Caffeic Acid: Potential Applications in Nanotechnology as a Green Reducing Agent for Sustainable Synthesis of Gold Nanoparticles

Seo, Yu Seon; Cha, Song-Hyun; Yoon, Hye‐Ran; Kang, Younhee; Park, Youmie

doi:10.1177/1934578x1501000424

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…As we reported previously, CA-AuNPs synthesized using a caffeic acid concentration of 0.20 mM possessed a face-centered cubic structure [30]. In this study, CA-AuNPs that were synthesized using a caffeic acid concentration of 0.08 mM exhibited the best activity among the tested concentrations; thus, crystalline nature was again confirmed by HR-XRD pattern (Fig.…”

Section: Resultssupporting

confidence: 83%

Catalytic reduction of 4-nitrophenol with gold nanoparticles synthesized by caffeic acid

et al. 2017

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In this study, various concentrations of caffeic acid (CA) were used to synthesize gold nanoparticles (CA-AuNPs) in order to evaluate their catalytic activity in the 4-nitrophenol reduction reaction. To facilitate catalytic activity, caffeic acid was removed by centrifugation after synthesizing CA-AuNPs. The catalytic activity of CA-AuNPs was compared with that of centrifuged CA-AuNPs (cf-CA-AuNPs). Notably, cf-CA-AuNPs exhibited up to 6.41-fold higher catalytic activity compared with CA-AuNPs. The catalytic activity was dependent on the caffeic acid concentration, and the lowest concentration (0.08 mM) produced CA-AuNPs with the highest catalytic activity. The catalytic activities of both CA-AuNPs and cf-CA-AuNPs decreased with increasing caffeic acid concentration. Furthermore, a conversion yield of 4-nitrophenol to 4-aminophenol in the reaction mixture was determined to be 99.8% using reverse-phase high-performance liquid chromatography. The product, 4-aminophenol, was purified from the reaction mixture, and its structure was confirmed by 1H-NMR. It can be concluded that the removal of the reducing agent, caffeic acid in the present study, significantly enhanced the catalytic activity of CA-AuNPs in the 4-nitrophenol reduction reaction.

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Section: Resultssupporting

confidence: 83%

Catalytic reduction of 4-nitrophenol with gold nanoparticles synthesized by caffeic acid

et al. 2017

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“…Seo et al . (2015) also demonstrated the green synthesis of AuNPs using caffeic acid as a reductant. Simply, HAuCl 4 (200 mL, 1 m m ) was added slowly in the preheated caffeic acid (0.8 mL, 0.25 m m ) with continuous stirring for 3 min.…”

Section: Pcs‐mediated Synthesis Of Aunpsmentioning

confidence: 99%

Phenolic compounds mediated biosynthesis of gold nanoparticles and evaluation of their bioactivities: A review

Huang

Devi

Bordiga

et al. 2023

Int J of Food Sci Tech

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Summary Gold nanoparticles (AuNPs) have been applied in a variety of fields based on their unique physical and chemical properties. Phenolic compounds (PCs) are the largest variety of phytochemicals in foods and have received substantial attention owing to their extraordinary health benefits. Recently, extensive studies have been conducted on the synthesis and conjugation of PCs onto AuNPs (AuNP/PC) characterisation, their bioactivities such as antimicrobial, anticancerous, anti‐inflammatory. PCs served the dual roles, i.e., as reductant and stabiliser during the synthesis of AuNPs/PC in a one‐pot process. The synthesis parameters for AuNP/PCs and the characteristic properties of as‐synthesised AuNP/PCs should be evaluated to achieve the highly efficient bioactivities. Therefore, the critical criteria for the synthesis of AuNP/PC such as the temperature, pH, and molar ratio of the precursors are reviewed. It is found that the PCs mediated reduction of gold salt can provide the well dispersed and stable AuNPs with a high negative surface charge (−15 to −54 mV) and an average SPR band ranging from 520 to 600 nm. The presence of surface hydroxyl groups in AuNP/PCs was the indication of successful conjugation of PCs with AuNPs. It can be concluded that the synergistic effect of the PCs‐conjugated AuNPs greatly enhanced their bioactivities.

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“…Therefore, a more effective topical formulation is needed. Several studies of nano-based caffeic acid such as nanoencapsulations, nanoparticles, nanoemulsions, and other lipid nanocarriers have been carried out [11], [12], [13], [14]. The application of nanoemulsion technology has been increasingly applied as an effective topical drug carrier, has many benefits in various applications due to its characteristic properties, small droplet size (in the range of 20-500 nm) with the high interfacial area, high storage stability, low preparation cost, thermodynamic stability, transparent appearance, high solubilization capacity, low viscosity, high kinetic, sedimentation stability, flocculation, and in some cases coalescence [15], [16], [17].…”

Section: Introductionmentioning

confidence: 99%

Development of Propolis (Apis trigona)-loaded Nanoemulgel for Improved Skin Penetration of Caffeic Acid: The Effect of Variation of Oleic Acid Concentration

Viqhi

Manggau

Sartini

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Propolis contains caffeic acid compounds, which are proven to have pharmacological effects as an anti-inflammatory. However, its effectiveness is hampered by the poor solubility of caffeic acid. Here, we report developing the nanoemulgel approach containing propolis extract as an active ingredient and oleic acid as a permeation enhancer for transdermal delivery of caffeic acid. AIM: This study aims to determine the effect of oleic acid concentration on increasing caffeic acid permeation in the skin and obtain a nanoemulgel formula with desired physical characteristics and stability. MATERIALS AND METHODS: Propolis was macerated with 70% ethanol; the total phenolic content was measured by ultraviolet–visible spectrophotometer, and the levels of caffeic acid in the extracts and nanoemulgel preparations were finally determined using ultra-fast liquid chromatography. Formulas were made using various concentrations of oleic acid, namely, 1.25%w/w (Formula F1); 2.5%w/w (Formula F2); 5%w/w (Formula F3), respectively; and 1.25%w/w without propolis extract (Formula F4) as a comparison. RESULTS: The results obtained from analysis of variance statistical exhibited that the difference in oleic acid concentrations in four formulas significantly affected (p < 0.05) particle size, polydispersity index, spreadability, adhesion, freeze-thaw, permeation, and retention test. However, there was no significant difference (p > 0.05) on pH and viscosity before and after 4 weeks of storage and zeta potential test. The highest amount of permeation and retention was found in F3 and F2, respectively, and all formulas tended to follow zero-order drug release kinetics. Furthermore, the results showed that the number of percent’s permeated in a row was 3.74% (F1); 5.58% (F2); 11.67% (F3), and F2 was the formula with the most optimal retention amount with a percentage of 43.13% at 24 h. CONCLUSION: This study shows a promising delivery system for increasing the effectiveness of natural lipophilic compounds to treat inflammation in the skin.

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Caffeic Acid: Potential Applications in Nanotechnology as a Green Reducing Agent for Sustainable Synthesis of Gold Nanoparticles

Cited by 5 publications

References 23 publications

Catalytic reduction of 4-nitrophenol with gold nanoparticles synthesized by caffeic acid

Catalytic reduction of 4-nitrophenol with gold nanoparticles synthesized by caffeic acid

Phenolic compounds mediated biosynthesis of gold nanoparticles and evaluation of their bioactivities: A review

Development of Propolis (Apis trigona)-loaded Nanoemulgel for Improved Skin Penetration of Caffeic Acid: The Effect of Variation of Oleic Acid Concentration

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