Caffeic acid phenethyl ester ameliorates imidacloprid-induced acute toxicity in the rat cerebral cortex

Eser, Nadire; Çiçek, Mustafa; Yoldaş, Atila; Demır, Mehmet; Deresoy, Faik Alev

doi:10.1016/j.etap.2022.103980

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…However, no morphological changes in astrocytes were detected, indicating the importance of molecular biomarkers. A decrease in GFAP levels was also observed in the rat cerebral cortex after administration of 100 mg/kg imidacloprid (Eser et al, 2022). In the study of Sidiropoulou et al (2009), the metabolite of the organophosphorus insecticide diazinon (diazinon oxon, DZO) after 24 hours of exposure caused a decrease in GFAP expression in differentiated rat C6 glioma cells in vivo.…”

Section: Discussionmentioning

confidence: 94%

Low doses of imidacloprid induce neurotoxic effects in adult marsh frogs: GFAP, NfL, and angiostatin as biomarkers

Yermolenko

Nedzvetsky

Gasso

et al. 2022

Regul. Mech. Biosyst.

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Imidacloprid is one of the most widely used insecticides in the world. The neurotoxicity of imidacloprid in adult amphibians has not been studied thoroughly. We investigated the expression of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) and angiostatin in the amphibian brain to identify valid biomarkers of low dose imidacloprid exposure. For the experiment, 30 individuals of the marsh frog Pelophylax ridibundus were selected. The amphibians were divided into five groups. The duration of the experiment was 7 and 21 days. The exposure concentrations were 10 and 100 µg/L. The results of the study revealed a decrease in the expression of GFAP after 7 days in the exposure groups of 10 and 100 μg/L. An increase in the level of NfL was observed in the group exposed to 10 μg/L after 21 days of the experiment. The angiostatin level was increased after 7 days at 10 µg/L and after 21 days at 100 µg/L. The data obtained indicate that low concentrations of imidacloprid can cause neurotoxic effects in the brain of P. ridibundus. Such effects can have a significant impact on amphibian populations. According to the results of the study of the expression level of GFAP, NfL and angiostatin, it can be stated that imidacloprid has a neurotoxic effect on adult marsh frogs. The studied indicators can be promising biomarkers of environmental pollution by neonicotinoids.

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Section: Discussionmentioning

confidence: 94%

Low doses of imidacloprid induce neurotoxic effects in adult marsh frogs: GFAP, NfL, and angiostatin as biomarkers

Yermolenko

Nedzvetsky

Gasso

et al. 2022

Regul. Mech. Biosyst.

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“…Additionally, NNIs are also used as veterinary drugs (VMPs) (EC 2023). Imidacloprid (IMI), chemically known as 1H-Imidazol-2-amine, 1-[(6-chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-(EPA 2023) functions as a partial agonist NNI with recognized e cacy in exerting broad-spectrum insecticidal activity (Déglise et al 2002;Tan et al 2007;Eser et al 2022). As a systemic chloro-nicotinil coumpond (Diypestcontrol 2022), IMI exhibits high solubility in water, presenting a high risk concerning groundwater contamination due to leaching and low Koc (sorption constant normalized for organic carbon content) (132 to 310) (IBAMA 2023).…”

Section: Introductionmentioning

confidence: 99%

Assessing the ecotoxicity of commercial formulation based on Imidacloprid on the non-target freshwater planarian Girardia tigrina

de Oliveira,

Pedroso,

Rodrigues

et al. 2024

Preprint

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Imidacloprid (IMI) is among the most frequently detected insecticides in freshwater ecosystems near agricultural areas where it affects not only target insects, but also other non-target organisms. This study aimed to investigate the acute and chronic toxicity of a commercial insecticide formulation that uses imidacloprid as the active ingredient (Imidagold 700 WG®) on the non-target planarian Girardia tigrina. The ecotoxicological tests performed evaluated the survival, locomotor velocity, regeneration, and reproduction of planarians. In the acute toxicity test, the organisms were exposed to various concentrations of IMI ranging from 50 mg a.i./L to 527 mg a.i./L alongside a control treatment (ASTM only). For the chronic effect toxicity evaluation, planarians were exposed to concentrations ranging from 100 to 1,600 µg a.i./L in addition to the control treatment (ASTM, only). The estimated LC50 at 24 and 48 hours for IMI was 114 and 94.29 mg a.i./L, showing low acute toxicity. However, decreased locomotor velocity and delayed regeneration of photoreceptors and auricles were observed for environmentally relevant concentrations equal or higher than 200 µg a.i./L. Reproduction was significantly impacted at the concentration of 200 µg a.i./L but not affected at higher concentrations, suggesting hormesis. Considering the planarians' importance in freshwater ecosystems and their position in the food chain, the detrimental effects induced by IMI may extend to freshwater communities and overall ecosystem functioning.

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Caffeic acid phenethyl ester attenuates indomethacin-induced gastric ulcer in rats

Neamatallah

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Caffeic acid phenethyl ester ameliorates imidacloprid-induced acute toxicity in the rat cerebral cortex

Cited by 5 publications

References 56 publications

Low doses of imidacloprid induce neurotoxic effects in adult marsh frogs: GFAP, NfL, and angiostatin as biomarkers

Low doses of imidacloprid induce neurotoxic effects in adult marsh frogs: GFAP, NfL, and angiostatin as biomarkers

Assessing the ecotoxicity of commercial formulation based on Imidacloprid on the non-target freshwater planarian Girardia tigrina

Caffeic acid phenethyl ester attenuates indomethacin-induced gastric ulcer in rats

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