Caffeine influences cadence at lower but not higher intensity RPE-regulated cycling

Green, J. Matt; Olenick, Alyssa A.; Eastep, Caroline; Winchester, Lee J.

doi:10.1016/j.physbeh.2016.11.007

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…Compared to the literature, our ndings appear to be in agreement with those studies indicating that endurance indices such as VO2max (30)(31)(32)(33)(34)(35) 33). A meta-analysis also suggested that TTE was increased following caffeine ingestion compared to placebo, yet a dose-response relationship failed to materialize (41).…”

Section: Discussionsupporting

confidence: 90%

“…Although numerous investigations have shown improvement in RPE after caffeine consumption (40,50), the lack of any signi cant RPE alterations in the present study may be explained in several ways. For example, unlike physiological outcomes, differences in individual psychological responses may show greater variability and help to explain such rather unexpected ndings (30). Further, any caffeine effects on RPE may also be affected by the type and intensity of exercise.…”

Section: Discussionmentioning

confidence: 99%

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Low-dose caffeine consumption is a valuable strategy for increasing time to exhaustion, explosive power, and reducing muscle soreness in professional male kickboxers

Saremi,

Shahriari,

Hemmatinafar

et al. 2024

Preprint

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Purpose: This study aimed to evaluate the effects of acute caffeine supplementation of varied doses on kickboxing athletes' performance indices and perceived muscle pain. Methods: Twelve kickboxing athletes participated in 3 exercise sessions and caffeine supplementation comprising doses of 3 mg/kg (C3), 6 mg/kg (C6), or 3- placebo (PLA) with a one-week wash-out period between exercise trials. The supplement was taken 60 minutes before each exercise session. In each session, the subjects first performed the vertical jump, Wingate anaerobic test and after a 45-minute break, performed the Bruce maximal aerobic test and the maximal oxygen consumption (VO2max), oxygen consumption equivalent to ventilation threshold (VT2), Time-to-exhaustion (TTE), Rating of Perceived Exertion (RPE), relative peak power (RPP), relative mean power (RMP), relative lowest power (RLP) and the Wingite Fatigue Index (WFI) after Bruce test were examined. Results: Consumption of C3 or C6 significantly increased the TTE following treadmill testing (p<0.05), but had no effect on the WFI (p> 0.05). Compared to PLA, the consumption of C3 and C6 significantly increased vertical jump (p<0.05). C3 significantly increases the RPP (p <0.05), whereas C6 did not (p> 0.05) during the Wingate Test. Muscle soreness after two hours (Ms2) showed a significant decrease after C6 supplementation compared to C3 and PLA (p<0.05). In contrast, no significant effect was observed on the VO2max, %VO2max at ventilatory threshold 2, and RPE (p>0.05). Conclusion: In conclusion, acute consumption of low to moderate doses of caffeine induces relative improvements in anaerobic and lower-body muscular power, muscle soreness, and TTE in male kickboxing athletes.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Low-dose caffeine consumption is a valuable strategy for increasing time to exhaustion, explosive power, and reducing muscle soreness in professional male kickboxers

Saremi,

Shahriari,

Hemmatinafar

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…The ergogenic effects of caffeine have been demonstrated in different sport modalities, namely running [8,9], cycling [10,11], rowing [12], track and field [3], team sports [4], and martial arts [13], among others.…”

mentioning

confidence: 99%

Potential pitfalls when investigating the ergogenic effects of caffeine in mice

Solano¹,

Scheffer²,

Alves³

et al. 2017

J Syst Integr Neurosci

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Caffeine (1,3,7-trimethylxantine) is the most commonly consumed social drug in western society for increased physical and cognitive performance [1][2][3][4][5], and it is the main ergogenic resource used by athletes [6]. Initially controversial, caffeine was banned by the International Olympic Committee from 1980-2003 [1,6,7], but then in 2004 its use was approved by the World Anti-doping Agency (WADA), and later this year by the U.S. Anti-doping Agency (USADA; 2016). However, caffeine has remained on the lists of monitored substances of these anti-doping agencies. Caffeine is rapidly and completely absorbed by the gastrointestinal tract and is readily distributed throughout all tissues of the body, including muscles and the central nervous system (CNS), which are believed to be the main recipients of caffeine's ergogenic effects [2,14]. Ergogenic doses of caffeine ranging from 3 to 9 mg/kg body mass [6] appear to have no adverse effects. A moderate oral dose of 6 mg/ kg body mass, which elicits peak plasma levels of about 60 µmol/L concentrations after 30 to 60 min, with half-life for elimination range between 2.5-10 h, is known to enhance physical and cognitive performance [5,6,10,14,15]. Blood levels of 1 -2 mmol/L are known to be toxic and even lethal [14], and have been associated with suicides [16]. Caffeine's molecular mechanisms for increasing physical performance are still virtually undefined. However, due to its ability to cross the blood-brain barrier at blood concentrations generated by a moderate ergogenic dose, and because of its properties as a stimulant psychotropic drug [15,17], mechanisms involving metabolic and central effects have been proposed.Metabolic effects of caffeine have been mainly related to the enhancement of lipolysis, fatty acid oxidation and energy expenditure via the stimulation of the sympathetic nervous system [18,19] and a sequential sparing of muscle glycogen [20]. However, the main pharmacological effects of caffeine appear to be mediated via the CNS where caffeine counterbalances the inhibitory neuromodulation of adenosine in order to induce effects on both the CNS and peripheral nervous system to reduce pain and exertion perception [21], to improve motor recruitment [22] and to increase excitation-contraction coupling [23,24].Caffeine is a non-selective competitive adenosine receptor antagonist (A 1 R and A 2 AR subtypes) that increases neurotransmission via dopamine D 2 receptors (D 2 R) [25,26]. The striatum expresses high levels of A 2 AR where they are co-expressed with postsynaptic D 2 R, forming A 2 AR-D 2 R heterodimers [25]. In this scenario, caffeine fails to be ergogenic in the mouse lacking A 2 AR [27], or in wild type rats treated with the selective A 2 AR agonist 5'-N-ethylcarboxamidoadenosine (NECA) [26], which denotes the participation of these receptors in caffeine's central-mediated ergogenic effects.When designing experimental models to better define the molecular mechanisms involved in the enhanced capacity of caffeine to positively modulate physical ...

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“…Third, pedal cadence was kept within a range (i.e., between 70 and 80 revolutions per minute); thus, small changes within this range induced by CAF ingestion could affect performance fatigability. However, CAF seems to have minimal influence (~1 revolution per minute) on pedal cadence during high-intensity exercise (62), which probably is insufficient to affect our results. Fourth, the use of doublet pulse reduces the signal to noise ratio during VA determination (63,64).…”

Section: Discussionmentioning

confidence: 71%

Caffeine Increases Endurance Performance via Changes in Neural and Muscular Determinants of Performance Fatigability

Cristina-Souza

Santos

Santos-Mariano

et al. 2022

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose: In the present study, we tested the hypothesis that caffeine would increase endurance performance via attenuation of neural and muscular determinants of performance fatigability during high-intensity, whole-body exercise. Methods: Ten healthy males cycled until exhaustion (89% ± 2% of VO 2max ) after the ingestion of caffeine or placebo. During another four visits, the same exercise was performed after either caffeine or placebo ingestion but with exercise discontinued after completing either 50% or 75% of the duration of placebo trial. An additional trial with caffeine ingestion was also performed with interruption at the placebo time to exhaustion (isotime). Performance fatigability was measured via changes in maximal voluntary contraction, whereas neural and muscular determinants of performance fatigability were quantified via preexercise to postexercise decrease in quadriceps voluntary activation (VA) and potentiated twitch force, respectively. Results: Compared with the placebo, caffeine increased time to exhaustion (+14.4 ± 1.6%, P = 0.017, 314.4 ± 47.9 vs 354.9 ± 40.8 s). Caffeine did not change the rate of decline in maximal voluntary contraction (P = 0.209), but caffeine reduced the twitch force decline at isotime when stimulating at single twitch (−58.6 ± 22.4 vs À45.7 ± 21.9%, P = 0.014) and paired 10 Hz electrical stimuli (−37.3 ± 13.2 vs À28.2 ± 12.9%, P = 0.025), and reduced the amplitude of electromyography signal during cycling at isotime (P = 0.034). The decline in VA throughout the trial was lower (P = 0.004) with caffeine (−0.5 ± 4.2%) than with placebo (−5.8 ± 8.5%). Caffeine also maintained peripheral oxygen saturation at higher levels (95.0 ± 1.9%) than placebo (92.0 ± 6.2%, P = 0.016). Conclusions: Caffeine ingestion improves performance during high-intensity, whole-body exercise via attenuation of exercise-induced reduction in VA and contractile function.

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Caffeine influences cadence at lower but not higher intensity RPE-regulated cycling

Cited by 9 publications

References 12 publications

Low-dose caffeine consumption is a valuable strategy for increasing time to exhaustion, explosive power, and reducing muscle soreness in professional male kickboxers

Low-dose caffeine consumption is a valuable strategy for increasing time to exhaustion, explosive power, and reducing muscle soreness in professional male kickboxers

Potential pitfalls when investigating the ergogenic effects of caffeine in mice

Caffeine Increases Endurance Performance via Changes in Neural and Muscular Determinants of Performance Fatigability

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