Calcium and Phosphorus Metabolism in Thyrotoxicosis

Beaumont, G; Dodds, E. C.; Robertson, J. D.

doi:10.1677/joe.0.0020237

Cited by 14 publications

(3 citation statements)

References 6 publications

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“…A loss of skeletal calcium due to a disturbance of the gastro-intestinal tract and kidney would be expected to cause osteomalacia with a lowered level of serum phosphorus. These pathologic and chemical changes have not been observed (3,(22)(23)(24).…”

Section: Serum Calcium and Phosphorus Levelsmentioning

confidence: 95%

“…(Table 1, periods 4 and 5). Beaumont, Dodds and Robertson found excessive losses of calcium in 18 of 33 hyperthyroid patients (22).…”

Section: Serum Calcium and Phosphorus Levelsmentioning

confidence: 95%

“…However, in the great majority of thyrotoxic subjects there is no elevation of the serum calcium level (3,6,22,23,25) despite osseous losses which can increase the urinary excretion of calcium to values of 1 Gm. daily (3).…”

Section: Serum Calcium and Phosphorus Levelsmentioning

confidence: 99%

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Metabolic Observations in a Case of Thyrotoxicosis With Hypercalcemia*

Kleeman¹,

Tuttle²,

Bassett³

1958

The Journal of Clinical Endocrinology & Metabolism

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Hyperthyroidism characteristically causes excessive urinary and fecal excretion of calcium and, rarely, hypercalcemia. These abnormalities were studied in a 58-ycar-old thyrotoxic male. The investigation consisted of a 125-day balance study as the patient became euthyroid and a similar 50-day balance study during a recurrence of the thyrotoxicosis. The excessive urinary and fecal loss of calcium bore little relationship to the calcium or caloric content of the diet or to the level of nitrogen balance. A high phosphate diet ameliorated the metabolic abnormality and corrected the hypercalcemia. Successful treatment of the thyrotoxicosis produced similar changes in calcium metabolism. Hypercalcemia was not present during recurrence of the thyrotoxicosis.The metabolic observations in this case and those previously reported strongly suggest that the excessive urinary and fecal excretion of calcium in thyrotoxicosis is due to a direct effect of thyroid hormone on osseous metabolism. The hypercalcemia is probably secondary to a disorder in the homeostatic mechanism(s) regulating the content of ionized calcium in the extracellular fluid.

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Section: Serum Calcium and Phosphorus Levelsmentioning

confidence: 95%

“…(Table 1, periods 4 and 5). Beaumont, Dodds and Robertson found excessive losses of calcium in 18 of 33 hyperthyroid patients (22).…”

Section: Serum Calcium and Phosphorus Levelsmentioning

confidence: 95%