Calcitonin gene‐related peptide inhibits exocrine secretion from the rat pancreas by a neurally mediated mechanism

Bunnett, Nigel W.; Sj, Mulvihill; Ht, Debas

doi:10.1113/expphysiol.1991.sp003473

Cited by 17 publications

(7 citation statements)

References 17 publications

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“…The likely mechanism of action involved somatostatin and also sympathetic noradrenergic efferent nerves via ␣-adrenergic receptors (122). Another study using perfused rat pancreas and isolated pancreatic acinar cells confirmed that CGRP inhibited stimulated secretion in vivo, but not in vitro (26). The effect of CGRP was probably indirect, possibly involving cholinergic muscarinic transmission.…”

Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 84%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

106

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Although the role of the islets in the regulation of acinar cell function seemed a mystery to investigators who observed their dispersion among pancreatic acini, over time an appreciation for this intricate and unique structural arrangement has developed. The last three decades have witnessed a steadily growing understanding of the interrelationship of the endocrine and the exocrine pancreas. The islet innervation and vascular anatomy have been more fully characterized and provide an appropriate background for our current understanding. The interrelationship between the endocrine and exocrine pancreas is mediated by islet-derived hormones such as insulin and somatostatin, other humoral factors including pancreastatin and ghrelin, and also neurotransmitters (nitric oxide, peptide YY, substance P, and galanin) released by the nerves innervating the pancreas. Although considerable progress has been achieved, further work is required to fully delineate the complex interplay of the numerous mechanisms involved. This review aims to provide a comprehensive update of the current literature available, bringing together data gleaned from studies addressing the actions of individual hormones, humoral factors, and neurotransmitters on the regulation of amylase secretion from the acinar cell. This comprehensive view of the islet-acinar axis of the pancreas while acknowledging the dominant role played by insulin and somatostatin on exocrine secretion sheds light on the influence of the various neuropeptides on amylase secretion.

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Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 84%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

106

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“…Subpopulation of somatostatin cells (Fujimura et al 1988;Sternini et al 1992) CRLR not detected (Martinez et al 2000) ↓ HCO 3 Ϫ secretion a (Helton et al 1989;Bunnett et al 1991;Debas et al 1992 (Böttcher et al 1989) Yes (Jackerott and Larsson 1997)…”

Section: Other Islet Metabolites As Candidates To Influencementioning

confidence: 99%

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Bertelli

Bendayan

2005

J Histochem Cytochem.

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S U M M A R YTraditional histological descriptions of the pancreas distinguish between the exocrine and the endocrine pancreas, as if they were two functionally distinct glands. This view has been proven incorrect and can be considered obsolete. Interactions between acinar and islet tissues have been well established through numerous studies that reveal the existence of anatomical and functional relationships between these compartments of the gland. Less attention, however, has traditionally been paid to the relationships occurring between the endocrine pancreas and the ductal system. Associations between islet tissue and ducts are considered by most researchers as only a transient epiphenomenon of endocrine development. This article reviews the evidence that has emerged in the last 10 years demonstrating the existence of stable, close, and systematic relationships between these two pancreatic compartments. Functional and pathophysiological implications are considered, and the existence of an "acinar-duct-islet" axis is put forward. The pancreas appears at present to be an integrated organ composed of three functionally related components of well-orchestrated endocrine and exocrine physiological responses.

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“…The effects of CCK (10 Ϫ10 M) and secretin (10 Ϫ8 M), both alone and in combination, on pancreatic amylase and flow of pancreatic juice were exam-ined. The doses were selected based on prior experiments to achieve peak (two-to fourfold increase) stimulation of exocrine pancreatic secretion in this model (6). CCK was dissolved in 0.25% BSA-0.1% acetic acid, and secretin was dissolved in 0.1% BSA-normal saline.…”

Section: Methodsmentioning

confidence: 99%

“…CCK was dissolved in 0.25% BSA-0.1% acetic acid, and secretin was dissolved in 0.1% BSA-normal saline. For experiments with SP, neurokinin receptor antagonists, atropine, and TTX, the combination of CCK (10 Ϫ10 M) ϩ secretin (10 Ϫ8 M) was used to induce maximal pancreatic exocrine secretion (6). Unless otherwise specified, all drugs were reconstituted in 1 ml of a 0.1% BSA-normal saline solution before infusion via a sidearm of the aortic cannula.…”

Section: Methodsmentioning

confidence: 99%

Substance P inhibits pancreatic exocrine secretion via a neural mechanism

Kirkwood

Kim

et al. 1999

American Journal of Physiology-Gastrointestinal and Liver Physi

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We investigated the effects of the sensory neuropeptide substance P (SP) on amylase and fluid secretion in the isolated vascularly perfused rat pancreas. SP inhibited CCK-induced amylase release and secretin-induced juice flow via the pancreatic duct in a dose-related fashion. Threshold inhibition occurred following addition of 10−10 M SP to the perfusate, and maximal inhibition was seen with 10−8 M SP. The effects of SP were partially blocked by both the neurokinin-1 (NK1) and neurokinin-2 (NK2) receptor antagonists. Atropine and TTX blocked SP-induced effects on both amylase secretion (26 and 63% blockade, respectively) and pancreatic juice flow (21 and 79% blockade, respectively). Excitation of pancreatic sensory nerves using capsaicin (in the absence of SP) inhibited both amylase and pancreatic juice flow via activation of the NK1 receptor. We conclude that SP inhibits exocrine secretion via an indirect neural mechanism.

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Calcitonin gene‐related peptide inhibits exocrine secretion from the rat pancreas by a neurally mediated mechanism

Cited by 17 publications

References 17 publications

The islet-acinar axis of the pancreas: more than just insulin

The islet-acinar axis of the pancreas: more than just insulin

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Substance P inhibits pancreatic exocrine secretion via a neural mechanism

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