Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial

Greene, David; Naughton, Géraldine

doi:10.1007/s00198-010-1317-z

Cited by 40 publications

(21 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whereas studies in adult and those in older children corroborate these findings [22, 24, 28, 32–34], previous investigations have observed that processes underlying skeletal strength may be most sensitive to mechanical strain at this critical stage [3, 6, 28]. It is estimated that the first three weeks of bone remodelling involve resorption processes, while an additional 12 weeks is necessary to complete deposition of mineral matrix.…”

Section: Resultsmentioning

confidence: 85%

“…Physical activity represents an extrinsic factor that impacts both mineral accretion and BMAT, exerting permissive capacity of the growing skeleton to achieve its full genetic potential [24]. In accordance with the consistent reports of the beneficial effects of physical activity on bone deposition in children [25–30], we hypothesized that in this moderate-intensity weight-bearing physical activity intervention during a critical period of growth and development would result in augmentation of material properties of bone in terms of mineral deposition and femoral marrow cavity volume.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Short-term physical activity intervention decreases femoral bone marrow adipose tissue in young children: A pilot study

Casazza

Hanks

Hidalgo

et al. 2012

Bone

View full text Add to dashboard Cite

Mechanical stimulation is necessary for maximization of geometrical properties of bone mineralization contributing to long-term strength. The amount of mineralization in bones has been reciprocally related to volume of bone marrow adipose tissue and this relationship is suggested to be an independent predictor of fracture. Physical activity represents an extrinsic factor that impacts both mineralization and marrow volume exerting permissive capacity of the growing skeleton to achieve its full genetic potential. Because geometry- and shape-determining processes primarily manifest during the linear growth period, the accelerated structural changes accompanying early childhood (ages 3 to 6 y) may have profound impact on lifelong bone health. The objective of this pilot study was to determine if a short-term physical activity intervention in young children would result in augmentation of geometric properties of bone. Three days per week the intervention group (n=10) participated in 30 minutes of moderate intensity physical activity, such as jumping, hopping and running, and stretching activities, whereas controls (n=10) underwent usual activities during the 10-week intervention period. Femoral bone marrow adipose tissue volume and total body composition were assessed by magnetic resonance imaging and dual-energy X-ray absorptiometry, respectively, at baseline and after ten weeks. Although after 10-weeks, intergroup differences were not observed, a significant decrease in femoral marrow adipose tissue volume was observed in those participating in physical activity intervention. Our findings suggest physical activity may improve bone quality via antagonistic effects on femoral bone marrow adipose tissue and possibly long-term agonistic effects on bone mineralization.

show abstract

Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Short-term physical activity intervention decreases femoral bone marrow adipose tissue in young children: A pilot study

Casazza

Hanks

Hidalgo

et al. 2012

Bone

View full text Add to dashboard Cite

show abstract

“…A randomized controlled vitamin D plus calcium supplementation trial in peripubertal female identical twins (n=20; ages 9 to 13 years) showed a more positive impact on bone outcomes [24]. One of each pair was randomized to receive 800 mg of calcium and 400 IU of cholecalciferol, or placebo for 6 months.…”

Section: Nutrition and Bonementioning

confidence: 99%

Quantitative Computed Tomography and Computed Tomography in Children

Zemel

2011

Curr Osteoporos Rep

View full text Add to dashboard Cite

Quantitative computed tomography (QCT) methodologies have been instrumental in deepening our understanding of bone acquisition and strength during childhood. Important publications in the last year have drawn attention to the functional muscle-bone unit, showing that factors such as population ancestry, bone size, and muscle composition are additional dimensions of bone strength that affect muscle-bone relationships. The role of adiposity in pediatric bone health is complex and may vary by sex, puberty stage, and degree of obesity. Several new studies have demonstrated the association of peripheral QCT (pQCT) outcomes with fracture, although pQCT outcomes are not superior to dual-energy x-ray absorptiometry measures in this regard. New high-resolution pQCT studies document transient weakness in mid-puberty that coincides developmentally with the period of peak fracture incidence. These new studies will ultimately help us understand the development of sex differences in bone strength that emerge in adolescence.

show abstract

“…Prevalence of AN is highest among adolescents; sufficient calcium intake during the second decade of life is critical to maximize skeletal growth during the pubertal growth spurt 4,65 and help decrease fracture risk during adulthood. 66 According recent guidelines from the Institute of Medicine, the recommended dietary allowance per day for calcium is 700 mg for children 1-3 years old; 1,000mg for 4-8 years old; 1,300mg for 9-18 years old; 1,000 for 19-70 years old; and 1,200 for 70 years and older.…”

Section: Treatment Considerationsmentioning

confidence: 99%

Skeletal complications of eating disorders

Donaldson

Gordon

2015

Metabolism

View full text Add to dashboard Cite

Anorexia Nervosa (AN) is a psychiatric illness with profound medical consequences. Among the many adverse physical sequelae of AN, bone health is impacted by starvation and can be permanently impaired over the course of the illness. In this review of skeletal complications associated with eating disorders, we discuss the epidemiology, neuroendocrine changes, adolescent vs. adult skeletal considerations, orthopedic concerns, assessment of bone health, and treatment options for individuals with AN. The focus of the review is the skeletal sequelae associated with anorexia nervosa, but we also briefly consider other eating disorders that may afflict adolescents and young adults. The review presents updates to the field of bone health in AN, and also suggests knowledge gaps and areas for future investigation.

show abstract

Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial

Abstract: Daily supplementation for a period of 6 months was associated with increased trabecular area, trabecular density and strength strain index at the ultra-distal tibia and radius and increased cortical area at tibial mid-shaft.

Cited by 40 publications

References 30 publications

Short-term physical activity intervention decreases femoral bone marrow adipose tissue in young children: A pilot study

Short-term physical activity intervention decreases femoral bone marrow adipose tissue in young children: A pilot study

Quantitative Computed Tomography and Computed Tomography in Children

Skeletal complications of eating disorders

Contact Info

Product

Resources

About