Caffeine and muscarinic antagonists act in synergy to inhibit haloperidol-induced catalepsy

Moo-Puc, Rosa; Góngora-Alfaro, José L.; Álvarez-Cervera, Fernando J.; Pineda, Juan Carlos; Arankowsky‐Sandoval, Gloria; Heredia-López, Francisco J.

doi:10.1016/s0028-3908(03)00202-8

Cited by 48 publications

(28 citation statements)

References 37 publications

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“…4,24 Adenosine receptors are colocalized as heteromers with dopaminergic D2 receptors, inhibiting effects of dopaminergic transmission. 25,26 Numerous animal studies have found motor improvement in toxin-induced models of PD, 27 in dopamine-deficient mice, 28 and in drug-induced parkinsonism 29 with caffeine. Caffeine may also increase bioavailability and prolong the clinical effect of levodopa 30 (note that the clinical effect of caffeine may persist even after levodopa levels decline, suggesting that the D2 receptor interactions are also important).…”

Section: Caffeine and Edsmentioning

confidence: 99%

Caffeine for treatment of Parkinson disease

et al. 2012

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Objective: Epidemiologic studies consistently link caffeine, a nonselective adenosine antagonist, to lower risk of Parkinson disease (PD). However, the symptomatic effects of caffeine in PD have not been adequately evaluated. Methods:We conducted a 6-week randomized controlled trial of caffeine in PD to assess effects upon daytime somnolence, motor severity, and other nonmotor features. Patients with PD with daytime somnolence (Epworth Ͼ10) were given caffeine 100 mg twice daily ϫ3 weeks, then 200 mg twice daily ϫ3 weeks, or matching placebo. The primary outcome was the Epworth Sleepiness Scale score. Secondary outcomes included motor severity, sleep markers, fatigue, depression, and quality of life. Effects of caffeine were analyzed with Bayesian hierarchical models, adjusting for study site, baseline scores, age, and sex.Results: Of 61 patients, 31 were randomized to placebo and 30 to caffeine. On the primary intention-to-treat analysis, caffeine resulted in a nonsignificant reduction in Epworth Sleepiness Scale score (Ϫ1.71 points; 95% confidence interval [CI] Ϫ3.57, 0.13). However, somnolence improved on the Clinical Global Impression of Change (ϩ0.64; 0.16, 1.13, intention-to-treat), with significant reduction in Epworth Sleepiness Scale score on per-protocol analysis (Ϫ1.97; Ϫ3.87, Ϫ0.05). Caffeine reduced the total Unified Parkinson's Disease Rating Scale score (Ϫ4.69 points; Ϫ7.7, Ϫ1.6) and the objective motor component (Ϫ3.15 points; Ϫ5.50, Ϫ0.83).Other than modest improvement in global health measures, there were no changes in quality of life, depression, or sleep quality. Adverse events were comparable in caffeine and placebo groups. Conclusions:Caffeine provided only equivocal borderline improvement in excessive somnolence in PD, but improved objective motor measures. These potential motor benefits suggest that a larger long-term trial of caffeine is warranted.

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Section: Caffeine and Edsmentioning

confidence: 99%

Caffeine for treatment of Parkinson disease

et al. 2012

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“…Catalepsy was measured 1 h after haloperidol or SCH23390 administration in each test session. Two consecutive test sessions were separated by 2 h. Experiments with an acetylcholine (ACh) receptor antagonist were performed as described (Moo-Puc et al, 2003). Atropine (Sigma, 4 mg/kg, i.p.)…”

Section: Animalsmentioning

confidence: 99%

Heart-Type Fatty Acid Binding Protein Regulates Dopamine D₂Receptor Function in Mouse Brain

Shioda¹,

Yamamoto²,

Watanabe³

et al. 2010

J. Neurosci.

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“…Both dopamine and acetylcholine receptors are modulated by adenosine receptors (AdoRs) (Cunha 2001;El Yacoubi et al 2001;Marks et al 2003;Moo-Puc et al 2003;Oliveira & Correia-de-Sa 2005;Salmi et al 2005), which therefore may, hypothetically, be involved in the regulation of eye growth. Nevertheless, the role of AdoRs in form deprivation myopia (FDM) has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Adenosine receptor protein changes in guinea pigs with form deprivation myopia

Cui

Trier²,

Zeng

et al. 2009

Acta Ophthalmologica

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Acta Ophthalmol. 2010: 88: 759–765 Abstract. Purpose: Recent results have shown that treatment with the non‐selective adenosine antagonist 7‐methylxanthine (7‐MX) reduces the development of form deprivation myopia (FDM) in guinea pigs. The aims of this study were to identify the presence of adenosine receptors (AdoRs) in the eye wall of the guinea pig and to determine their possible changes during form deprivation. Methods: Three‐week‐old guinea pigs were monocularly treated with a translucent lens to induce FDM. After 21 days, samples were taken from the posterior eye wall and examined with immunofluorescence confocal microscopy for the presence of AdoRA1, AdoRA2A, AdoRA2B and AdoRA3 proteins. Western blot analysis was used to quantitate AdoRs in samples from the retina, choroids and sclera. Results: All four subtypes of AdoR were expressed in the posterior wall of the guinea pig eye, although AdoRA3 only weakly. Twenty‐one days after the induction of myopia, we observed a significant decrease in protein expression for AdoRA1 (− 25.5%) and an increase in protein expression for AdoRA2B (+ 66.7%) in the retina of FDM eyes. Conclusions: AdoRs of all subtypes are expressed in the retina, choroids and sclera in guinea pigs and may play a role in the regulation of eye growth. The changed pattern of AdoR expression during form deprivation confirms that pharmaceutical intervention targeting AdoRs may reduce myopia progression.

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Caffeine and muscarinic antagonists act in synergy to inhibit haloperidol-induced catalepsy

Cited by 48 publications

References 37 publications

Caffeine for treatment of Parkinson disease

Caffeine for treatment of Parkinson disease

Heart-Type Fatty Acid Binding Protein Regulates Dopamine D₂Receptor Function in Mouse Brain

Adenosine receptor protein changes in guinea pigs with form deprivation myopia

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Caffeine and muscarinic antagonists act in synergy to inhibit haloperidol-induced catalepsy

Cited by 48 publications

References 37 publications

Caffeine for treatment of Parkinson disease

Caffeine for treatment of Parkinson disease

Heart-Type Fatty Acid Binding Protein Regulates Dopamine D2Receptor Function in Mouse Brain

Adenosine receptor protein changes in guinea pigs with form deprivation myopia

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Product

Resources

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Heart-Type Fatty Acid Binding Protein Regulates Dopamine D₂Receptor Function in Mouse Brain