pregnancy and delivery were successfully managed without any maternal or neonatal complications, in a 26year-old woman with severely impaired respiratory function, due to a unilateral hypoplastic lung, accompanying Scimitar syndrome-like circulation. Hyperventilation, normally observed even at the first trimester, was absent by the end of the second trimester. This would indicate her ventilation must have reached utmost capacity. Premature delivery by the mode of elective cesarean section delivery was, therefore, the most reasonable option. General anesthesia, combined with a continuous epidural infusion of low-concentrate local anesthetics, containing opioid, was sufficient to avoid the need for unexpected mechanical ventilation in intra-and early postoperative periods and to provide excellent post-partum analgesia. Conclusion: This combination can be a potent alternative in tailoring anesthesia for cesarean section in women with extremely impaired pulmonary reserve.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 96%

Anesthetic considerations for cesarean section in a parturient complicated by Scimitar syndrome-like pathophysiology

et al. 2018

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“…Neuraxial techniques are preferred, and combined spinal-epidural anesthesia for cesarean delivery provides a denser, more predictable surgical block while allowing for postoperative pain relief with an epidural infusion. [119][120][121] ONGOING RESEARCH It is remarkable that in just 50 years, investment in research has led to meaningful improvements in longevity and quality of life. Ongoing clinical trials are focusing on anti-infectives, anti-inflammatories, mucolytics, and novel CFTR modulators for rare genotypes that have no current therapies.…”

Section: Special Considerations Lung Transplantationmentioning

confidence: 99%

The Changing Face of Cystic Fibrosis: An Update for Anesthesiologists

Lee

Huffmyer

Thiele

et al. 2022

Anesthesia &Amp; Analgesia

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Cystic fibrosis (CF) is the most common fatal genetic disease in North America. While CF is more common among Whites, it is increasingly being recognized in other races and ethnicities. Although there is no cure, life expectancy has steadily improved, with the median survival exceeding 46 years in the United States. There are now more adults than children with CF in the United States. CF is caused by mutations in a gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) protein, expressed in many epithelial cells. More than 2100 CFTR mutations have been linked to CF, and newer CFTR modulator drugs are being used to improve the production, intracellular processing, and function of the defective CFTR protein. CF is a multisystem disease that affects primarily the lungs, pancreas, hepatobiliary system, and reproductive organs. Anesthesiologists routinely encounter CF patients for various surgical and medical procedures, depending on the age group. This review article focuses on the changing epidemiology of CF, advances in the classification of CFTR mutations, the latest innovations in CFTR modulator therapies, the impact of the coronavirus disease pandemic, and perioperative considerations that anesthesiologists must know while caring for patients with CF.

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“…41,42,46,[57][58][59] Ideally an obstetrician and an obstetric anaesthetist with an interest in complex pregnancy (better still with accumulated experience of CF pregnancy) and preferably on the same site as the CF centre should be engaged to see the patient early in pregnancy. 41,42,46,[57][58][59] Ideally an obstetrician and an obstetric anaesthetist with an interest in complex pregnancy (better still with accumulated experience of CF pregnancy) and preferably on the same site as the CF centre should be engaged to see the patient early in pregnancy.…”

Section: The Role Of the Obstetric Teammentioning

confidence: 99%

Cystic Fibrosis – A Guide for Clinicians in Reproductive and Obstetric Medicine

Edenborough

Morton

2010

Fet. Matern. Med. Rev.

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Cystic Fibrosis (CF) is the most common life-shortening recessive genetic disease in the UK. Far from being a condition managed exclusively by paediatricians with sufferers dying in early childhood, CF is now a condition in which adults outnumber children with the condition, and the death of a child in a paediatric centre is rare. As increasing numbers of young people grow up relatively healthy it is unsurprising they begin to ask about relationships, sex, fertility and the possibility of having a child. This paper briefly describes the genetics, pathophysiology and clinical features of CF with an emphasis on how it pertains to female reproduction. The management of women with CF considering having a baby including contraception, preparation for pregnancy, the pregnancy itself, delivery and the post natal period will be discussed. Contraindications to pregnancy, method of termination, and pregnancy after transplantation will also be considered. Much of the detailed management is given in the European Guidelines for the Management of Pregnancy in Women with CF on which this paper is based.

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Caesarean section in a patient with cystic fibrosis

Cited by 17 publications

References 12 publications

Anesthetic considerations for cesarean section in a parturient complicated by Scimitar syndrome-like pathophysiology

Anesthetic considerations for cesarean section in a parturient complicated by Scimitar syndrome-like pathophysiology

The Changing Face of Cystic Fibrosis: An Update for Anesthesiologists

Cystic Fibrosis – A Guide for Clinicians in Reproductive and Obstetric Medicine

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