Calcified Adrenal Metastasis of High-Grade Osteosarcoma on FDG PET/CT

Filizoğlu, Nuh; Engur, Ceren Ozge; Türköz, Hüseyin Kemal; Öneş, Tunç; Erdıl, Tanju Yusuf

doi:10.1097/rlu.0000000000003395

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Osteosarcoma (OS) is the most prevalent primary bone malignant tumor in children and adolescents [ 1 ], characterized by high rate of metastasis and poor prognosis [ 2 , 3 ]. The annual incidence of OS is approximately 0.0004–0.0005% [ 4 ], which has been increasing at an annual rate of 1.4% in the past decade [ 5 ].…”

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confidence: 99%

Construction and Validation of an Autophagy-Related Prognostic Model for Osteosarcoma Patients

Lei

et al. 2021

Journal of Oncology

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While the prognostic value of autophagy-related genes (ARGs) in OS patients remains scarcely known, increasing evidence is indicating that autophagy is closely associated with the development and progression of osteosarcoma (OS). Therefore, we explored the prognostic value of ARGs in OS patients and illuminate associated mechanisms in this study. When the OS patients in the training/validation cohort were stratified into high- and low-risk groups according to the risk model established using least absolute shrinkage and selection operator (LASSO) regression analysis, we observed that patients in the low-risk group possessed better prognosis ( P < 0.0001 ). Univariate/Multivariate COX regression and subgroup analysis demonstrated that the ARGs-based risk model was an independent survival indicator for OS patients. The nomogram incorporating the risk model and clinical features exhibited excellent prognostic accuracy. GO, KEGG, and GSVA analyses collectively indicated that bone development-associated pathway mediated the contribution of ARGs to the malignance of OS. Immune infiltration analysis suggested the potential pivotal role of macrophage in OS. In summary, the risk model based on 12 ARGs possessed potent capacity in predicting the prognosis of OS patients. Our work may assist clinicians to map out more reasonable treatment strategies and facilitate individual-targeted therapy in osteosarcoma.

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