Calcified Brain Metastasis

Hwang, Te-Long; Valdivieso, Jose G.; Yang, Change-Hsu; Wolin, Mitchell J.

doi:10.1227/00006123-199303000-00018

Cited by 20 publications

(7 citation statements)

References 16 publications

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“…Calcified brain tumors tend to remain quiescent without progression. 7 , 10) Considering the long periods of time required to develop calcium deposits, calcification appears more frequently in benign cysts or slow-growing tumors. On the other hand, loss of calcification indicates accelerated growth of malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Calcified metastases to the brain have been described in patients with squamous cell carcinoma of the lung, 7) adenocarcinoma of the lung, 3) sarcoma of the mediastinum, 13) squamous cell carcinoma of the cervix, 4) adenocarcinoma of the pancreas, 1) and non-Hodgkin's lymphoma. 16) Only four cases of calcified metastases to the brain arising from a primary ovarian carcinoma have been described.…”

Section: Introductionmentioning

confidence: 99%

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Slow Progression of Calcified Cerebellar Metastasis From Ovarian Cancer: A Case Report and Review of the Literature

Kawamura

Tanaka

Fuga

et al. 2013

Neurol. Med. Chir.(Tokyo)

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The report describes a rare case of a patient with a calcified cerebellar metastasis arising from a primary ovarian cancer. The patient was a 33-year-old woman with a long history of stage IIIc ovarian cancer who had undergone transabdominal hysterectomy and bilateral oophorectomy followed by chemotherapy with gemcitabine hydrochloride. Incidentally, computed tomography (CT) revealed a cerebellar tumor with calcification. The size of the tumor gradually increased, and lateral suboccipital craniotomy was performed for gross total removal of the tumor. The histological diagnosis was ovarian mucinous adenocarcinoma. The patient's postoperative course was uneventful, and she was discharged two days after surgery. Brain metastases from ovarian cancer are rare. In the review of metastatic brain tumors arising from a primary ovarian cancer in the Department of Obstetrics and Gynecology at our institution, this phenomenon was noted in only 10 cases (0.24%) of 4,158 patients with ovarian cancer seen at our center over a period of 8 years. Moreover, only three cases of calcified metastatic brain tumor have been reported previously. In conclusion, complete tumor resection may be an acceptable approach for patients with calcified metastatic tumors both for therapeutic considerations and to obtain tissue for confirmation of histopathological diagnosis. Metastatic brain tumors can be calcified, and should be considered within the differential diagnosis of calcified intracranial lesions to avoid any delay in diagnosis or treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Slow Progression of Calcified Cerebellar Metastasis From Ovarian Cancer: A Case Report and Review of the Literature

Kawamura

Tanaka

Fuga

et al. 2013

Neurol. Med. Chir.(Tokyo)

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“…Only one patient survived for as long as 2 years 7 months after removal of the metastatic brain tumor. 11) The calcified brain tumor remained stable without progression for at least 4 months before surgical resection in another case. 11) In our institute, MIB-1 index in nine recent cases of metastatic brain tumors was 28.4 ± 8.9% (mean ± SD).…”

Section: Discussionmentioning

confidence: 88%

“…Calcification in intracranial metastasis is detected by radiography in 1-1.5% of cases, 10,14) and by computed tomography (CT) in 3.5% of cases. 5) Several cases of calcified metastases to the brain have been reported in cases of non-Hodgkin's lymphoma, 19) undifferentiated sarcoma of mediastinum, 18) squamous cell carcinoma of the cervical cancer, 8) squamous cell carcinoma of the lung, 11) squamous cell carcinoma of the unknown origin, 17) adenocarcinoma of the ovary, 3) adenocarcinoma of the lung, 7) and adenocarcinoma of the pancreas. 1) The median survival of patients suffering from metastatic brain tumors without medical treatment is about one month from the time of diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Calcified Metastatic Brain Tumor. Two Case Reports.

Ohmoto

Nishizaki

Kajiwara

et al. 2002

Neurol. Med. Chir.(Tokyo)

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A 29-year-old man and a 46-year-old woman presented with calcified brain metastasis from pulmonary adenocarcinoma. Both patients had a relatively benign clinical course and prolonged survival after total removal of the tumors. The male patient was still alive 2 years 3 months after surgical resection of the metastatic and primary tumors. The female patient had had brain metastasis 8 years after surgical resection of lung cancer, and survived for 3 years 3 months after removal of the brain metastasis. The MIB-1 indexes of the two cases were relatively low compared with other cases of brain metastases. Calcification and low MIB-1 index may indicate longer survival in patients with metastatic tumors if the primary tumor is controlled.

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“…This is thought to be due the long period of time required to develop calcium deposition. Therefore calcification of brain metastases has been proposed as an indicator of slow progression and longer survival 3 , although results in the literature remain controversial 4 . Pulmonary adenocarcinoma has been consistently reported as the most common primary tumor 4 though calcification seems to be especially associated with metastases from osteogenic osteosarcoma 5 .…”

Section: Discussionmentioning

confidence: 99%

Calcified Brain Metastases from Osteosarcoma

Pablo-Fernández

Gómez-Herrera

Sierra-Hidalgo

et al. 2013

Can. J. Neurol. Sci.

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Can J Neurol Sci. 2013; 40: 247-248 Brain metastases are the most frequent intracranial lesions but they rarely contain calcium. Calcium deposits were microscopically found in only 6.6% of patients in classic histopathological series 1 . They are even rarer in routine clinical practice and they are described in the literature as isolated case reports or case series. Despite the lack of recent studies with modern scans, they were identified on computed tomography in up to 5.8% of 121 patients 2 . Calcification patterns are often described as punctuate, curvilinear or heterogenous. We report a patient with brain metastases from an osteosarcoma of the mandible with unusual extensive homogeneous calcification. CASE REPORTA 48-year-old male presented with subacute left side weakness progressing over a few days. One year before, he had been diagnosed with osteogenic osteosarcoma of the mandible confirmed histologically. Further investigations, including a computed tomography of the body, revealed lung and bone metastases. Neuroimaging was not performed at that time due to the lack of neurological symptoms. Despite treatment with aggressive surgical resection of the mandibular lesion and neoadjuvant chemotherapy with different regimens, subsequent imaging investigations showed evident progression in size and number of the metastatic lesions affecting bones and lungs.On examination he presented mild weakness affecting the left limbs with associated ipsilateral brisk reflexes and upgoing plantar response. Brain computed tomography showed two large round lesions in the right centrum semiovale with an extensive homogeneous calcification resembling 'stones' and associated surrounding edema and mass effect (Figure). These abnormal radiological findings were consistent with calcified brain metastases from osteosarcoma of the mandible. The patient received palliative treatment and passed away a few days after his admission. No post-mortem histological examination of the lesions was performed. DISCUSSIONCalcium deposits are more common in benign cysts or slowgrowing tumors but brain metastases rarely calcify. This is thought to be due the long period of time required to develop calcium deposition. Therefore calcification of brain metastases https://www.cambridge.org/core/terms. https://doi

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Calcified Brain Metastasis

Cited by 20 publications

References 16 publications

Slow Progression of Calcified Cerebellar Metastasis From Ovarian Cancer: A Case Report and Review of the Literature

Slow Progression of Calcified Cerebellar Metastasis From Ovarian Cancer: A Case Report and Review of the Literature

Calcified Metastatic Brain Tumor. Two Case Reports.

Calcified Brain Metastases from Osteosarcoma

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