Considerable progress has been made in modelling the response of rivers to tectonic perturbation in order to decode the tectonic signals embedded in river long profiles and planform geometry. Whilst studies have showed the importance of rock type on the morphology of rivers responding to tectonics on a local scale, these effects are often not captured in landscape evolution models. In fact, current models of fluvial response to tectonic perturbation such as active faulting require carefully collected data sets to fully constrain or calibrate key parameters, including the effect of bedrock lithology on substrate erodibility and timescales for tectonic signal propagation in bedrock river systems. Here we constrain the role of bedrock in controlling fluvial incision for a 240 km 2 catchment draining into the Gulf of Corinth, which has excellent tectonic constraints and a variety of bedrock lithologies. An active normal fault at the downstream end of the catchment (the East Eliki Fault) is known to have initiated at 0.7 Ma, with average Quaternary uplift and incision rates of 1.00-1.25 mm/yr. The initiation of the East Eliki Fault is recorded in the river as a prominent knickzone 7-16 km upstream of the fault. Detailed field data collected within this catchment at 500 m intervals along the main channel length at this tectonically wellconstrained field site show an order of magnitude increase in river channel slopes (y/x = 0.02 to 0.18) and stream powers (1 kWm -2 to 27 kWm -2 ) at the lithological boundary between weak and resistant bedrock. The weak conglomerates and strong limestones have Schmidt hammer compressive strengths of ca. 30 and 50 respectively, based on in-situ rock strength measurements. Consequent erodibility values of 1.8 ± 0.3 × 10 -14 and 5 -6 ± 2 × 10 -15 ms 2 kg -1 show a factor of three to four decrease in erodibility for a two-fold increase in rock strength. A simple simulation of tectonic signal propagation through the river catchment based on these erodibility values indicates that the observed plan view position of the knickpoint is consistent with our calculated knickpoint positions based on erodibility values derived from incision rate and stream power data. However, the tectonic signal associated with faulting would have propagated completely through the catchment within 1 Ma if it were entirely composed of weak rock for similar climatic and tectonic conditions, indicating that lithology has a major control on landscape response times.Our results help constrain the effect of lithology on river channel geometry and allow erosional parameters to be derived that are crucial for effective modelling of tectonic rates from topography.