Calcification of Hydroview H60M intraocular lenses: Aqueous humor analysis and comparisons with other intraocular lens materials

Abstract

The hydrophilic acrylic IOLs (Hydroview H60M) had significantly higher amounts of calcified deposits than IOLs of other materials, indicating that hydrophilic acrylic IOLs easily accumulate calcified deposits in the body when the concentrations of calcium, phosphate, and albumin in the aqueous humor fluctuate as a result of a blood-aqueous barrier breakdown.

Case-control study for clinical findings on intraocular lens opacity

“…Reports suggest some systemic diseases as etiologic agents for late IOL opacification, but do not confirm their hypotheses. 9,14,15,16 We found a significant number of patients with arterial hypertension in this study, but there was no correlation between the groups with and without IOL opacification, after 4 years of follow up. Hypertension is a common finding in a senior population; however, detailed investigations of blood and aqueous chemistry in these cases would be helpful in identifying metabolic disturbances that might contribute to dystrophic calcification, mainly if it plays a role in the breakdown of the blood-aqueous barrier.…”

“…Because the aqueous humor turns over every 90 minutes, it is significantly affected by concentrations of elements in the blood. 9 That is why long-term observation is necessary after implantation of hydrophilic acrylic IOLs, especially in cases in which bloodaqueous barrier breakdown is suspected, as may occur in diabetes, uveitis and vitrectomy. 19,20 The IOL opacification/discoloration has also been associated with the long-term use of systemic medications.…”

“…5,6 However, reported research does not have control groups for comparison to determine whether coexisting medical illness are risk factors for IOL calcification. 7,8,9 The aim of this study was to evaluate coexisting medical illnesses related to late Ioflex (Mediphacos, Minas Gerais, Brazil) IOL opacification, a foldable hydrophilic acrylic lens for posterior chamber implantation that has been marketed over ten years in several countries in Europe, Asia and Latin America.…”

Analysis of surface whitening of extracted hydrophobic acrylic intraocular lenses

“…[17][18][19] Experimentally, calcium phosphate deposition on AcrySof IOL optic surfaces has also been described. 20 Considering the characteristics of the AcrySof IOL, deposits of bioorganic substances, such as proteins on the optic surface, are another potential cause of light scattering. Therefore, to elucidate the mechanism of opacification (whitening), we evaluated the effects of biologic deposits on IOL surface opacification and examined relationships between whitening and water molecules.…”

Complicações oculares tardias após o implante de lente intraocular acrílica hidrofílica em olhos submetidos à cirurgia de catarata

“…Existe uma ampla variação na apresentação clínica e patológica das LIOs opacificadas, o que permite sugerir que a causa para tal fenômeno não seja a mesma para todos os casos 18,19 .…”