Caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice

Takeda, Hiroshi; Tsuji, Minoru; Yamada, Tomoko; Masuya, Jiro; Matsushita, Kaneaki; Tahara, Masashi; Iimori, Makio; Matsumiya, Teruhiko

doi:10.1016/j.ejphar.2006.01.026

Cited by 51 publications

(31 citation statements)

References 23 publications

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“…In the same way, a recent study of Chai et al (Chai et al 2013) corroborates that caffeic acid upregulates neurotrophins (NGF, BDNF, and GDNF) synthesis and release in hypoxia/ reoxygenation rat astrocytes via p-CREB and p-Akt signaling. Also, it has been proved that caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice (Takeda et al 2006) A B Fig. 6 Stricture of AchE gorge entrance results of docking studies predict that caffeic acid can block partly the gorge entrance.…”

Section: Discussionmentioning

confidence: 97%

Protective effects of caffeic acid against hypothalamic neuropeptides alterations induced by malathion in rat

Rezg

Mornagui

Santos

et al. 2014

Environ Sci Pollut Res

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Exposure to pesticides is suspected to cause human health problems. Our study aimed to evaluate preventive effects of caffeic acid (3,4-dihydroxycinnamic acid) in the hypothalamus against malathion-induced neuropeptides gene expression alterations. Malathion at 100 mg/kg was administered intragastrically to rats alone or in combination with caffeic acid at 100 mg/kg during 4 weeks. A molecular expression of hypothalamic neuropeptides and plasmatic cholinesterase activity was investigated. Furthermore, we used in silico analysis, known as computational docking, to highlight the nature of acetylcholinesterase-malathion/caffeic acid interactions. Our findings showed differences in the responses and indicate that caffeic acid reversed malathion-induced decrease in corticotropin-releasing hormone mRNA but not brain-derived neurotrophic factor which presented an increased tendency. We suggest that caffeic acid can interact with acetylcholinesterase as the primary target of organophosphorus compounds. Results predict that caffeic acid can block partly the acetylcholinesterase gorge entrance via π-π stacking interaction with Tyr 124 and Trp 286 residues of the peripheral site leading to its stricture. Under this condition, we suggested that acetylcholine trafficking toward the catalytic site is ameliorated compared to malaoxon according to their sizes.

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Section: Discussionmentioning

confidence: 97%

Protective effects of caffeic acid against hypothalamic neuropeptides alterations induced by malathion in rat

Rezg

Mornagui

Santos

et al. 2014

Environ Sci Pollut Res

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show abstract

“…Recently neuroprotective effect of caffeic acid has also been suggested (Kalonia et al 2009a, b). Takeda et al have also demonstrated that caffeic acid reduced the duration of immobility period in the forced swimming test and altered expression of BDNF mRNA in the frontal cortex, which suggests its antidepressive-like activity (Takeda et al 2006). Reports from our laboratory also established the antioxidant profile of caffeic acid (Singh et al 2002).…”

Section: Introductionmentioning

confidence: 91%

Potential role of pioglitazone, caffeic acid and their combination against fatigue syndrome-induced behavioural, biochemical and mitochondrial alterations in mice

2010

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Chronic fatigue is an illness characterised by persistent and relapsing fatigue, often accompanied by numerous neuropsychiatric problems, such as anxiety and depression. The aetiology of chronic fatigue remains unclear so far. However, recent studies suggested the involvement of oxidative stress in this chronic debilitating disease. Alternatively, antioxidants have also been reported to have beneficial effect against chronic fatigue-like conditions. Therefore, present study has been designed to explore the potential role of pioglitazone, caffeic acid and their combination against chronic fatigue-like condition in mice. In the experimental protocol, the mice were put on the running wheel apparatus for 6 min test session daily for 21 days which produced fatigue-like condition. The locomotor activity and anxiety levels were measured on 0, 8th, 15th and 22nd days. The brains were isolated on 22nd day immediately after the behavioural assessments, oxidative damage and mitochondrial enzyme complexes were then estimated subsequently. Three weeks pioglitazone (5 and 10 mg/kg) and caffeic acid (5 and 10 mg/kg) pretreatment significantly attenuated the chronic fatigue-like condition (restored running wheel activity, locomotor activity and reduced anxiety-like behaviour) as compared to that in control (chronic fatigue) animals. Further, pioglitazone (5 and 10 mg/kg) and caffeic acid (5 and 10 mg/kg) drug treatments for 3 weeks significantly attenuated oxidative damage (decreased lipid peroxidation, nitrite concentration, restored reduction in glutathione and catalase levels), altered mitochondrial enzymes complex (I, II and IV) activities and mitochondrial redox activity (MTT assay) when compared with control. Further, combination of lower dose of pioglitazone (5 mg/kg) and caffeic acid (5 mg/kg) showed significant synergism in their protective effect which was significant as compared to their effect per se. The present study highlights the potential role of pioglitazone, caffeic acid and their combination in the pathophysiology of chronic fatigue-like condition in mice.

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“…The common animal model of depression is Forced swimming test (FST) because it induces a depressive-like manner to conceal antidepressant effect of chemicals and can conclude depressive-like behavior in rats after exposure to other stressors [5]. FST explains a stressing situation which capable of creating a state of lower habit, reflected in the motionlessness induced in animals.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like Effects of Aqueous Extract of Salvadora persica in Rat Model of Depression

Ramadan¹,

Farid²

2016

J Diabetes Metab

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Salvadora persica (SP) has been used as a medicinal purpose among global Muslim community. Various phytochemical studies on SP reported the presence of saponins, flavonoids, steroids, phenols and tannins. Flavonoids are responsible for antimicrobial, antiallergic, antioxidant, antiradial, anti-inflammatory and antiproliferative activity. The present study was carried out to evaluate the antidepressant activity of aqueous extract of SP on forced swimming test on male albino rats after four weeks treatment. The effect was assessed by immobility time, body weight, vital organ weight, blood glucose, and degree of DNA fragmentation that might happen in leukocyte due to depression. These activities were tested at dose of 900 mg/kg extracts of SP administered orally for 28 successive days. Rats were divided into two groups (12 animals/group): control group (distilled water) and extract group (SP aqueous extract at 900 mg/kg PO for two weeks. On day 14, animals will be further classified into four equal groups (six animals each): Undepressed control, depressed rats, extract plus undepressed rats and extract plus depressed for next two weeks. The samples were administered via gavage through oral route. The weight of the animals will be measured every week. It was found that extract significantly (p<0.001) increases mobility time in rats. It also showed significant (p<0.001) decreased in blood glucose and DNA fragmentation as compared to depressed group. The obtained results revealed that SP extract has got significant antidepressant activity. Hence, aqueous extract of SP may be explored further for the management of mental depression.

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Caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice

Cited by 51 publications

References 23 publications

Protective effects of caffeic acid against hypothalamic neuropeptides alterations induced by malathion in rat

Protective effects of caffeic acid against hypothalamic neuropeptides alterations induced by malathion in rat

Potential role of pioglitazone, caffeic acid and their combination against fatigue syndrome-induced behavioural, biochemical and mitochondrial alterations in mice

Antidepressant-like Effects of Aqueous Extract of Salvadora persica in Rat Model of Depression

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