Calcium and Magnesium in Male Reproductive System and in Its Secretion. I. Level in Normal Human Semen, Seminal Plasma and Spermatozoa

Valsa, James; Kp, Skandhan; Khan, P. Sahab; Avni, K.P.S.; Amith, S.; Gondalia, Meenaxi

doi:10.5301/urologia.5000039

Cited by 21 publications

(16 citation statements)

References 29 publications

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“…The magnesium concentration was more in sperm than in seminal plasma. 14,65 Magnesium was positively correlated with calcium concentration. 68 Functions of magnesium are several including its role in sperm motility.…”

Section: Discussionmentioning

confidence: 90%

“…Its level in semen, seminal plasma and spermatozoa in normal and infertile patients was measured. [11][12][13][14][15] The origin of these elements in man was located as mainly prostate gland. 1,2 Later on it was identified throughout the reproductive system.…”

Section: Introductionmentioning

confidence: 99%

“…Correlation was also seen between sperm calcium and sperm magnesium. 14 Considering the importance given to these electrolytes we carried out the present study where the level of these two electrolytes in 24 h after ejaculation was measured and correlated with total sperm count and motility.…”

Section: Introductionmentioning

confidence: 99%

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Time bound changes (in 24 h) in human sperm motility and level of calcium and magnesium in seminal plasma

Valsa

Skandhan

Sumangala

et al. 2016

Alexandria Journal of Medicine

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A detailed sperm motility study for 24 h after collection was done. The level of calcium and magnesium in seminal plasma during this period was also seen to understand the role of these electrolytes on sperm motility. Good care was taken in selection of subjects (young and healthy), collection and pre-physical analysis of sample. Subjects (healthy, 18-25 years) were to maintain abstinence (2-5 days). Collection of sample into wide mouthed container provided was done next to laboratory by masturbation at 8 am ± 30 m. The total study was done in one month period. Samples were studied at ½, 1, 2, 4, 8, 12 and 24 h time for percentage of (1) total sperm motility, (2) active and progressive and (3) non-progressive motility and seminal plasma calcium and magnesium. Total sperm motility deteriorated to 50% in 8 h whereas active and progressive type reduced to 50% in 4 h. At 24 h total sperm motility was 9.8% and active and progressive motility 3.0%. Level of calcium (27.2 mg/dl) and magnesium (13.54 mg/dl) in seminal plasma did not show any significant changes during study period from that of at ½ h. The study concluded that electrolytes under study were not responsible for the decrease in motility during study period.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Time bound changes (in 24 h) in human sperm motility and level of calcium and magnesium in seminal plasma

Valsa

Skandhan

Sumangala

et al. 2016

Alexandria Journal of Medicine

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“…The expression level of CIB1 was highest in normal testicular tissue, and participated in calcium signaling, cell survival and proliferation, cell migration, cell adhesion and apoptosis [22,23]. CIB1 could regulate the release of intracellular Ca 2+ , the calcium ion signal had special signi cance in the sperm cells, and it was the central regulator factor of many key activities, which included capacitation, superactivation, chemotaxis and acrosome reaction [24,25]. The damage of calcium ion signal in sperm was related to male sterility [26].…”

Section: Discussionmentioning

confidence: 99%

Proteome Analysis of Testicular Tissue in Varicocele Rats Using iTRAQ Labeling Technology

feng

Zhao

rong

et al. 2020

Preprint

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Purpose Varicocele (VC) is considered as the main cause of male infertility, clear and definite molecular markers of varicocele disease are helpful for early prevention and timely treatment. This study was in order to examine the effect of varicocele on protein expression in testicular tissue.Methods The testicular tissue samples of normal rats and varicocele rats were used for proteomic analysis and functional bioinformatics analysis. The proteins with a fold change of > 1.2 or < 1.2, and with a P-value < 0.05 were used to identify up- and downregulation proteins between the varicocele and control rats, and two target proteins were selected and verified with western blot.Results It was found that seminiferous epithelium was disordered and spermatogenic cells were injured seriously in varicocele group. A total of 65 differentially expressed proteins were identified compared with normal group by liquid chromatography tandem mass spectrometry (LC-MS/MS) and isobaric tags for relative and absolute quantitation (iTRAQ) analysis, including 31 up-regulated proteins and 34 down-regulated proteins, respectively. Functions of those proteins were mainly related to the following processes: signal transduction, protein cycle, transmembrane transport, protein transport, vesicular mediated transport, cell division, and membrane tissue. Two down regulated proteins of ATPase and Cu2+-transporting alpha (ATP7A) and Calcium and integrin-binding protein 1 (CIB1) in varicocele rats were selected and confirmed.Conclusion Protein spectrum of testicular tissue in varicocele rats was different from that in normal rats. Low expressions of ATP7A and CIB1 may be affect testicular spermatogenic function and can be used as a potential biomarker for testicular tissue to maintain normal spermatogenic function.

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“…Calcium and magnesium are the best examples. 1,18 Zinc is rich in semen and is mainly contributed by prostate gland. 1,2,9 Gold is discovered in human semen in 1981.…”

Section: Discussionmentioning

confidence: 99%

Gold in semen: Level in seminal plasma and spermatozoa of normal and infertile patients

Valsa

Sumangala

et al. 2017

Alexandria Journal of Medicine

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The study was conducted to understand the amount of gold in semen of normal and different infertile conditions. Gold was estimated in normal (n38) and pathological conditions (n86) by employing Atomic Absorption Spectrophotometer. Gold level observed in seminal plasma was as follows: in normozoospermia (n38)-17.0 lg% ± 9.63; oligozoospermia (n23)-13.0 lg% ± 0.73; oligoasthenozoospermia (n44)-20.5 lg%5 ± .58 and in azoospermia (n19) 21.5 lg% ± 7.52. Gold level in sediment (spermatozoa) of normal was almost same as observed in its seminal plasma whereas in oligozoospermia and oligoasthenozoospermia the level was low.

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Calcium and Magnesium in Male Reproductive System and in Its Secretion. I. Level in Normal Human Semen, Seminal Plasma and Spermatozoa

Cited by 21 publications

References 29 publications

Time bound changes (in 24 h) in human sperm motility and level of calcium and magnesium in seminal plasma

Time bound changes (in 24 h) in human sperm motility and level of calcium and magnesium in seminal plasma

Proteome Analysis of Testicular Tissue in Varicocele Rats Using iTRAQ Labeling Technology

Gold in semen: Level in seminal plasma and spermatozoa of normal and infertile patients

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