Calcitonin in bone-guided regeneration of mandibles in ovariectomized rats: densitometric, histologic and histomorphometric analysis

Arisawa, Emília Ângela Lo Schiavo; Brandão, Adriana Aigotti Haberbeck; Almeida, Janete Días; Rocha, Rosilene Fernandes da

doi:10.1016/j.ijom.2007.07.011

Cited by 16 publications

(26 citation statements)

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“…Densitometric studies have been performed to evaluate bone regeneration in osteoporosis. 3,9 This method has been shown to produce results similar to those of histological studies. 10 In the early 1960s, low doses of different light wavelengths were used for the treatment of specific diseases, with the main areas of application being the reduction of acute inflammation, stimulation of the tissue repair process, and pain relief.…”

Section: Introductionmentioning

confidence: 87%

“…Over the last 30 years, the number of studies on bone regeneration conducted to obtain new knowledge that could be applied to surgical reconstruction procedures, to bone repair, and to the use of implants has increased markedly. [1][2][3][4] A study using calcitonin showed faster bone repair in female castrated rats than in a control group; 3 different results were obtained for bone repair in male rats. 4 Bone turnover is a complex process in which bone formation and bone resorption are tightly linked in time and space.…”

Section: Introductionmentioning

confidence: 99%

“…5 Osteoporosis is the most frequent systemic disease when hormonal variations are present. 3,6 Several studies have investigated the ability of salmon calcitonin to inhibit bone resorption in patients with bone metabolism disorders. 3,4,6,7 This hormone favors bone formation, inhibits osteoclastic activity, and prevents osteopenia.…”

Section: Introductionmentioning

confidence: 99%

“…3,6 Several studies have investigated the ability of salmon calcitonin to inhibit bone resorption in patients with bone metabolism disorders. 3,4,6,7 This hormone favors bone formation, inhibits osteoclastic activity, and prevents osteopenia. 4,6,7 In vitro and in vivo studies have shown that this hormone stimulates the growth of bone tissue, 3,8 demonstrated by a decrease in inflammatory cell infiltration, tissue flattening, reduced number of lymphoid follicles, and other histological effects.…”

Section: Introductionmentioning

confidence: 99%

“…3,4,6,7 This hormone favors bone formation, inhibits osteoclastic activity, and prevents osteopenia. 4,6,7 In vitro and in vivo studies have shown that this hormone stimulates the growth of bone tissue, 3,8 demonstrated by a decrease in inflammatory cell infiltration, tissue flattening, reduced number of lymphoid follicles, and other histological effects. 8 Since 1994, the World Health Organization (WHO) has recommended bone densitometry as the criterion standard for the diagnosis of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Low-Level Laser Therapy and Calcitonin on Bone Repair in Castrated Rats: A Densitometric Study

Nascimento

Cardoso

Ribeiro

et al. 2010

Photomedicine and Laser Surgery

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Objective: To investigate the healing of bone defects in male rats treated with salmon calcitonin, low-level laser therapy (LLLT), or both. Background: Healing of bone defects still represents a challenge to health professionals in several areas. In this article, the effect of calcitonin in combination with LLLT on bone repair was studied. Densitometry was used as a valuable tool for the measurement of bone regeneration. Methods: Sixty male Wistar rats underwent bilateral castration surgery before the creation of a surgical bone defect. The animals were randomly divided into four groups: control, treated with calcitonin (Ca), treated with LLLT (La), and treated with calcitonin and LLLT (CaLa). Groups Ca and CaLa received 2 IU=kg of synthetic salmon calcitonin intramuscularly three times a week. Groups La and CaLa received laser therapy using a gallium-aluminum-arsenide laser (10 mW, 20 J=cm 2 , wavelength 830 nm). Control animals were submitted to sham irradiation. The animals were sacrificed 7, 14, and 21 days after surgery, and bone defects were analyzed using densitometry. Results: The CaLa group had a higher degree of bone regeneration 14 and 21 days after surgery. Conclusions: The La and CaLa had significantly higher bone mineral density than the control and Ca groups.

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Section: Introductionmentioning

confidence: 87%