Cajachalcone: An Antimalarial Compound from<i>Cajanus cajan</i>Leaf Extract

Ajaiyeoba, E. O.; Ogbole, Omonike O.; Abiodun, Olufunmilola Adunni; Ashidi, J. S.; Houghton, Peter J.; Wright, Colin W.

doi:10.1155/2013/703781

Cited by 31 publications

(13 citation statements)

References 23 publications

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“…From the methanol extract of the leaves of this plant, 2,6-dihydroxy-4-methoxy chalcone (89), a cajachalcone, was isolated through bioassay-guided fractionation, which used the parasite lactate dehydrogenase assay by targeting the K1 strain of P. falciparum ( Figure 17). The cajachalcone showed an IC50 value of 7.4 μM [48]. …”

Section: Fabaceae Familymentioning

confidence: 98%

Antimalarial Activity of Plant Metabolites

Pan¹,

Xu²,

Shi³

et al. 2018

Preprint

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in the developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2,000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to identification of several potent antimalarial compounds. The prior comprehensive review article entitled "Antimalarial activity of plant metabolites" by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literatures from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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Section: Fabaceae Familymentioning

confidence: 98%

Antimalarial Activity of Plant Metabolites

Pan¹,

Xu²,

Shi³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…From the methanol extract of the leaves of this plant, 2′,6′-dihydroxy-4-methoxy chalcone ( 89 ), a cajachalcone, was isolated through bioassay-guided fractionation, which used the parasite lactate dehydrogenase assay by targeting the K1 strain of P. falciparum ( Figure 17 ). The cajachalcone showed an IC 50 value of 7.4 μM [ 47 ].…”

Section: Plant-derived Antimalarial Compoundsmentioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan

Shi

et al. 2018

IJMS

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to the identification of several potent antimalarial compounds. The prior comprehensive review article entitled “Antimalarial activity of plant metabolites” by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literature from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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“…Severe fungal diseases result from other health challenges such as human immunodeficiency virus (HIV), asthma, cancer, organ transplantation, and corticosteroid treatments [ 80 ]. In Nigeria, fungal infections (cryptococcal antigenemia, subclinical histoplasmosis) have been implicated in HIV/AIDS patients and neonatal intensive care babies [ 81 , 82 ]. In Cameroun, esophageal candidiasis, cryptococcal meningitis, Pneumocystis pneumonia, disseminated histoplasmosis, and invasive aspergillosis were prevalent in adults, while tinea capitis was prevalent among school children ([ 83 ].…”

Section: Medicinal Plants In Nigeria With Antimicrobial Activitiesmentioning

confidence: 99%

Antimicrobial Importance of Medicinal Plants in Nigeria

Ugboko

Nwinyi

Oranusi

et al. 2020

The Scientific World Journal

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Despite the success of antibiotic discovery, infectious diseases remain the second leading source of death worldwide, while the resistance to antibiotics is among the significant problems in the twenty-first century. Medicinal plants are very rich in phytochemicals which can be structurally optimized and processed into new drugs. Nigeria enjoys a diverse collection of medicinal plants, and joint research has ascertained the efficacy of these plants. Plants such as guava (Psidium guajava), ginger (Zingiber officinale), neem (Azadirachta indica), and moringa (Moringa oleifera) have been found to exhibit broad range of antimicrobial activities. Studies on Nigerian plants have shown that they contain alkaloids, polyphenols, terpenes, glycosides, and others with possible therapeutic potentials. The antimicrobial activities of some new compounds such as alloeudesmenol, hanocokinoside, orosunol, and 8-demethylorosunol, identified from medicinal plants in Nigeria, are not yet explored. Further investigation and optimization of these compounds will facilitate the development of new sets of pharmacologically acceptable antimicrobial agents. This review study revealed the efficacy of medicinal plants as an alternative therapy in combating and curtailing the development and survival of multidrug-resistant pathogens coupled with the toxic effects of some antibiotics. Due to enormous therapeutic possibilities buried in medicinal plants, there is a need for more research into unique fingerprints and novel compounds that can provide cure to the neglected tropical diseases (NTDs) of humans and animals facing Africa, especially Nigeria.

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Cajachalcone: An Antimalarial Compound fromCajanus cajanLeaf Extract

Cited by 31 publications

References 23 publications

Antimalarial Activity of Plant Metabolites

Antimalarial Activity of Plant Metabolites

Antimalarial Activity of Plant Metabolites

Antimicrobial Importance of Medicinal Plants in Nigeria

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