Calcifying odontogenic cyst: clinicopathological features and immunohistochemical profile of 10 cases

Fregnani, Eduardo Rodrigues; Pires, Fábio Ramôa; Quezada, Rivera Daniel; Shih, Ie Ming; Vargas, Pablo Agustı́n; Almeida, Oslei Paes de

doi:10.1034/j.1600-0714.2003.00070.x

Cited by 70 publications

(63 citation statements)

References 24 publications

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“…In the present study, the frequency of calcifying odontogenic cysts (2.8%) was higher than that reported in previous studies in which these lesions accounted for 1.0% or less of all OCs (2,3). In contrast to other reports (2,20), in the present series most cases were diagnosed in women. Regarding anatomic location, our results showed a similar distribution in the mandible and maxilla.…”

Section: Discussioncontrasting

confidence: 54%

“…Studies performed in Europe (2) and Chile (3) showed that odontogenic keratocysts accounted for 18.1% and 23.3% of all OCs diagnosed in pediatric populations, respectively. The clinical and histopathologic features of calcifying odontogenic cysts have generated disagreement and confusion regarding their classification and terminology (20). On the basis of the new WHO concept, calcifying odontogenic cysts not only contain a neoplasm but also a cyst (3).…”

Section: Discussionmentioning

confidence: 99%

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Odontogenic cysts: Demographic profile in a Brazilian population over a 38-year period

Souza

Gordón-Núñez²,

Nonaka³

et al. 2010

Med Oral

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Objective: To determine the distribution of odontogenic cysts diagnosed histologically over a period of 38 years in a Brazilian population according to age, gender and site affected and to compare these data with previously reported studies from other countries. Study design: A total of 1019 cases of odontogenic cysts diagnosed between 1970 and 2007 were studied. Clinical features obtained from the patient records and microscope slides were reviewed according to the 1992 World Health Organization classification. Results: The mean age was 31.0 years, and there was a predominance of females. The most frequent odontogenic cysts were radicular cysts (61.4%), followed by dentigerous cysts (20.1%) and odontogenic keratocysts (6.4%). Radicular cysts were more frequent in females (62.0%), and the maxillary teeth were the site most commonly involved (63.05%). The peak incidence of dentigerous cysts occurred in the second decade of life, with the posterior region of the mandible being the site most affected (46.3%), followed by the anterior region of the maxilla (27.8%). Odontogenic keratocysts showed a peak incidence between the third and fourth decades of life and predominance among females. The posterior region of the mandible was the site most frequently affected (65.6%). Conclusion: The present results showed a similar frequency of odontogenic cysts in this Brazilian population and other populations around the world, with inflammatory cysts being identified as the most frequent odontogenic cyst. Radicular cysts, dentigerous cysts, and odontogenic keratocysts are the most common cystic lesions, accounting for 87.9% of all odontogenic cysts.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Odontogenic cysts: Demographic profile in a Brazilian population over a 38-year period

Souza

Gordón-Núñez²,

Nonaka³

et al. 2010

Med Oral

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“…To summarize the data, the review of cases was performed in the following manners: first, the data from reviews carried out in 1991 by Buchner et al [7] were used; to confirm the information, all works described by these authors between 1962 and 1991 [1,2,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] were reviewed. Second, the papers from 1991 to 2010 [5,[22][23][24][25][26] were analyzed. Together with this current case report, a total of 44 acceptable cases of PCOC for evaluation and analysis were selected.…”

Section: Discussionmentioning

confidence: 99%

Peripheral Calcifying Odontogenic Cyst: A Case Report and Review of the Literature

Resende

Brito

Souza

et al. 2010

Head and Neck Pathol

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The peripheral calcifying odontogenic cyst (PCOC) accounts for less than 25% of the cases of calcifying odontogenic cysts and most commonly appears as a nodule on the gingiva. This paper aims to present both a case report of a PCOC located in the left vestibular maxilla as well as a review of the English-language literature. An 11-year-old female patient presented a swelling in the vestibular region of teeth 12 and 13. Periapical and panoramic radiographs demonstrated irregular calcification. Surgical excision was performed. Microscopic examination showed an odontogenic cystic lesion lined by ameloblastoma-like epithelium, containing numerous ghost cells. Areas of calcification associated with ghost cells could also be observed. The patient was diagnosed with PCOC. The patient has been disease-free for 36 months. The review of the cases of PCOC showed 44 well-defined cases. The mean age was of 49.4 years at the time of diagnosis. The reported cases appeared as a painless swelling, with a slight predilection for females, and were more frequently located in the anterior region of the maxilla or mandible. Surgical excision is the treatment of choice, and recurrence is rare.

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“…COC represents approximately 5-7% of odontogenic tumors and 1% of all cysts of the jaw (1,6). Most cases (70%) are intraosseous lesions almost equally affecting the maxilla and mandible, with a predilection to the anterior regions (2,6).…”

Section: Discussionmentioning

confidence: 99%

“…Ameloblastomatous proliferating 4. Dentinogenic ghost cell tumor In 1992, the World Health Organization (WHO) classified COC as a neoplasm rather than a cyst, but confirmed that most cases are neoplastic (6). In 1998, Toida suggested a classification that included three main subdivisions of COC: cystic, neoplastic and combined lesions.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical analysis of p53 and PCNA expression in calcifying odontogenic cyst

et al. 2010

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Calcifying odontogenic cyst (COC) is adevelopmental odontogenic cyst in the jaw. Because of its diverse histopathologic features and biological behavior, there has long been confusion with regard to its nature as a cyst or neoplasm. This study evaluated the proliferative activity of 57 COC samples, including simple cyst (10 cases), cystic neoplasm (34 cases), solid neoplasm (6 cases) and combined lesion (7 cases) by p53 and PCNA immunohistochemical staining. For assessment of p53 and PCNA positivity, the number of positively stained cells with brown-stained nuclei was counted in 1000 cells from each sample. p53 and PCNA expression in the solid neoplasm subtype were significantly higher when compared to cystic neoplasm and simple cyst (P < 0.05). The lowest p53 and PCNA expression was found in the simple cyst subtype. p53 and PCNA expression in the basal and suprabasal layers was significantly higher in the solid subtype when compared to others, and the difference between COC groups was significant. The results demonstrated that within benign types of COC, the amount of p53 and PCNA in proliferative epithelium is significantly higher when compared to non-proliferative epithelium.

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Calcifying odontogenic cyst: clinicopathological features and immunohistochemical profile of 10 cases

Abstract: Calcifying odontogenic cysts showed odontogenic cytokeratin profile and bcl-2 and Mel-CAM expression indicate that these proteins may be involved in the development of COC. There were no recurrences after surgery, irrespective of their proliferative activity.

Cited by 70 publications

References 24 publications

Odontogenic cysts: Demographic profile in a Brazilian population over a 38-year period

Odontogenic cysts: Demographic profile in a Brazilian population over a 38-year period

Peripheral Calcifying Odontogenic Cyst: A Case Report and Review of the Literature

Immunohistochemical analysis of p53 and PCNA expression in calcifying odontogenic cyst

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