Calcifying Epithelial Odontogenic Tumour with Clear Langerhans Cells: A Novel Variant, Report of a Case and Review of the Literature

Abstract

. We further suggest that the contradictory term ''non-calcifying variant of calcifying epithelial odontogenic tumour with LC'' to be abandoned, as the current case clearly indicates that LC could be seen in CEOT irrespective of the presence or absence of calcifications.

Calcifying epithelial odontogenic tumours: Collaborative study of 32 cases and review of literature

“…It is a rare lesion of the jaws and, to the best of our knowledge, less than 400 cases have been described in the literature (Chrcanovic & Gomez, ). CEOT displays a variety of architectural patterns, and three variants have been described: the Langerhans cell CEOT, the clear‐cell variant and the microcyst variant (Abrams & Howell, ; Afrogheh, Schneider, Mohamed, & Hille, ; Asano et al., ; Hicks, Flaitz, Wong, McDaniel, & Cagle, ; Sánchez‐Romero, Carlos, de Almeida, & Romañach, ; Takata et al., ). A few cases of locally aggressive CEOTs invading adjacent structures (Mohtasham, Habibi, Jafarzadeh, & Amirchaghmaghi, ) and less than 10 cases of malignant transformation of CEOT have been reported in the literature so far (Chrcanovic & Gomez, ).…”

Peripheral Calcifying Epithelial Odontogenic Tumour Mimicking a Gingival Inflammation: A Diagnostic Dilemma

“…With regard to the differential diagnosis, the peripheral CEOT can resemble clinically or histologically several other lesions such as peripheral odontogenic tumours, odontogenic carcinoma with dentinoid, clear cell odontogenic carcinoma with dentinoid, minor salivary gland tumours, tumour metastasis, reactive hyperplasia, and acute gingival inflammations [9]. According to Shetty et al (2016), presence of amyloid material, calcifications, absence of mitoses, immunohistochemical positivity to cytokeratin 14, and absence of S-100 protein expression can help to perform a final diagnosis [1].…”

“…Although authors have described the potential reoccurrence of clear cell CEOT [9], studies showed evidence that soft tissue variants are less severe neoplasia as they usually have small sizes (i.e., 0.5 to 2 cm), preserve osseous tissue, and do not tend to relapse if properly removed [1]. Only one case described by Shetty et al (2014) showed an atypical presentation of peripheral CEOT with great dimensions and calcifications and was treated through maxillectomy [4].…”

Clear cell variant of calcifying epithelial odontogenic tumor: Case report with immunohistochemical findings

“…Since then, less than 40 cases of clear cell variant of CEOT have been documented in the literature so far ( 2 - 6 ). Although some authors have claimed that CEOT composed mainly by clear cells might progress in a more aggressive clinical course with increased rate of recurrence, the proper clinical relevance regarding its biological behavior remains a subject of controversy ( 4 - 6 , 8 ).…”

“…Some years later, Krolls and Pindborg considered two of those 23 cases of CEOT as a diagnostic challenge due their high content of clear cells. Since then, the predominance of the clear cell component in CEOTs has been reported mainly through single cases and its prognostic importance is still debatable ( 1 - 8 ). We report an additional case of clear cell variant of CEOT with immunohistochemical findings.…”