Caffeine-induced psychiatric manifestations

Wang, Hee Ryung; Woo, Young Sup; Bahk, Won‐Myong

doi:10.1097/yic.0000000000000076

Cited by 39 publications

(24 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For some psychiatric illness, such as Parkinson’s disease, Alzheimer’s disease, and depression, caffeine antagonism of adenosine receptors may improve symptoms (204, 205) and slow the progression of neurodegeneration (206, 207), although these findings are equivocal with some studies reporting caffeine increases depressive symptoms (208). For other mental illness, such as schizophrenia, caffeine may exacerbate psychotic symptoms (209), although the majority of this literature is informed by case studies, with very few double-blind placebo-controlled studies (210). There is also good evidence that higher caffeine use is associated with greater reporting of anxiety symptoms (211, 212) and may increase risk of symptom relapse (213) and suicide among bipolar disorder patients (214).…”

Section: Populations At-risk For Harmful Effects Of Caffeinementioning

confidence: 99%

The Safety of Ingested Caffeine: A Comprehensive Review

Temple¹,

Bernard²,

Lipshultz³

et al. 2017

Front. Psychiatry

382

254

View full text Add to dashboard Cite

Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to promote arousal, alertness, energy, and elevated mood. Over the past decade, the introduction of new caffeine-containing food products, as well as changes in consumption patterns of the more traditional sources of caffeine, has increased scrutiny by health authorities and regulatory bodies about the overall consumption of caffeine and its potential cumulative effects on behavior and physiology. Of particular concern is the rate of caffeine intake among populations potentially vulnerable to the negative effects of caffeine consumption: pregnant and lactating women, children and adolescents, young adults, and people with underlying heart or other health conditions, such as mental illness. Here, we review the research into the safety and safe doses of ingested caffeine in healthy and in vulnerable populations. We report that, for healthy adults, caffeine consumption is relatively safe, but that for some vulnerable populations, caffeine consumption could be harmful, including impairments in cardiovascular function, sleep, and substance use. We also identified several gaps in the literature on which we based recommendations for the future of caffeine research.

show abstract

Section: Populations At-risk For Harmful Effects Of Caffeinementioning

confidence: 99%

The Safety of Ingested Caffeine: A Comprehensive Review

Temple¹,

Bernard²,

Lipshultz³

et al. 2017

Front. Psychiatry

382

254

View full text Add to dashboard Cite

show abstract

“…Tobacco smoking is highly prevalent among SCZ and bipolar patients (51) and has been associated with worse outcomes and lower remission rates in BPD (49, 52). In addition, there have been case reports of psychiatric relapse following excessive caffeine consumption in patients suffering from SCZ (53) and BPD (54). …”

Section: Introductionmentioning

confidence: 99%

Utility of Washington Early Recognition Center Self-Report Screening Questionnaires in the Assessment of Patients with Schizophrenia and Bipolar Disorder

2016

View full text Add to dashboard Cite

Early identification and treatment are associated with improved outcomes in bipolar disorder (BPD) and schizophrenia (SCZ). Screening for the presence of these disorders usually involves time-intensive interviews that may not be practical in settings where mental health providers are limited. Thus, individuals at earlier stages of illness are often not identified. The Washington Early Recognition Center Affectivity and Psychosis (WERCAP) screen is a self-report questionnaire originally developed to identify clinical risk for developing bipolar or psychotic disorders. The goal of the current study was to investigate the utility of the WERCAP Screen and two complementary questionnaires, the WERC Stress Screen and the WERC Substance Screen, in identifying individuals with established SCZ or BPD. Participants consisted of 35 BPD and 34 SCZ patients, as well as 32 controls (CON), aged 18–30 years. Univariate analyses were used to test for score differences between groups. Logistic regression and receiver operating characteristic (ROC) curves were used to identify diagnostic predictors. Significant group differences were found for the psychosis section of the WERCAP (pWERCAP; p < 0.001), affective section of the WERCAP (aWERCAP; p = 0.001), and stress severity (p = 0.027). No significant group differences were found in the rates of substance use as measured by the WERC Substance Screen (p = 0.267). Only the aWERCAP and pWERCAP scores were useful predictors of diagnostic category. ROC curve analysis showed the optimal cut point on the aWERCAP to identify BPD among our participant groups was a score of >20 [area under the curve (AUC): 0.87; sensitivity: 0.91; specificity: 0.71], while that for the pWERCAP to identify SCZ was a score of >13 (AUC: 0.89; sensitivity: 0.88; specificity: 0.82). These results indicate that the WERCAP Screen may be useful in screening individuals for BPD and SCZ and that identifying stress and substance-use severity can be rapidly done using self-report questionnaires. Larger studies in undiagnosed individuals will be needed to test the WERCAP Screen’s ability to identify mania or psychosis in the community.

show abstract

“…In line with this, administration of a selective A 2A R agonist effectively antagonized phencyclidine (PCP)-induced locomotor activity in rats [18], an animal model of schizophrenic symptomatology [19]. Similarly, the non-selective adenosine receptor antagonist caffeine has been described to exacerbate psychosis in schizophrenic patients [20].…”

Section: Introductionmentioning

confidence: 82%

Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia

Valle-León

Callado

Aso

et al. 2020

Neuropsychopharmacol.

View full text Add to dashboard Cite

According to the adenosine hypothesis of schizophrenia, the classically associated hyperdopaminergic state may be secondary to a loss of function of the adenosinergic system. Such a hypoadenosinergic state might either be due to a reduction of the extracellular levels of adenosine or alterations in the density of adenosine A 2A receptors (A 2A Rs) or their degree of functional heteromerization with dopamine D 2 receptors (D 2 R). In the present study, we provide preclinical and clinical evidences for this latter mechanism. Two animal models for the study of schizophrenia endophenotypes, namely the phencyclidine (PCP) mouse model and the A 2A R knockout mice, were used to establish correlations between behavioral and molecular studies. In addition, a new AlphaLISA-based method was implemented to detect native A 2A R-D 2 R heteromers in mouse and human brain. First, we observed a reduction of prepulse inhibition in A 2A R knockout mice, similar to that observed in the PCP animal model of sensory gating impairment of schizophrenia, as well as a significant upregulation of striatal D 2 R without changes in A 2A R expression in PCP-treated animals. In addition, PCP-treated animals showed a significant reduction of striatal A 2A R-D 2 R heteromers, as demonstrated by the AlphaLISA-based method. A significant and pronounced reduction of A 2A R-D 2 R heteromers was next demonstrated in post-mortem caudate nucleus from schizophrenic subjects, even though both D 2 R and A 2A R were upregulated. Finally, in PCP-treated animals, sub-chronic administration of haloperidol or clozapine counteracted the reduction of striatal A 2A R-D 2 R heteromers. The degree of A 2A R-D 2 R heteromer formation in schizophrenia might constitute a hallmark of the illness which indeed should be further studied to stablish possible correlations with chronic antipsychotic treatments.

show abstract

Caffeine-induced psychiatric manifestations

Cited by 39 publications

References 18 publications

The Safety of Ingested Caffeine: A Comprehensive Review

The Safety of Ingested Caffeine: A Comprehensive Review

Utility of Washington Early Recognition Center Self-Report Screening Questionnaires in the Assessment of Patients with Schizophrenia and Bipolar Disorder

Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia

Contact Info

Product

Resources

About