Caffeine may enhance orthodontic tooth movement through increasing osteoclastogenesis induced by periodontal ligament cells under compression

Yi, Jianru; Yan, Bowei; Li, Meile; Wang, Yu; Zheng, Wei; Yu, Li; Zhao, Zhihe

doi:10.1016/j.archoralbio.2015.12.009

Cited by 37 publications

(32 citation statements)

References 42 publications

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“…The increasing distal movement of mandibular incisors is caused by caffeine generating osteoclastogenesis through an increase in RANKL. 24,25 The results of this research are in accordance with those of several previous investigations which posited that a low dose of caffeine can elevate osteoclasts and bone resorption on the pressure side of alveolar bone on Day 14. 11 Research conducted by Yamaguchi (2009), indicated that RANKL expression increases significantly followed by bone resorption caused by orthodontic tooth movement on day 21.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of orthodontic tooth movement by 3D micro-computed tomography (µ-CT) following caffeine administration

et al. 2019

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Background: The compressive strength of orthodontic tooth movement will be distributed throughout the periodontal ligament and alveolar bone, resulting in bone resorption on the pressure side and new bone formation on the tension side. Caffeine, a member of the methyl xanthine family, represents a widely-consumed psychoactive substance that can stimulate osteoclastogenesis through an increase in RANKL. A 3D Micro-Computed Tomography (µ-CT) x-ray device can be used to measure orthodontic tooth movement and changes in periodontal ligament width. Purpose: The purpose of this research was to analyze the effects of caffeine on the distal movement distance of two mandibular incisors using 3D µ-CT. Methods: The research subjects (guinea pigs) were randomly divided into four groups. Of the two control groups created, one received two weeks of treatment and the other three weeks. The members of these two control groups were subjected to orthodontic movement but received no caffeine. Meanwhile, the other two groups were treatment groups whose members also received either two or three weeks of treatment. In these two treatment groups, the subjects were subjected to orthodontic movement and received a 6 mg/500 BM dose of caffeine. The orthodontic movement of the subjects was induced by installing a band matrix and orthodontic bracket on each mandibular incisor to move distally by means of an open coil spring. Observations were then conducted on days 15 and 22 with µ-CT x-rays to measure the distal movement distance of the two mandibular incisors and the width of the periodontal ligament. Results: The administration of caffeine increased the tooth movement on day 15 (p<0.05) and day 22 (p<0.05). The increase in the tooth movement on day 22 was greater than that on day 15 (p<0.05). The width of the periodontal ligament on the pressure side of the treatment groups experienced greater narrowing than that of the control groups (p<0.05). Meanwhile, the width of periodontal ligament on the tension side of the treatment groups widened more than that of the control groups (p<0.05). Conclusion: µ-CT x-ray can be used to evaluate the extent of orthodontic movement in addition to the width of the mandibular incisor periodontal ligament during orthodontic tooth movement. Moreover, it has been established that the administering of caffeine can improve orthodontic tooth movement.

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Section: Discussionsupporting

confidence: 91%

Evaluation of orthodontic tooth movement by 3D micro-computed tomography (µ-CT) following caffeine administration

et al. 2019

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“…Previous research also shows that caffeine can improve an osteoclastogenic ability of periodontal ligament cells under stress, and increase tooth movement through PGE2-RANKL. 16 Thus, a decrease in OPG expression may probably be caused by an increase in proinflamatory cytokine triggered by orthodontic pressure, will inhibit OPG expression. 6 Results of this research also indicated the increased levels of RANKL at the pressure sites after the administration of coffee brew was larger than at the tension sites, especially on day 22.…”

Section: Discussionmentioning

confidence: 99%

“…15 Caffeine increases osteoclastogenesis by improving RANKL. 16 Caffeic acid has antioxidant effects that can reduce oxidative stress on osteoblasts. 17 Another research also illustrates that chlorogenic acid promotes osteogenesis on human adipose tissue derived from mesenchymal stem cells (hAMSCs), indicated by an increase in bone mineralization.…”

Section: Introductionmentioning

confidence: 99%

Effects of Robusta coffee (Coffea canephora) brewing on levels of RANKL and TGF- β1 in orthodontic tooth movement

Herniyati

Narmada

Soetjipto

2016

Dent. J. (Majalah Kedokteran Gigi)

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“…In PDLCs, 65 g/cm 2 (245 kPa) static compression given by weight could take part in the initiation of osteoclastogenesis. It could upregulate the expression of pro-osteoclastogenic cytokine, like receptor activator for nuclear factor-κB ligand (RANKL) and parathyroid hormone-related protein (PTHrP), and the pro-inflammation cytokines including IL-8 and IL-11 [10,11]. It has been demonstrated that 150 psi (1034 kPa) static compression by air pressure could up-regulate the expressions of matrix metalloproteinases (MMPs)-1/7/9, which are the cytokines regulating the degradation of extracellular matrix, and inflammation-related genes in inflammatory hPDLCs [12].…”

Section: Introductionmentioning

confidence: 99%

Cyclic compression emerged dual effects on the osteogenic and osteoclastic status of LPS-induced inflammatory human periodontal ligament cells according to loading force

Jia

Liu

et al. 2020

BMC Oral Health

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Background: Appropriate mechanical stimulation is essential for bone homeostasis in healthy periodontal tissues. While the osteogenesis and osteoclast differentiation of inflammatory periodontal ligament cells under different dynamic loading has not been yet clear. The aim of this study is to clarify the inflammatory, osteogenic and proosteoclastic effects of different cyclic stress loading on the inflammatory human periodontal ligament cells (hPDLCs). Methods: hPDLCs were isolated from healthy premolars and cultured in alpha minimum Eagle's medium (α-MEM). Lipopolysaccharides (LPS) were used to induce the inflammation state of hPDLCs in vitro. Determination of LPS concentration for the model of inflammatory periodontium was based on MTT and genes expression analysis. Then the cyclic stress of 0, 0-50, 0-90 and 0-150 kPa was applied to the inflammatory hPDLCs for 5 days respectively. mRNA and protein levels of osteogenic, osteoclastic and inflammation-related markers were examined after the treatment. Results: MTT and RT-PCR results showed that 10 μg/ml LPS up-regulated TNF-α, IL-1β, IL-6, IL-8 and MCP-1 mRNA levels (P < 0.05) and did not affect the cell viability (P > 0.05). The excessive loading of stress (150 kPa) with or without LPS strongly increased the expression of inflammatory-related markers TNF-α, IL-1β, IL-6, IL-8, MCP-1 (P < 0.05) and osteoclastic markers RANKL, M-CSF, PTHLH and CTSK compared with other groups (P < 0.05), but had no significant effect on osteogenic genes. While 0-90 kPa cyclic pressure could up-regulate the expression of osteogenic genes ALP, COL-1, RUNX2, OCN, OPN and OSX in the healthy hPDLSCs. Conclusions: Collectively, it could be concluded that 0-150 kPa was an excessive stress loading which accelerated both inflammatory and osteoclastic effects, while 0-90 kPa may be a positive factor for the osteogenic differentiation of hPDLCs in vitro.

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Caffeine may enhance orthodontic tooth movement through increasing osteoclastogenesis induced by periodontal ligament cells under compression

Cited by 37 publications

References 42 publications

Evaluation of orthodontic tooth movement by 3D micro-computed tomography (µ-CT) following caffeine administration

Evaluation of orthodontic tooth movement by 3D micro-computed tomography (µ-CT) following caffeine administration

Effects of Robusta coffee (Coffea canephora) brewing on levels of RANKL and TGF- β1 in orthodontic tooth movement

Cyclic compression emerged dual effects on the osteogenic and osteoclastic status of LPS-induced inflammatory human periodontal ligament cells according to loading force

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