Calcinosis in a roe deer fawn (Capreolus capreolus) in northern Germany

Wagener, Matthias Gerhard; Lehmbecker, Annika; Bühler, Melanie; Wilkens, Mirja R.; Punsmann, Teresa; Ganter, Martin

doi:10.1186/s12917-020-02615-w

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…However, in contrast to the alpaca crias described here, hypocalcemia was present in these animals [ 50 ]. Similar findings were obtained in a fawn in which inflammatory changes in the kidneys were accompanied by azotemia, hyperphosphatemia and also hypocalcemia [ 51 ].…”

Section: Discussionsupporting

confidence: 82%

Calcinosis in Alpaca Crias (Vicugna pacos) Due to Vitamin D Intoxication—Clinical, Laboratory and Pathological Findings with a Focus on Kidney Function

Wagener

Helmer

Kammeyer

et al. 2021

Animals

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Alpacas kept in Central Europe are often deficient in vitamin D3, which is supplemented orally or by injection by the owners or veterinarians. Vitamin D3 can be specified in two different units (IU and µg), which differ by a factor of 40. By mixing up these units, an overdosage can be induced. In this study, three alpaca crias were examined after vitamin D3 intoxication, with particular reference to kidney function. All three animals developed non-specific clinical alterations 1–2 weeks after a vitamin D3 overdose of approximately 40 times. Plasma of the animals revealed several alterations. The main findings were severe azotemia, hypercalcemia and hyperphosphatemia, 15 days after treatment. Kidney function analysis (endogenous creatinine clearance) in two of the crias revealed severe glomerular damage. All crias died despite intensive treatment within 23 days after vitamin D3 treatment. Necropsy revealed calcification in different organs, mainly the kidneys, lungs and liver. Since nine other crias in the same group were treated with comparable doses of vitamin D3 and no clinical signs were observed in these animals, it is concluded that individual animals show different levels of sensitivity to vitamin D3.

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Section: Discussionsupporting

confidence: 82%

Calcinosis in Alpaca Crias (Vicugna pacos) Due to Vitamin D Intoxication—Clinical, Laboratory and Pathological Findings with a Focus on Kidney Function

Wagener

Helmer

Kammeyer

et al. 2021

Animals

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Pathological and incidental findings in anurans from Ceará, northeastern Brazil

Braga,

Castro,

Lima

et al. 2024

Ciênc. anim. bras.

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Amphibians are among the most threatened animal groups on Earth, with anurans representing the most prevalent order within this group. Globally, emerging infectious diseases are linked to the decline of amphibian populations, a phenomenon also observed in northeastern Brazil. In particular, the state of Ceará boasts a rich and abundant anurofauna, with nearly 5% of its species considered critically endangered. Despite numerous pathologies observed in local anurans through research projects, published cases remain scarce. This study aimed to compile pathological and incidental findings in native anurans from Ceará State, Northeastern Brazil. Data were derived from necropsies and clinical examinations conducted on 38 specimens across 13 species from 13 sites, spanning from 2010 to 2022. Most lesions (71 %, n = 38) indicated inflammatory pathophysiology, with observations of parasitic infections and agents within lesions, granulomatous or necrotic lesions with intracytoplasmic inclusions consistent with Mycobacteria ana Ranavirus infections, respectively. Fibrolipomas and hepatocellular carcinoma presented as single solid nodules, the latter associated with cystic helminth infections. Diffuse hepatic calcinosis suggested a toxic/metabolic etiology. Bilateral cataract was the most common ocular alteration (60%, n=5), though its etiology remained undetermined. The presence of infectious diseases was confirmed, and further etiological diagnostics are necessary. The lack of specific etiological techniques constrained some definitive diagnoses. These findings place Ceará on the distribution map for significant diseases affecting anurofauna, underscoring the need for ongoing monitoring.

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Achados patológicos e incidentais em anuros do Ceará, nordeste brasileiro

Braga,

Castro,

Lima

et al. 2024

Ciênc. anim. bras.

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Resumo Anfíbios são um dos grupos de vertebrados mais ameaçados globalmente, e os anuros são sua ordem mais representativa. Doenças infecciosas emergentes têm sido associadas ao declínio global das espécies de anfíbios, fenômeno relatado em todo o mundo. Na região Nordeste, o Ceará tem uma abundante anurofauna, com cerca de 5% de suas espécies sendo consideradas criticamente ameaçadas. Em projetos de pesquisa, várias patologias são observadas em anuros silvestres locais, contudo, poucos casos têm sido publicados. O objetivo deste trabalho foi reunir achados patológicos e incidentais em anuros nativos do estado do Ceará, nordeste do Brasil. Os achados foram registrados durante necrópsias e exames clínicos. A amostra incluiu 38 espécimes, distribuídos em 13 espécies, originários de 13 localidades, examinados entre 2010 e 2022. A maioria das lesões (71%, n = 38) apontou para fisiopatologia inflamatória, incluindo infecções parasitárias com agentes lesionais - lesões granulomatosas e necrotizantes com inclusões intracitoplasmáticas, compatíveis com Mycobacteria e Ranavírus, respectivamente. Fibrolipoma e carcinoma hepatocelular se apresentaram como nódulos únicos, estando o último associado a uma infecção helmíntica cística. Calcinose hepática difusa representou doença de etiologia tóxico/metabólica. Catarata bilateral foi a alteração ocular mais frequente (60%, n=5), mas sem diagnóstico etiológico conclusivo. Indícios de doenças infecciosas foram detectados e necessitam de técnicas complementares de diagnóstico etiológico. A falta de laboratórios locais ou parceiros com técnicas diagnosticas específicas limitou alguns diagnósticos definitivos. Os achados aqui apresentados colocam o estado do Ceará no mapa de doenças preocupantes da anurofauna, que necessitam ser monitoradas.

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Calcinosis in a roe deer fawn (Capreolus capreolus) in northern Germany

Cited by 3 publications

References 20 publications

Calcinosis in Alpaca Crias (Vicugna pacos) Due to Vitamin D Intoxication—Clinical, Laboratory and Pathological Findings with a Focus on Kidney Function

Calcinosis in Alpaca Crias (Vicugna pacos) Due to Vitamin D Intoxication—Clinical, Laboratory and Pathological Findings with a Focus on Kidney Function

Pathological and incidental findings in anurans from Ceará, northeastern Brazil

Achados patológicos e incidentais em anuros do Ceará, nordeste brasileiro

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