Caffeic acid phenethyl ester and its related compounds limit the functional alterations of the isolated mouse brain and liver mitochondria submitted to in vitro anoxia–reoxygenation: Relationship to their antioxidant activities

Feng, Yan; Ying-wei, LU; Xu, Pingwen; Long, Yuan; Wu, Wei-Min; Li, Wei; Wang, Rui

doi:10.1016/j.bbagen.2008.01.002

Cited by 36 publications

(30 citation statements)

References 57 publications

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“…Thus, in both membrane systems CAPE showed the highest antioxidant activity followed by ethyl ferulate, caffeic and ferulic acid indicating the involvement of side chain with the phospholipid bilayer of the membrane. In line with these findings, Feng et al (2008) reported that CAPE and caffeic acid were potent antioxidants against mouse brain and liver mitochondria injury induced by in vitro anoxia-reoxygenation compared to ferulic acid and ethyl ferulate. Caffeic acid phenethyl ester demonstrated potent antioxidant activities against human fibrosarcoma cell metastasis (Hwang et al 2006), 6-hydroxydopamine-induced rat neuronal death , growth of human leukemia HL-60 cells (Chen et al 1996), cytotoxicity in oral cancer cells (Lee et al 2003), cytotoxicity in C6 glioma cells (Lee et al 2003) in many in vitro cellular assays.…”

Section: Caffeic Acid and Derivativessupporting

confidence: 50%

Hydroxycinnamates and their in vitro and in vivo antioxidant activities

2009

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Hydroxycinnamates are among the most widely distributed plant phenylpropanoids present in the free, conjugated-soluble and insoluble-bound forms. This review will focus on the occurrence, in vitro and in vivo antioxidant activities of ferulic, coumaric, caffeic and sinapic acids and their derivatives. Hydroxycinnamates are found in almost all food groups though they are abundant in cereals, legumes, oilseeds, fruits, vegetables and beverages and render antioxidant activity by scavenging hydroxyl radical, superoxide radical anion, several organic radicals, peroxyl radical, peroxinitrite and singlet oxygen, among others. Further, their antioxidant activity as chain breaking antioxidants and reducing agents is also notable. Ferulic acid and its derivatives such as ferulic acid ethyl ester, ferulic acid dehydrodimers, feruloyl glycosides and curcumin have demonstrated potent antioxidant activity in both in vitro and in vivo systems. Similarly, caffeic acid and some of its derivatives such as caffeic acid phenethyl ester, rosmarinic acid, and chlorogenic acid exhibit antioxidant activity. The highest antioxidant activity was observed for caffeic acid whereas p-coumaric acid had the least effect among major hydroxycinnamic acids. The importance of structural effects on the potency of antioxidant activity of hydroxycinnamates is discussed. While this review also shows the existence of substantial body of evidences for in vitro antioxidant activity of hydroxycinnamates, there is a clear gap for in vivo information, particularly for sinapic and p-coumaric acids and their derivatives. The role of grains, fruits, vegetables and red wine in disease risk reduction and health promotion could partly be attributed to their constituent hydroxycinnamates. KeywordsCaffeic Á Ferulic Á In vitro antioxidant activity Á In vivo studies Á Sinapic Abbreviations AAPH 2, 2 0 -Azobis-(2-methyl propionamidine) dihydrochloride diFA Dehydrodiferulic acid CAPE Caffeic acid phenethyl ester DPPH 1, 1-Diphenyl 2-picrylhydrazil DOPAC 3, 4-Dihydroxyphenylacetic acid FAEE Ferulic acid ethyl ester FRAP Ferric reducing antioxidant power IR Ischaemia-reperfusion LPS Lipopolysacchride LDL Low density lipoprotein NO Nitric oxide TPA 12-O-Tetradecanoylphorbol-13-acetate TEAC Trolox equivalent antioxidant capacity TBARS Thiobarbituric reactive substances

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Section: Caffeic Acid and Derivativessupporting

confidence: 50%

Hydroxycinnamates and their in vitro and in vivo antioxidant activities

2009

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“…The co-administration of OOHF improved anti-oxidant activities against lung injury. This could suggest that EVOO contains a considerable amount of phenols like oleuropein, hydroxytyrosol, tyrosol, and caffeic acid might perform a lung protective effect against toxicity by scavenging ROS (Owen et al 2000;Feng et al 2008). The coexposure to Al and ACR is also characterized by the depletion of lung non-enzymatic anti-oxidants including glutathione (GSH), non-protein thiols (NPSH), and vitamin C. In fact, NPSH are intra-cellular anti-oxidants in some compartments such as the epithelial lining fluid of the lung (Srinivasan et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Dietary unsaponifiable fraction of extra virgin olive oil supplementation attenuates lung injury and DNA damage of rats co-exposed to aluminum and acrylamide

Ghorbel

Chaâbane

Boudawara

et al. 2016

Environ Sci Pollut Res

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Aluminum chloride (AlCl3) and acrylamide (ACR) are well known as environmental pollutants inducing oxidative stress. Our study investigated the effects of these contaminants and if the hydrophilic fraction of extra virgin olive oil was able to prevent lung oxidative stress and DNA damage. Animals were divided into four groups of six each: group 1, serving as controls, received distilled water; group 2 received in drinking water aluminum chloride (50 mg/ kg body weight) and by gavage acrylamide (20 mg/kg body weight); group 3 received both aluminum and acrylamide in the same way and the same dose as group 2 and hydrophilic fraction from olive oil (OOHF) (1 ml) by gavage; group 4 received only OOHF by gavage. Exposure of rats to both aluminum and acrylamide provoked oxidative stress in lung tissue based on biochemical parameters and histopathological alterations. In fact, we have observed an increase in malondialdehyde (MDA), H2O2, and advanced oxidation protein product (AOPP) and a decrease in reduced glutathione (GSH), non-protein thiols (NPSH), and vitamin C levels. Activities of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) were also decreased. Histopathological changes in lung tissue were noted like emphysema, vascular congestion, and infiltration of inflammatory cells. A random DNA degradation was observed on agarose gel in the lung of AlCl3 and acrylamide (ACR)-treated rats. Co-administration of OOHF to treated rats improved biochemical parameters to near control values and lung histoarchitecture. The smear formation of genomic DNA was reduced. The hydrophilic fraction of extra virgin olive oil might provide a basis for developing a new dietary supplementation strategy in order to prevent lung tissue damage.

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“…Hydroxytyrosol is highly effective against DNA damage by peroxynitrite in vitro (Deiana et al, 1999). Caffeic acid phenethyl ester and its related compounds limit the functional alterations of the isolated mouse brain and liver mitochondria submitted to in vitro anoxiareoxygenation (Feng et al, 2008). Lipid peroxidation is the process of oxidative degradation of PUFA and its incidence in biological membranes resulting in impaired membrane function, structural integrity, decreased membrane fluidity and the inactivation of several membrane-bound enzymes (Gutteridge and Halliwell, 2000).…”

Section: Discussionmentioning

confidence: 99%

EFFECT OF VIRGIN OLIVE OIL (<i>OLEA EUROPEA</i>. L) ON KIDNEY FUNCTION IMPAIRMENT AND OXIDATIVE STRESS INDUCED BY MERCURIC CHLORIDE IN RATS

Necib¹

2013

American Journal of Biochemistry and Biotechnology

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The study was designed to investigate the possible protective role of virgin olive oil in mercuric chloride induced renal stress, by using biochemical approaches. The effects of virgin olive oil on mercuric chloride induced oxidative and renal stress were evaluated by serum creatinine, urea and uric acid levels, kidney tissue lipid peroxidation, GSH levels, GSH-Px and GST activities. Administration of mercuric chloride induced significant increase in serum: interleukine1, interleukine6 and Tumor Necrosis Factor α (TNFα) levels, creatinine, urea and uric acid concentration showing renal stress. Mercuric chloride also induced oxidative stress, as indicate by decreased kidney tissue of GSH level, GSH-Px and GST activities along with increase the level of lipid peroxidation. Furthermore, treatment with mercuric chloride caused a marked elevation of kidney weight and decreased body weight. Virgin olive oil treatment markedly reduced elevated serum: IL1, IL6, TNFα, creatinine, urea and uric acid levels and conteracted the deterious effects of mercuric chloride on oxidative stress markers changes caused by HgCl 2 in kidney. Our results indicate that virgin olive oil could have a beneficial role against mercuric chloride induced oxidative and renal stress in rat.

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Caffeic acid phenethyl ester and its related compounds limit the functional alterations of the isolated mouse brain and liver mitochondria submitted to in vitro anoxia–reoxygenation: Relationship to their antioxidant activities

Cited by 36 publications

References 57 publications

Hydroxycinnamates and their in vitro and in vivo antioxidant activities

Hydroxycinnamates and their in vitro and in vivo antioxidant activities

Dietary unsaponifiable fraction of extra virgin olive oil supplementation attenuates lung injury and DNA damage of rats co-exposed to aluminum and acrylamide

EFFECT OF VIRGIN OLIVE OIL (<i>OLEA EUROPEA</i>. L) ON KIDNEY FUNCTION IMPAIRMENT AND OXIDATIVE STRESS INDUCED BY MERCURIC CHLORIDE IN RATS

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