Calcified subcutaneous arterioles with infarcts of the subcutis and skin (“calciphylaxis”) in chronic renal failure

Janigan, David T.; Hirsch, David J.; Klassen, Gerald A.; Macdonald, A. S.

doi:10.1016/s0272-6386(00)70003-5

Cited by 143 publications

(101 citation statements)

References 84 publications

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“…Serve's animal model (12) (14), uremic small artery disease ( 16), subcutaneous calcific arteriolopathy with infarcts of the subcutis and skin (17). Janigan et al (17) emphasized that calcific arteriolopathy develops slowly, sometimes over years, and silently, whereas the infarctions are acute and clinically dramatic.…”

Section: Discussionmentioning

confidence: 99%

“…Janigan et al (17) emphasized that calcific arteriolopathy develops slowly, sometimes over years, and silently, whereas the infarctions are acute and clinically dramatic. In the present case, we considered that it was unlikely that atherosclerosis affecting large vessels played a role in causing compromised blood flow to the upper and lower extremities; thus, the onset of skin discoloration and painful lesions on the fingers and toes and mesenteric ischemia was suggestive of calciphylaxis.…”

Section: Discussionmentioning

confidence: 99%

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Calciphylaxis in a Patient with End-Stage Renal Disease Secondary to Systemic Lupus Erythematosus Associated with Acral Gangrene and Mesenteric Ischemia.

et al. 2001

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Apatient with end stage renal disease secondary to systemic lupus erythematosus (SLE) ultimately required amputation of the four extremities and developed mesenteric ischemia. The patient presented with widespread medial calcification involving various small to mediumsized arteries, although no noticeable secondary hyperparathyroidism was observed. We speculated that SLEassociated with systemic vasculitis and uremicmilieu over a numberof years may represent the perfect preexisting condition for calcific arteriolopathy to occur following which several factors including chronic administration of corticosteroids, photosensitivity in lupus, and significant weight loss may have contributed to acral gangrene and mesenteric ischemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Calciphylaxis in a Patient with End-Stage Renal Disease Secondary to Systemic Lupus Erythematosus Associated with Acral Gangrene and Mesenteric Ischemia.

et al. 2001

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“…Painful and non-healing skin ulcers are clinically observed with progression and can result in evident morbidity and mortality. The lesions characteristically appear on the lower extremity, partially on the gluteal zone and rarely on the abdomen, upper extremity and penis (2). In hemodialysis patients, the incidence is around 1%, and the prevalance 4.1% (3).…”

Section: ıNtroductıonmentioning

confidence: 99%

Metastatic Calcification and Calciphylaxis in a Hemodialysis Patient

Sipahi¹,

Uçar²,

Yayci³

et al. 2014

Turk Neph Dial Transpl

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While metastatic calcifications are frequently observed in patients treated with dialysis, calciphylaxis remains as a rare but a life-threatening complication. Calciphylaxis results in tissue ischemia and necrosis and is highly progressive. In this case, we report a rapidly progressing calciphylaxis case as well as pointing to the significance of early diagnosis and treatment and the need for a multidisciplinary approach.keY wordS: Calciphylaxis, Chronic renal failure, Hemodialysis ÖzDiyaliz tedavisi gören hastalarda metastatik kalsifikasyon sıklıkla gözlenmekle beraber, kalsiflaksi nadir ve hayatı tehdit eden bir komplikasyondur. Kalsiflaksi doku iskemi ve nekrozu sonucu oldukça hızla ilerler. Bu yazıda, hızlı ilerleyen bir kalsiflaksi olgusunun erken tanı ve multidisipliner yaklaşımla tedavisini sunduk.anahtar Sözcükler: Kalsiflaksi, Kronik böbrek yetmezliği, Hemodiyaliz

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“…Calciphylaxis (or calcific uremic arteriolopathy) has been described as an uncommon but dreaded complication of renal failure characterized by nodular or plaque-like subcutaneous calcification and painful tissue necrosis often leading to ulceration and secondary infection (1)(2)(3)(4). Mortality rates range from 30% in patients with plaquelike lesions and no ulceration to greater than 80% in patients presenting with or developing ulcerations (3,5).…”

Section: Introductionmentioning

confidence: 99%

Superior vena cava syndrome complicating calcific uremic arteriolopathy in an ESRD male patient on maintenance hemodialysis following failed kidney transplantation

Onuigbo¹,

Agbasi²,

Khan³

et al. 2017

J Parathyr Dis

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We described the unusual presentation of right unilateral facial swelling in a 48-year old end-stage renal disease (ESRD) male patient on maintenance hemodialysis following a failed kidney transplant. This was subsequently confirmed to be secondary to the extrinsic compression of the superior vena cava (SVC) by a large lobulated amorphous extra-osseous right axillary mass lesion that extended into the upper right thoracic outlet. Superior vena cava venogram and balloon angioplasty led to symptomatic relief. The factors involved in the pathogenesis of calciphylaxis are discussed and the available therapeutic options for this rare albeit debilitating disease are reviewed. Keywords: Calciphylaxis, Uremic arteriolopathy, Hemodialysis, Chronic kidney disease, Calcimimetics, End-stage renal disease Please cite this paper as: Onuigbo MAC, Khan A, Nijhawan V, Jiang Z. Superior vena cava syndrome complicating calcific uremic arteriolopathy in an ESRD male patient on maintenance hemodialysis following failed kidney transplantation J Parathyr Dis. 2018;6(2):68-71.

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Calcified subcutaneous arterioles with infarcts of the subcutis and skin (“calciphylaxis”) in chronic renal failure

Cited by 143 publications

References 84 publications

Calciphylaxis in a Patient with End-Stage Renal Disease Secondary to Systemic Lupus Erythematosus Associated with Acral Gangrene and Mesenteric Ischemia.

Calciphylaxis in a Patient with End-Stage Renal Disease Secondary to Systemic Lupus Erythematosus Associated with Acral Gangrene and Mesenteric Ischemia.

Metastatic Calcification and Calciphylaxis in a Hemodialysis Patient

Superior vena cava syndrome complicating calcific uremic arteriolopathy in an ESRD male patient on maintenance hemodialysis following failed kidney transplantation

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