Calcium carbonate nanoparticles tumor delivery for combined chemo-photodynamic therapy: Comparison of local and systemic administration

Yakubova, Aziza; Mitusova, K. A.; Darwish, Aya; Rogova, Anna; Ageev, Eduard; Brodskaia, Aleksandra V.; Muslimov, Аlbert R.; Zyuzin, Mikhail V.; Timin, Alexander S.

doi:10.1016/j.jconrel.2023.06.012

Cited by 10 publications

(3 citation statements)

References 61 publications

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“…In our previous study, we found that locally injected MSCs did not migrate into other tissue, and the majority of injected cells stayed within injected tissue [ 56 ]. In another published paper, researchers showed that fluorescence-labeled nanoparticles were detected in several major tissues in intravenous injection, while they were only detected in tumor tissue in intratumor local injection [ 57 ]. Based on those published papers, we assume that the higher efficacy of intravenous injection in metabolic regulation is due to the higher distribution rate of injected exosomes to the liver and adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles to Treat PCOS

Park

Çetin

Siblini

et al. 2023

IJMS

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Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in women. Previously, we suggested that human mesenchymal stem cells (MSCs) can reverse the PCOS condition by secreting factors. Here, we evaluated the therapeutic capability of MSC-derived extracellular vesicles (EVs), also known as exosomes, in both in vitro and in vivo PCOS models. Exosomes were used to treat androgen-producing H293R cells and injected in a mouse model through intraovarian and intravenous injection into a letrozole (LTZ)-induced PCOS mouse model. We assessed the effects of the exosomes on androgen-producing cells or the PCOS mouse model by analyzing steroidogenic gene expression (quantitative real-time polymerase chain reaction (qRT–PCR)), body weight change, serum hormone levels, and fertility by pup delivery. Our data show the therapeutic effect of MSC-derived EVs for reversing PCOS conditions, including fertility issues. Interestingly, intravenous injection was more effective for serum glucose regulation, and an intraovarian injection was more effective for ovary restoration. Our study suggests that MSC-derived exosomes can be promising biopharmaceutics for treating PCOS conditions as a novel therapeutic option. Despite the fact that we need more validation in human patients, we may evaluate this novel treatment option for PCOS with the following clinical trials.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles to Treat PCOS

Park

Çetin

Siblini

et al. 2023

IJMS

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“…Research showed that the therapy with Ce6/Dox@CaCO 3 and light irradiation caused melanoma tumors in mice to shrink by approximately 94% for intratumoral injection and by 71% for intravenous injection with a significantly synergistic antitumor effect. 23…”

Section: Combining Phototherapy With Chemotherapymentioning

confidence: 99%

Advances and perspectives in phototherapy-based combination therapy for cancer treatment

Yi,

Liu,

Gao

et al. 2024

J. Mater. Chem. B

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“…By elevating the temperature of tumor tissues, PTT can selectively target and eliminate primary tumors . PDT is a targeted therapeutic approach that utilizes photosensitizers, which are activated by specific wavelengths of light to produce ROS, ultimately leading to tumor cell death. , PTT and PDT have been employed for the treatment of diverse cancers, including melanoma, lung cancer, breast cancer, etc. ,− However, tumor cells may produce SerpinB9 to suppress granzyme B activity, thereby reducing the efficacy of phototherapy. Therefore, overcoming SerpinB9-mediated resistance is the key to improving the effectiveness of phototherapy.…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Titania Nanoparticle-Based Photoimmunotherapy via Tumor-Microenvironment-Responsive Gene Editing of SerpinB9 for Triple-Negative Breast Cancer

Yang,

Zhang,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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Triple-negative breast cancer (TNBC) is a heterogeneous disease with multiple biological subtypes, offering poor clinical outcomes. No targeted therapy was approved for TNBC due to lack of tumor-specific targets. Here, we identify SerpinB9 as a vulnerability target for immunomodulatory TNBC tumors, suggesting that gene editing of SerpinB9 via the CRISPR/Cas9 system may be a viable approach to immunomodulatory TNBC-targeted therapy. To increase bioavailability and improve the delivery efficiency of gene editing, we designed glutathione-responsive nanoparticles to deliver Cas9 ribonucleoprotein targeting SerpinB9 (TiO 2−x @Cas9-RNP@HA). Under near-infrared light irradiation, TiO 2−x can produce both photodynamic therapy (PDT) and photothermal therapy (PTT) effects. PTT can induce tumor cell ablation and immunogenic cell death. PDT can produce ROS to induce cell killing and downregulation of SerpinB9. Inhibition of SerpinB9 expression with nanoparticles (TiO 2−x @Cas9-RNP@ HA) combined with near-infrared titania phototherapy can synergistically inhibit tumor growth. These results demonstrate the potential of near-infrared titania nanoparticle-based phototherapy and precise SerpinB9-targeted therapies in immunomodulatory TNBCs.

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Calcium carbonate nanoparticles tumor delivery for combined chemo-photodynamic therapy: Comparison of local and systemic administration

Cited by 10 publications

References 61 publications

Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles to Treat PCOS

Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles to Treat PCOS

Advances and perspectives in phototherapy-based combination therapy for cancer treatment

Near-Infrared Titania Nanoparticle-Based Photoimmunotherapy via Tumor-Microenvironment-Responsive Gene Editing of SerpinB9 for Triple-Negative Breast Cancer

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