Calcifying Fibrous Pseudotumor of the Esophagus

Abstract

Calcifying fibrous pseudotumor is an uncommon lesion and has recently been recognized as a distinctive fibrous lesion. Esophageal calcifying fibrous pseudotumor is extremely rare and, to the best of our knowledge, has never been reported before. A 54-year-old woman underwent upper gastrointestinal endoscopy and endoscopic ultrasound because of intermittent dysphagia. The results showed 1 isoechoic esophageal submucosal tumor over the deep mucosa and submucosal layers, with calcifications inside. The patient underwent tumor excision, and the diagnosis was confirmed by pathological features, with abundant collagen, calcification and inflammatory cell infiltration. She received regular follow-up at the clinic and no evidence of tumor recurrence was found.

Calcifying Fibrous Tumor

“…1 , 7 , 30 – 36 In a case report, the patient complained about a foreign body sensation in throat, whereas in another case of CFT of the spine, the patient noticed a flank pain in spine with worsening intensity. 37 , 38 In the thoracic cavity, CFT may cause chest or back pain, fever, dyspnea, systolic heart murmur, shortness of breath or ecchymosis, and erythema. 3 , 6 , 18 , 39 – 49 Intrabdominal CFTs present with a great variety of symptoms, both general and more specific.…”

Calcifying Fibrous Tumor of the Gastrointestinal Tract

“…3,4,6,14,[17][18][19][20][21][22][23][24][25] Three examples in the large intestine exist 14,17,26 and a single case in the esophagus. 27 Patient age ranges from 5 to 77 years, with a mean of 40.8 years; no sex predilection is evident. Multiple lesions were documented in 11 of 43 patients, many of which had concurrent extra-GI involvement, with the most common site being the mesentery.…”

“…Endoscopic ultrasonography may reveal a hypoechoic mass with internal hyperechoic calcifications. 27 If imaged by computed tomographic scan, a well-circumscribed, homogeneous mass with mild enhancement and scattered calcifications may be identified. 13,16,23,24,27 One study 7 describes magnetic resonance imaging findings as isosignal intensity on gadolinium-enhanced T1-weighted imaging and as hyposignal intensity on T2-weighted imaging.…”

“…Calcifying fibrous tumor of the esophagus has been treated by excision. 27 Calcifying fibrous tumors in the stomach have been treated by wedge resection. 5,9,15,16 Intestinal examples have been predominantly treated by segmental resection, although enucleation has also been performed.…”

Histopathological landscape of rare oesophageal neoplasms

“…Background: Calcifying fibrous tumours are rare benign fibroblastic tumours that affect both sexes equally and are more typical of children and young adults than older patients[ 23 ]. These neoplasms may develop in many different anatomic sites (gastric location being the most common), but oesophageal calcifying fibrous tumours (OCFTs) are extremely rare, with fewer than ten cases described in the medical literature[ 23 - 25 ].…”