Caffeine Decreases Systemic Urea in Elite Soccer Players during Intermittent Exercise

Bassini, Adriana; Neto, Aníbal Monteiro de Magalhães; Sweet, Eric; Bottino, Altamiro; Veiga, Carlos; Tozzi, Marta B.; Pickard, Megan B.; Cameron, Luiz-Cláudio

doi:10.1249/mss.0b013e3182797637

Cited by 24 publications

(25 citation statements)

References 29 publications

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“…Computation of YYIR2 test global means, SDs and quantiles (Figure 3) involved 116 studies/subgroups reporting on 2,478 participants (median age = 23.2 years, IQR = 20.7–26.0 years) (Young et al, 2005; De Souza et al, 2006; Krustrup et al, 2006; Thomas et al, 2006; Mohr et al, 2007, 2016; Iaia et al, 2008, 2015, 2017; Morton et al, 2009; Rampinini et al, 2010; Rebelo et al, 2010; Thomassen et al, 2010; Christensen et al, 2011; Chuman et al, 2011; Mooney et al, 2011, 2013a,b; Roberts et al, 2011; Ueda et al, 2011; Gunnarsson et al, 2012; Ingebrigtsen et al, 2012, 2013, 2014; Nakamura et al, 2012; Saunders et al, 2012; Wells et al, 2012, 2014; Bassini et al, 2013; Buchheit et al, 2013; McGawley and Andersson, 2013; Mohr and Krustrup, 2013, 2014, 2016; Owen et al, 2013; Pivovarniček et al, 2013; Yuki et al, 2013; Fanchini et al, 2014; Karavelioglu et al, 2014; Lollo et al, 2014; Miloski et al, 2014; Nunes et al, 2014; Sampaio et al, 2014; Skovgaard et al, 2014; Brocherie et al, 2015a,b; Cholewa et al, 2015; Coelho et al, 2015; Gatterer et al, 2015; Hogarth et al, 2015a,b; Jamurtas et al, 2015; Krustrup and Mohr, 2015; Leme et al, 2015; Mara et al, 2015; Matta et al, 2015; McLean et al, 2015; Michalsik et al, 2015; Mohr, 2015; Rogan, 2015; Stein et al, 2015; Boer and Van Aswegen, 2016; Bouaziz et al, 2016; Chan et al, 2016; Inness et al, 2016; Joo, 2016; Kilit and Arslan, 2016; Lockie et al, 2016a,b,...…”

Section: Resultsmentioning

confidence: 99%

The Yo-Yo Intermittent Tests: A Systematic Review and Structured Compendium of Test Results

Schmitz¹,

Pfeifer²,

Kreitz³

et al. 2018

Front. Physiol.

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Background: Although Yo-Yo intermittent tests are frequently used in a variety of sports and research studies to determine physical fitness, no structured reference exists for comparison and rating of test results. This systematic review of the most common Yo-Yo tests aimed to provide reference values for test results by statistical aggregation of published data.Methods: A systematic literature search for articles published until August 2017 was performed in MEDLINE, Web of Science, SPORTDiscus and Google Scholar. Original reports on healthy females and males ≥16 years were eligible for the analysis. Sub-maximal test versions and the Yo-Yo Intermittent Recovery Level 1 Children's test (YYIR1C) were not included.Results: 248 studies with 9,440 participants were included in the structured analysis. The Yo-Yo test types most frequently used were the Yo-Yo Intermittent Recovery Level 1 (YYIR1, 57.7%), the Yo-Yo Intermittent Recovery Level 2 (YYIR2, 28.0%), the Yo-Yo Intermittent Endurance Level 2 (YYIE2, 11.4%), and the Yo-Yo Intermittent Endurance Level 1 (YYIE1, 2.9%) test. For each separate test, reference values (global means and percentiles) for sports at different levels and both genders were calculated.Conclusions: Our analysis provides evidence that Yo-Yo intermittent tests reference values differ with respect to the type and level of sport performed.The presented results may be used by practitioners, trainers and athletes to rate Yo-Yo intermittent test performance levels and monitor training effects.

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Section: Resultsmentioning

confidence: 99%

The Yo-Yo Intermittent Tests: A Systematic Review and Structured Compendium of Test Results

Schmitz¹,

Pfeifer²,

Kreitz³

et al. 2018

Front. Physiol.

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“…In the individual analysis of the studies there was no response of caffeine. According to the hypothesis of Bassini et al 16 , the hyperammonic state changes the function of the blood-brain barrier and is postulated to cause central fatigue during exercise. However, we observed that the maximum running distance was small to induce hyperammonemia in athletes and consequently it was also small to test the positive ergogenic effect of caffeine.…”

Section: Discussionmentioning

confidence: 99%

“…Effect of caffeine intake on maximum running distance Two of the studies applied the yo-yo test (i.e., field test designed to estimate the maximum oxygen uptake -VO2max and the maximum running distance by athletes) to assess the maximum running distance of the subjects. The authors used caffeine dosage of 5 mg/kg of body weight 16 and 6 mg/kg of body weight 17 and found no improvement in the maximum running distance of the subjects (effect size = 0.37, p= 0.14, interpretation: small; Figure 3). The I2 statistic showed minimal heterogeneity between the studies (I2= 0.00; p= 0.55).…”

Section: Description Of the Included Studiesmentioning

confidence: 97%

Acute effects of caffeine intake on athletic performance: A systematic review and meta-analysis

et al. 2017

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“…However, ALT and ALP elevation are also observed in non-liver-injury conditions and in apparently healthy athletes 25,26 . γGT is an abundant enzyme in the liver, and abnormal γGT levels can be used to diagnose various diseases.…”

Section: Discussionmentioning

confidence: 99%

“…γGT is an abundant enzyme in the liver, and abnormal γGT levels can be used to diagnose various diseases. In exercise biochemistry, γGT is used as a speci ic marker of liver injury to differentiate the location of damage 23,25,27 . Although we cannot ignore the reported in luence of endurance training on chronic liver injury 9,11,28 , we believe that the hepatotoxic effect of APAP was responsible in this case.…”

Section: Discussionmentioning

confidence: 99%

A sportomic follow-up of a muscle injury succeeded by acetaminophen hepatotoxicity

Magno-França¹,

Bassini²,

Bessa³

et al. 2013

OA Sports Medicine

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IntroductionThe aim of this study is to communicate the diagnosis followed by a successful treatment and rapid evolution from a silent liver injury due to the use of self-medication with large doses of acetaminophen, without a stop in training or a loss of performance. Materials and methodsWe measured the VO 2max and analysed a sportomic pro ile of four national elite cyclists and diagnosed a liver injury caused by pharmaceutical abuse in one athlete. We suggested that the injured athlete decrease both training intensity and volume by 30% to 40% while simultaneously increasing resting and sleeping time. We discontinued the use of acetaminophen and started a high intake of dietary methionine and cysteine together with N-acetyl-cysteine daily. Results After 2 weeks of following our regimen and dietary recommendations, the athlete reported pain relief. This change was corroborated by biochemical analysis, which showed that the amounts of creatine kinase and gammaglutamyltransferase in blood were less than 20% and 70% of pre-treatment levels, respectively. As a referral of our treatment, the team won third place in an 800-km cycling competition. ConclusionThis study has shown that collecting and analysing physiological data during training can give important information about an athlete's clinical condition as well as the degree of performance. In this particular case, we have shown that 2 weeks of reduced training, combined with dietary changes, can promote liver recovery. The importance of this report is that we were able to diagnose and treat a silent liver injury and maintain an athlete's performance during both training and competition.

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Caffeine Decreases Systemic Urea in Elite Soccer Players during Intermittent Exercise

Abstract: Our data suggest that caffeine might decrease systemic urea by decreasing the glutamine serum concentration, which decreases the transportation of ammonia to the liver and thus urea synthesis.

Cited by 24 publications

References 29 publications

The Yo-Yo Intermittent Tests: A Systematic Review and Structured Compendium of Test Results

The Yo-Yo Intermittent Tests: A Systematic Review and Structured Compendium of Test Results

Acute effects of caffeine intake on athletic performance: A systematic review and meta-analysis

A sportomic follow-up of a muscle injury succeeded by acetaminophen hepatotoxicity

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