Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose–response meta-analysis

Greenwood, Darren C.; Thatcher, Natalie J; Jin, Ye; Garrard, Lucy; Keogh, Georgina; King, Laura G.; Cade, Janet

doi:10.1007/s10654-014-9944-x

Cited by 122 publications

(107 citation statements)

References 55 publications

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“…The results of recent meta-analyses also indicate that higher maternal coffee consumption may increase the risk of low birth weight in offspring (18,73) . Currently, the WHO recommends a caffeine intake of less than 300 mg (~3 cups of coffee) per day.…”

Section: Discussionmentioning

confidence: 99%

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Chen

Neelakantan

et al. 2015

Public Health Nutr.

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Objective: To assess the association between maternal caffeine intake and risk of pregnancy loss using a systematic review and meta-analysis. Design: Categorical and dose-response meta-analysis of prospective studies. Setting: Relevant articles were identified by searching MEDLINE and SCOPUS databases through 30 January 2015. Two authors independently extracted information from eligible studies. Random-effects models were used to derive the summary relative risks (RR) and corresponding 95 % CI for specific categories of caffeine consumption and for a continuous association using generalized leastsquares trend estimation. Subjects: A total of 130 456 participants and 3429 cases in fourteen included studies. Results: Compared with the reference category with no or very low caffeine intake, the RR (95 % CI) of pregnancy loss was 1·02 (0·85, 1·24; I 2 = 28·3 %) for low intake (50-149 mg/d), 1·16 (0·94, 1·41; I 2 = 49·6 %) for moderate intake (150-349 mg/d), 1·40 (1·16, 1·68; I 2 = 18·6 %) for high intake (350-699 mg/d) and 1·72 (1·40, 2·13; I 2 = 0·0 %) for very high intake (≥700 mg/d). In the dose-response analysis, each 100 mg/d increment in maternal caffeine intake (~1 cup of coffee) was associated with 7 % (95 % CI 3 %, 12 %) higher risk of pregnancy loss. Our results may have been affected by publication bias, but the association remained significant for the subset of larger studies. Furthermore, adjustment for smoking and pregnancy symptoms may have been incomplete, potentially resulting in residual confounding. Conclusions: Albeit inconclusive, higher maternal caffeine intake was associated with a higher risk of pregnancy loss and adherence to guidelines to avoid high caffeine intake during pregnancy appears prudent.

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Section: Discussionmentioning

confidence: 99%

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Chen

Neelakantan

et al. 2015

Public Health Nutr.

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“…Further, caffeine intake in women prior to pregnancy has not been conclusively shown to affect fertility; however, it may increase their risk for spontaneous abortion in the first trimester (29)(30)(31). Even though there is conflicting evidence in the literature about the effects of substance use and fertility, it is recommended that men and women cease use of these substances for fertility, preconception health, and overall good health (6,17,18,21,23,24,32).…”

Section: Effects Of Substance Use On Reproductive Healthmentioning

confidence: 99%

Substance Use and Preconception Care: A Review of the Literature

Ricks¹,

Comer²,

Liu³

et al. 2017

IJWHR

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“…Recent dose-response meta-analyses examining the association between prenatal caffeine exposure and risk of adverse pregnancy outcomes indicate that greater caffeine intake during pregnancy may be associated with an increased risk of SA, low birth weight, and small-for-gestational-age infants, but not preterm birth (16,17).…”

Section: Introductionmentioning

confidence: 99%

Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study

et al. 2017

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Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose–response meta-analysis

Abstract: Background: Caffeine is commonly consumed during pregnancy, crosses the placenta, with fetal serum concentrations similar to the mother's, but studies of birth outcome show

Cited by 122 publications

References 55 publications

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Substance Use and Preconception Care: A Review of the Literature

Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study

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