Evaluation of the therapeutic effect and dose–effect of Bifidobacterium breve on the primary Clostridioides difficile infected mice

Yang, Jingpeng; Yang, Hong

doi:10.1007/s00253-021-11668-2

Cited by 11 publications

(8 citation statements)

References 61 publications

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“…Interestingly, for the second axis of the 7-day-old chicks’ metabolites, the groups that received the multistrain probiotic displayed lower concentrations of Prostaglandin-F-2-α serinol amide, phytosphingosine, and peptides in the feces ( Table 2 , Supplementary Figure 4 ). Prostaglandins F2 is considered an oxidative stress biomarker ( Yao and Narumiya, 2019 ), with studies showing that prostaglandin F2 increased with Eimeria maxima occurrence ( Petrone-Garcia et al, 2021 ); phytosphingosine is associated with inflammatory response and may even increase neutrophil recruitment; for example, in mice infected with Clostridium difficile had also higher levels of phytosphingosine in feces ( Yang and Yang, 2021 ), similar to our findings. Therefore, our results indicate that the probiotic has a protector effect, probably enhancing overall immunity in both infected and uninfected groups with SH, since without blend, individuals had higher levels of metabolites that were associated with higher oxidative stress and overall inflammation.…”

Section: Resultssupporting

confidence: 88%

Harnessing probiotics capability to combat Salmonella Heidelberg and improve intestinal health in broilers

Hoepers,

Nunes,

Almeida-Souza

et al. 2024

Poultry Science

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Section: Resultssupporting

confidence: 88%

Harnessing probiotics capability to combat Salmonella Heidelberg and improve intestinal health in broilers

Hoepers,

Nunes,

Almeida-Souza

et al. 2024

Poultry Science

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“…In this work, a logistic regression model indicated that the increase in the Bifidobacterium levels was associated with a significant reduction in both GI and RT infections. It has been repeatedly reported that gut bifidobacteria participate in the barrier effect against enteric pathogens through different mechanisms, including antimicrobial activity, enhancement of immune responses, and/or regulation of the signaling pathways involved in the integrity of the tight-junction barrier [ 61 , 62 , 63 , 64 , 65 ]. It has been reported that two B. breve strains alleviated DSS-induced colitis in a murine model by maintaining the intestinal epithelial barrier, inhibiting the inflammatory cytokines, and modifying the composition of the gut microbiome [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Safety and Beneficial Health Effects of the Human-Milk Strain Bifidobacterium breve DSM32583: An Infant Pilot Trial

Alba,

Carrera,

Álvarez-Calatayud

et al. 2024

Nutrients

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Human milk promotes the growth of bifidobacteria in the infant gut. Adding bifidobacterial species to infant formula may contribute to increasing their presence in the gut of formula-fed infants. Therefore, the safety and anti-infectious effects of Bifidobacterium breve DSM32583, a breast milk isolate, were assessed in a pilot trial involving 3-month-old infants. The infants were randomly assigned to either the probiotic (PG) or the control (CG) groups. All the infants consumed the same formula, although it was supplemented with the strain (1 × 107 cfu/g of formula) in the PG. Overall, 160 infants (80 per group) finished the intervention. Infants in CG gained more weight compared to PG (p < 0.05), but the weights for age Z-scores at 6 months were within the normal distribution for this age group. The rates of infections affecting the gastrointestinal and respiratory tracts and antibiotic therapy were significantly lower in the PG. The bifidobacterial population and the level of short-chain fatty acids were higher (p < 0.05) in the fecal samples of PG infants. No adverse events related to formula consumption were observed. In conclusion, the administration of an infant formula with B. breve DSM32583 was safe and exerted potential beneficial effects on gut health.

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“…The relative abundance of genus Prevotella 9 was 11–21.82%, but the colonization rate in both SPF and GF mice was only 0.01–0.09%. According to a previous study, Bifidobacterium can regulate the intestinal flora, prevent Clostridioides difficile infection, and improve intestinal health ( Yang and Yang, 2021 ). Prevotella 9 exerts a pro-inflammatory effect and may cause infection ( Tett et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

A study on the method and effect of the construction of a humanized mouse model of fecal microbiota transplantation

et al. 2022

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The gestation period is critical for the health of the mother and fetus. Malnutrition or over nutrition during pregnancy may cause gestational diseases that can result in adverse pregnancy outcomes. Fecal microbiota transplantation (FMT) can be used to re-establish new gut microbiota to treat a variety of diseases and construct a model to investigate the nutritional health during pregnancy. Therefore, this study investigated whether human-derived gut microbiota during pregnancy could colonize the intestines of mice. Moreover, we determined the time and method of intervention for FMT. Based on this information, a humanized mouse model of FMT was constructed to simulate the human intestinal microecology during pregnancy, and serve as a useful animal model for the study of nutritional health and disease during pregnancy. Germ-free (GF) and specific pathogen free (SPF) C57BL/6J mice were selected for humanized gestational FMT and the transplantation outcomes were evaluated. The results demonstrated that the gestational intestinal microbiota colonized the intestines of mice, allowing researchers to construct a humanized mouse model of gestational FMT. The main intestinal flora of the gestational period were transplanted into GF mice, with the gestational flora being similar to the flora of GF mice after transplantation. However, antibiotics could not eliminate the original microbial flora in SPF mice, and the flora was complex and variable after FMT with little increase in abundance. Background flora had a significant impact on the outcomes assessment. The results were better in GF mice than in SPF mice, and after microbiota transplantation, a superior effect was observed on day 21 compared to days 7 and 14.

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Evaluation of the therapeutic effect and dose–effect of Bifidobacterium breve on the primary Clostridioides difficile infected mice

Cited by 11 publications

References 61 publications

Harnessing probiotics capability to combat Salmonella Heidelberg and improve intestinal health in broilers

Harnessing probiotics capability to combat Salmonella Heidelberg and improve intestinal health in broilers

Evaluation of Safety and Beneficial Health Effects of the Human-Milk Strain Bifidobacterium breve DSM32583: An Infant Pilot Trial

A study on the method and effect of the construction of a humanized mouse model of fecal microbiota transplantation

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