Caffeine: A potential strategy to improve survival of neonatal pigs and sheep

Swinbourne, Alyce M.; Kind, Karen L.; Flinn, Tom; Kleemann, David O.; Wettere, W. H. E. J. van

doi:10.1016/j.anireprosci.2021.106700

Cited by 9 publications

(6 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Robertson et al [40] mention that the main cause of acidemia in animals is hypercapnia, which is a recurrent event in newborn piglets. Swinbourne et al [2] describe that the decrease in maternal blood flow to the fetus significantly affects gas exchange, leading to suboptimal O 2 levels, elevated pCO 2 concentrations, and respiratory acidosis. The decrease in blood pH triggers compensatory mechanisms such as the formation of HCO 3 − when CO 2 and H 2 O are metabolized by carbonic anhydrase [41,42].…”

Section: Discussionmentioning

confidence: 99%

“…a,b,c,d Different letters indicate significant differences between treatments in the same evaluation time. 1,2,3,4 Different numbers indicate significant differences between evaluation times in a single treatment. n = 120 piglets per each group.…”

Section: Blood Gas Parametersmentioning

confidence: 99%

“…Similarly, it was observed that only G 4 registered a statistically significant progressive increase of 12.28 mg/dL at 1 h, 15.28 mg/dL at 6 h, and 40.25 mg/dL at 24 h (p = 0.02) a,b,c,d Different letters indicate significant differences between treatments in the same evaluation time. 1,2,3 Different numbers indicate significant differences between evaluation times in a single treatment. n = 120 piglets per each group.…”

Section: Physio-metabolic Profilementioning

confidence: 99%

“…Newborn mortality in piglets ranges from 15 to 70% during the first three days postfarrowing [1], and from 11 to 20% in the pre-weaning period [2]. Several factors influence the high mortality rates.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Caffeine Administration in Piglets with Low Birthweight and Low Vitality Scores, and Its Effect on Physiological Blood Profile, Acid–Base Balance, Gas Exchange, and Infrared Thermal Response

Villanueva-García,

Ghezzi,

Mora-Medina

et al. 2023

Animals

View full text Add to dashboard Cite

Intrapartum asphyxia, fetal hypoxia, and their consequences (e.g., acidosis, hypercapnia, hypoglycemia, and hypothermia) are the main factors related to physio-metabolic imbalances that increase neonatal mortality in piglets, particularly in piglets with low birthweight and low vitality scores. This study aimed to evaluate the effect of three different doses of caffeine (10, 20, and 30 mg/kg) administered orally to 480 newborn piglets with low birthweight and low vitality scores. Blood gas parameters (pH, pO2, pCO2, and HCO3−), physio-metabolic profile (Ca++, glucose, and lactate), and the thermal response assessed through infrared thermography in four thermal windows (ocular, auricular, snout, and hindlimb) and rectal temperature were evaluated during the first 24 h of life. Doses of 30 mg/kg resulted in significant differences at 24 h for all evaluated parameters, suggesting that caffeine administration improved the cardiorespiratory function and metabolic activity of piglets by reducing acidosis, restoring glycemia, and increasing surface and rectal temperature. In conclusion, caffeine at 30 mg/kg could be suggested as an appropriate dose to use in piglets with low birthweight and low vitality scores. Future research might need to study the presentation of adverse effects due to higher caffeine concentrations.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Blood Gas Parametersmentioning

confidence: 99%

Section: Physio-metabolic Profilementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Caffeine Administration in Piglets with Low Birthweight and Low Vitality Scores, and Its Effect on Physiological Blood Profile, Acid–Base Balance, Gas Exchange, and Infrared Thermal Response

Villanueva-García,

Ghezzi,

Mora-Medina

et al. 2023

Animals

View full text Add to dashboard Cite

show abstract

“…The effects of late-gestation caffeine supplementation to the sow on piglets during and immediately after birth have begun to be noticed in recent years. Caffeine has a chemical structure which allows it to cross the placenta and act directly on piglets in utero, where it is documented to have positive effects on the thermoregulatory capacity of piglets as well as provide protection from hypoxia, a major cause of death in piglets born late in parturition [7][8][9]. In a trial by Dearlove et al (2018), supplementing sow feed with 6 g of caffeine (CAF) per day from day 112 of gestation increased gestation length (CON: 115.6 ± 0.26, CAF: 116.6 ± 0.25, and p < 0.05), decreased the total percentage of stillborn piglets (CON: 6.2%, CAF: 2.6%, and p < 0.05), and decreased the percentage of sows giving birth to stillborn piglets (CON: 43.3%, CAF: 20.6%, and p < 0.05).…”

Section: Caffeinementioning

confidence: 99%

Identifying Suitable Supplements to Improve Piglet Survival during Farrowing and Lactation

Threadgold

Greenwood

Wettere

2021

Animals

View full text Add to dashboard Cite

Piglet mortality during parturition and prior to weaning is an ongoing economic and welfare issue. This review collates the current literature describing the effects of specific dietary supplements on key parameters affecting piglet survival. Four distinct parameters were identified as having a direct impact on the survival of piglets to weaning: stillbirth rate, birth weight and weight variation, daily gain and weaning weight, and colostrum and milk quality. In the primary stage, relevant literature from the past 5 years was reviewed, followed by a secondary review of literature older than 5 years. The focal parameters benefitted from different supplements. For example, stillbirth may be reduced by supplements in late gestation, including forms of arginine, alpha-tocopherol-selenium, uridine, and Saccharomyces cerevisiae yeast culture, whereas average daily gain and weaning weight were related closely to supplements which improved colostrum and milk quality, most commonly fats and fatty acids in the form of n-3 polyunsaturated fatty acids, soybean oil, and fish oil, and polysaccharides, such as ginseng polysaccharide. Therefore, an effective supplement plan for piglet mortality reduction must consider the circumstances of the individual system and target one or more of the highlighted parameters.

show abstract

Evaluation of the therapeutic effect and dose–effect of Bifidobacterium breve on the primary Clostridioides difficile infected mice

Yang

2021

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Caffeine: A potential strategy to improve survival of neonatal pigs and sheep

Cited by 9 publications

References 124 publications

Caffeine Administration in Piglets with Low Birthweight and Low Vitality Scores, and Its Effect on Physiological Blood Profile, Acid–Base Balance, Gas Exchange, and Infrared Thermal Response

Caffeine Administration in Piglets with Low Birthweight and Low Vitality Scores, and Its Effect on Physiological Blood Profile, Acid–Base Balance, Gas Exchange, and Infrared Thermal Response

Identifying Suitable Supplements to Improve Piglet Survival during Farrowing and Lactation

Evaluation of the therapeutic effect and dose–effect of Bifidobacterium breve on the primary Clostridioides difficile infected mice

Contact Info

Product

Resources

About