Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons

Zak, Joseph D.; Grimaud, Julien; Li, Rong Chang; Lin, Chih Chun; Murthy, Venkatesh N.

doi:10.1038/s41598-018-28855-3

Cited by 20 publications

(19 citation statements)

References 54 publications

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“…Given the Ca 2+ permeability of some anoctamins, they may also serve as plasma membrane localized Ca 2+ channels [90,166,167,168] or ER Ca 2+ leakage channels [103,110,154,169,170,171]. Disturbed intracellular Ca 2+ signals with changes of cellular properties are detectable in naïve tissues and primary cells from mice with knockout of anoctamins [107,108,110,155,172,173,174] (Figure 4).…”

Section: Anoctamins Control Intracellular Ca2+ Levelsmentioning

confidence: 99%

Contribution of Anoctamins to Cell Survival and Cell Death

Kunzelmann

Ousingsawat

Benedetto

et al. 2019

Cancers

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Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1, TMEM16A) was known as DOG1, a marker protein for gastrointestinal stromal tumors (GIST). Meanwhile, ANO1 has been examined in more detail, and the role of ANO1 in cell proliferation and the development of different types of malignomas is now well established. While ANO5, ANO7, and ANO9 may also be relevant for growth of cancers, evidence has been provided for a role of ANO6 (TMEM16F) in regulated cell death. The cellular mechanisms by which anoctamins control cell proliferation and cell death, respectively, are just emerging; however, the pronounced effects of anoctamins on intracellular Ca2+ levels are likely to play a significant role. Recent results suggest that some anoctamins control membrane exocytosis by setting Ca2+i levels near the plasma membrane, and/or by controlling the intracellular Cl− concentration. Exocytosis and increased membrane trafficking induced by ANO1 and ANO6 may enhance membrane expression of other chloride channels, such as CFTR and volume activated chloride channels (VRAC). Notably, ANO6-induced phospholipid scrambling with exposure of phosphatidylserine is pivotal for the sheddase function of disintegrin and metalloproteinase (ADAM). This may support cell death and tumorigenic activity of IL-6 by inducing IL-6 trans-signaling. The reported anticancer effects of the anthelminthic drug niclosamide are probably related to the potent inhibitory effect on ANO1, apart from inducing cell cycle arrest through the Let-7d/CDC34 axis. On the contrary, pronounced activation of ANO6 due to a large increase in intracellular calcium, activation of phospholipase A2 or lipid peroxidation, can lead to ferroptotic death of cancer cells. It therefore appears reasonable to search for both inhibitors and potent activators of TMEM16 in order to interfere with cancer growth and metastasis.

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Section: Anoctamins Control Intracellular Ca2+ Levelsmentioning

confidence: 99%

Contribution of Anoctamins to Cell Survival and Cell Death

Kunzelmann

Ousingsawat

Benedetto

et al. 2019

Cancers

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“…The mucus composition is fundamental to maintain the ionic environment necessary for olfactory transduction. Indeed, the binding of odorant molecules to odorant receptors in the cilia of olfactory sensory neurons leads to a transduction cascade that includes the activation of CNG channels and the Ca 2+ -activated Cl − channels TMEM16B, whose function depends on the Cl − electrochemical gradient between the mucus and the intraciliary compartment (Pifferi et al, 2009; Stephan et al, 2009; Billig et al, 2011; Pietra et al, 2016; Dibattista et al, 2017; Neureither et al, 2017; Li et al, 2018; Zak et al, 2018; Reisert and Reingruber, 2019). Thus, the Cl − concentration regulated by TMEM16A would affect the TMEM16B-mediated current, modifying the odorant response of the olfactory sensory neurons.…”

Section: Discussionmentioning

confidence: 99%

TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium

Henriques

Agostinelli

Hernandez-Clavijo

et al. 2019

Journal of General Physiology

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“…This important piece of evidence has been complemented and basically confirmed by multiphoton activity recordings of ORN fibers in glomeruli of the OB. Odor-evoked responses in ORN axons of ANO2-knockout mice (ANO2 À/À ) were shown to be consistently larger for a variety of odorants and concentrations, clearly indicating that ANO2 channels limit the rate of action potentials in a volley of spikes during odor responses (238). Taken together, the functions of ANO2 channels appear contradictory.…”

Section: Transduction Mechanisms In Receptor Neuronsmentioning

confidence: 99%

Principles of odor coding in vertebrates and artificial chemosensory systems

Manzini

Schild

Natale

2022

Physiological Reviews

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The biological olfactory system is the sensory system responsible for the detection of the chemical composition of the environment. Several attempts to mimic biological olfactory systems have led to various artificial olfactory systems using different technical approaches. Here we provide a parallel description of biological olfactory systems and their technical counterparts. We start with a presentation of the input to the systems, the stimuli, and treat the interface between the external world and the environment where receptor neurons or artificial chemosensors reside. We then delineate the functions of receptor neurons and chemosensors as well as their overall I-O relationships. Up to this point, our account of the systems goes along similar lines. The next processing steps differ considerably: while in biology the processing step following the receptor neurons is the "integration" and "processing" of receptor neuron outputs in the olfactory bulb, this step has various realizations in electronic noses. For a long period of time, the signal processing stages beyond the olfactory bulb, i.e., the higher olfactory centers were little studied. Only recently there has been a marked growth of studies tackling the information processing in these centers. In electronic noses, a third stage of processing has virtually never been considered. In this review, we provide an up-to-date overview of the current knowledge of both fields and, for the first time, attempt to tie them together. We hope it will be a breeding ground for better information, communication, and data exchange between very related but so far little connected fields.

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Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons

Cited by 20 publications

References 54 publications

Contribution of Anoctamins to Cell Survival and Cell Death

Contribution of Anoctamins to Cell Survival and Cell Death

TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium

Principles of odor coding in vertebrates and artificial chemosensory systems

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