Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea-pig

Dar, Ahsana; Channa, Shabana

doi:10.1016/s0378-8741(98)00240-2

Cited by 77 publications

(52 citation statements)

References 17 publications

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“…As for the SE, although it caused a significant inhibition at the highest dose used, it did not produce a consistent dose-response pattern. It has been well established that the spontaneous contraction of the intestinal smooth muscle is due to cycles of depolarisation involving a fast influx of Ca can occur either via influx of the ion through the voltage-operated calcium channel (VOCC) or release of calcium from sarcoplasmic reticulum (McDonald et al, 1994;Elorriaga et al, 1996;Bolton et al, 1999;Dar and Channa, 1999). The frequency of the contractions was not altered by any of the test substances suggesting that they do not modify the frequency of the spontaneous depolarisation from the pacemaker cells.…”

Section: Discussionmentioning

confidence: 99%

Spasmolytic effect of citral and extracts of Cymbopogon citratus on isolated rabbit ileum

Devi

Sim

Ismail

2011

J Smooth Muscle Res

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Cymbopogon citratus, commonly known as lemongrass, has been shown to have antioxidant, antimicrobial and chemo-protective properties. Citral, a monoterpenoid, is the major constituent of C. citratus that gives off a lemony scent and is postulated to be responsible for most of its actions. In addition, C. citratus has been traditionally used to treat gastrointestinal discomforts, however, the scientific evidence for this is still lacking. Thus, the aim of the present study was to investigate the effect of the extracts of various parts of C. citratus (leaves, stems and roots) and citral on the visceral smooth muscle activity of rabbit ileum. The effect of the test substances were tested on the spontaneous contraction, acetylcholine (ACh)-and KCl-induced contractions. Citral at doses between 0.061 mM to 15.6 mM and the extract of leaves at doses between 0.001 mg/mL to 1 mg/mL significantly reduced the spontaneous, ACh-and KCl-induced ileal contractions. When the ileum was incubated in K + -rich-Ca 2+ -free Tyrode's solution, it showed only minute contractions. However, the strength of contraction was increased with the addition of increasing concentrations of CaCl2. The presence of citral almost abolished the effect of adding CaCl2, while the leaf extract shifted the calcium concentration-response curve to the right, suggesting a calcium antagonistic effect. These results were similar to that elicited by verapamil, a known calcium channel blocker. In addition, the spasmolytic effect of citral was observed to be reduced by the nitric oxide synthase inhibitor, L-NAME. In conclusion, citral and the leaf extract of C. citratus exhibited spasmolytic activity and it appeared that they may act as calcium antagonists. Furthermore, the relaxant effect of citral, but not that of the leaf extract may be mediated by nitric oxide suggesting the presence of other chemical components in the leaf extract other than citral.

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Section: Discussionmentioning

confidence: 99%

Spasmolytic effect of citral and extracts of Cymbopogon citratus on isolated rabbit ileum

Devi

Sim

Ismail

2011

J Smooth Muscle Res

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“…These effects possibly mediated by inhibition of calcium-ion influx into cell membranes [47][48][49]. The methanol extract of Bacopa possessed potent mast cell stabilizing activity comparable to disodium cromoglycate [50][51].…”

Section: Bacopa Monnierimentioning

confidence: 99%

A Review of Medicinal Plants with Broncho-Dilatory Effect-Part 1

Al-Snafi¹

2016

SAJP

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“…Bacopa extract has proven sedative (Malhotra and Das 1959), anti-inflammatory and antipyretic (Jain et al 1994), anti-cancer (Elangovan et al 1995), anti-oxidant (Tripathi et al 1996;Sumathy et al 2001), immuno-modulatory (Dahanukar and Thatte 1997), anxiolytic (Bhattacharya and Ghosal 1998), antihelminthic (Renukappa et al 1999), antiulcerogenic (Rao et al 2000), anti allergic (Samiulla et al 2001, antistress (adaptogenic) (Chowdhuri et al 2002;Rai et al 2003), anti-leishmanial (Sinha et al 2002), antidepressant (Sairam et al 2002: Zhou et al 2007 antipyretic, analgesic and sedative (Kishore and Singh 2005) and anti aging properties (Sharma et al 2010). The plant has been used in Ayurvedic system of Indian medicine as diuretic, aperitive and cardiotonic (Basu and Walia 1944), revitaliser of sensory organs (Chopra et al 1969: Sivarajan andBalachandran 1994), water retention and blood cleaning (Singh and Dhawan 1982), relaxant (Dar and Channa 1997) calcium antagonistic (Dar and Channa 1999), short and long term learning effect (Lodha and Bagga 2000), neuroprotective (Jyoti and Sharma 2006), It is also used as astringent, appetizer, and soft laxative. The wonder plant is also used to treat allergic disorders of skin, enlargement of the spleen, snake bite, rheumatism, and leprosy (Basu and Walia 1944).…”

Section: Distribution and Usesmentioning

confidence: 99%

Genetic variation among highly endangered Bacopa monnieri (L.) Pennell from Southern India as detected using RAPD analysis

Karthikeyan

Madhanraj

Pandian

et al. 2011

Genet Resour Crop Evol

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Randomly amplified polymorphic DNA (RAPD) fingerprinting approach was applied to assess genetic diversity in different accessions of rejuvenating and intellect-promoting ancient ayurvedic medicinal herb Bacopa monnieri (L.) Pennell collected from four Southern Indian states, along with in vitro micropropagated samples maintained in the laboratory for 5 years. With the 10 analyzed primers, 110 distinct bands, in the size range of 250-870 bp were observed, and among which 14 (12.72%) were polymorphic. Among the random primers used, only OPD 02 generated highest percentage of polymorphism with 30.77. Whereas OPD 08 generated a maximum of 18 amplified bands, but with only 1% polymorphism. Cluster analysis done on the basis of similarity co-efficient generated from RAPD profiles indicated all the accessions were divided into two sub-groups based on genetic distances under one major cluster. Major cluster is only the lone loose group of the Bm.2 collected from Kerala (KER) and in vitro micropropagated plant (IVMP) maintained in the lab. The other sub-group consisted of Bm.1 and Bm.3 collected from Tamil Nadu (TN) and Andhra Pradesh (AP) respectively, which are genetically similar and showed similarity with accessions from Karnataka Bm.4 (KK). These two sub-groups were joined together at 0.66 genetic distance level. Overall, the levels of genetic similarity within the accessions varied from 0.24 to 0.80, the matrix ranged from 0.36 to 0.80, with a mean value of 0.68 indicating genetic similarity at low level.

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Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea-pig

Cited by 77 publications

References 17 publications

Spasmolytic effect of citral and extracts of Cymbopogon citratus on isolated rabbit ileum

Spasmolytic effect of citral and extracts of Cymbopogon citratus on isolated rabbit ileum

A Review of Medicinal Plants with Broncho-Dilatory Effect-Part 1

Genetic variation among highly endangered Bacopa monnieri (L.) Pennell from Southern India as detected using RAPD analysis

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