Calcium, An Overview—1989

Wiercinski, Floyd J.

doi:10.2307/1541979

Cited by 13 publications

(11 citation statements)

References 166 publications

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“…Depending upon the physiological environment, there are cases in which the roles of Mg 2+ and Ca 2+ are antagonistic to each other. Calcium antagonists and their mode of action were described in 1986 [10]. Mg 2+ effects on the cell plasma membrane are shown by its competition with Ca 2+ from the CaATP molecule, its activation as MgATP of both the Ca 2+ -pump and the Na + -pump, and for the exchange of Na + against K + because the Na/K ATPase protein needs Mg 2+ and PO 4 3ions.…”

Section: Magnesium and Calcium Cellular Activitymentioning

confidence: 99%

Magnesium, calcium and cancer

Anghileri¹

2009

Magnesium Research

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Magnesium ion (Mg 2+ ) and calcium ion (Ca 2+ ) control a diverse and important range of cellular processes, such as gene transcription, cell proliferation, neoplastic transformation, immune response and therapeutic treatment. Their characteristic biologic antagonism makes it important to treat the most important aspects of that competitive behavior together. This synopsis aims to be a useful means of promoting further research on the relationship between both cations and human health affected by environmental conditions.

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Section: Magnesium and Calcium Cellular Activitymentioning

confidence: 99%

Magnesium, calcium and cancer

Anghileri¹

2009

Magnesium Research

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“…Calcium oxide (CaO) and calcium hydroxide (Ca(OH) 2 ) produced from limestone are readily available and important inorganic compounds used in various industries as adsorbents, toxic-waste remediation agents, and alkalization agents. However, both reagents contain harmful impurities, and CaO is especially dangerous, because it easily generates high heat in response to hydration [1,2]. Although scallop shells have been used as food additives and are a readily available source of CaO and Ca(OH) 2 , most are discarded as industrial waste.…”

Section: Introductionmentioning

confidence: 99%

Concentrated Bioshell Calcium Oxide (BiSCaO) Water Kills Pathogenic Microbes: Characterization and Activity

et al. 2020

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Bioshell calcium oxide (BiSCaO) exhibits deodorizing properties and broad microbicidal activity. In this study, we examined possible utility of BiSCaO Water for that purpose. BiSCaO Water was prepared by adding 10 wt% BiSCaO to clean water and gently collecting the supernatant in a bottle. The same volume of clean water was gently poured onto the BiSCaO precipitate and the supernatant was gently collected in a bottle; this process was repeated fifty times. The produced BiSCaO Water contained nanoparticles (about 400–800 nm) composed of smaller nanoparticles (100–200 nm), and was colorless and transparent, with a pH > 12.7. In vitro assays demonstrated that BiSCaO Water eliminated more than 99.9% of influenza A (H1N1) and Feline calicivirus, Escherichia coli such as NBRC 3972 and O-157:H7, Pseudomonas aeruginosa, Salmonella, and Staphylococcus aureus within 15 min. We compared BiSCaO Water with the other microbicidal reagents such as ethanol, BiSCaO, BiSCa(OH)2 suspensions, povidone iodine, NaClO, BiSCaO dispersion and colloidal dispersion with respect to deodorization activity and microbicidal efficacy. The results showed that BiSCaO Water was a potent reagent with excellent deodorization and disinfection activities against pathogenic bacteria and viruses (including both enveloped and nonenveloped viruses).

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“…Calcium is thought to play an important role in the regulation of physiological processes (Villereal and Palfrey, 1989;Wiercinski, 1989). A disturbance of the calcium homeostasis might be life threatening for cells (Schanne et al, 1979; Orrenius et al, 1989;Siesjo, 1989).…”

Section: 1993 Wiley-liss Incmentioning

confidence: 99%

Synergistic action of calcium‐lonophores and hyperthermia is best interpreted as thermal enhancement of calcium toxicity

Stege

Wierenga

Konings

et al. 1993

Journal Cellular Physiology

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It has been shown that no relation exists between [Ca2+]i and hyperthermic cell killing, although heat-induced increase of [Ca2+]i can be observed in some cell lines. When ionophores are used, dose-dependent rises in [Ca2+]i may be found. Beyond a certain threshold of ionophore-induced increases in [Ca2+]i, cells may be killed. Different threshold levels of [Ca2+]i exist in different cell lines. Hyperthermia can act synergistically with calcium ionophores to potentiate cell killing. Since there is no causal relation between [Ca2+]i and heat toxicity, this synergism can be explained as heat enhanced Ca2+ toxicity. In the current report, it is shown that both ionophore-induced Ca2+ toxicity (37 degrees C) and its potentiation by heat are dependent on extracellular calcium and related to sustained increases in [Ca2+]i. With ionomycin concentrations up to 15 microM, no increase in [Ca2+]i was seen in cells maintained in medium without Ca2+. Ionomycin effects on intracellular compartments were absent, and the drug seemed to act solely on the level of the plasmamembrane. Also, the synergism of heat and ionomycin appeared to act at the plasmamembrane, because depletion of extracellular calcium completely abolished this synergistic effect. The data presented are also discussed in the light of controversies existing in the literature for the role of calcium in hyperthermic cell killing.

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Calcium, An Overview—1989

Cited by 13 publications

References 166 publications

Magnesium, calcium and cancer

Magnesium, calcium and cancer

Concentrated Bioshell Calcium Oxide (BiSCaO) Water Kills Pathogenic Microbes: Characterization and Activity

Synergistic action of calcium‐lonophores and hyperthermia is best interpreted as thermal enhancement of calcium toxicity

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