Calcium content of the endoplasmic reticulum of snail neurones releasable by caffeine

Thomas, R C

doi:10.1016/j.ceca.2012.10.007

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…These receptors cause a rapid Ca 2+ leakage from SR/ER, increasing Ca 2+ in the cytosol, and triggering a series of signaling processes. Caffeine is an activator of ryanodine ER receptors, and its activation causes Ca 2+ release from ER [34]. In turn, it is known that ER disfunction can promote a number of disorders of nervous system [35].…”

Section: Discussionmentioning

confidence: 99%

Effect of caffeine and coffee diets on calcium signalling in rat hippocampal neurons

Shkryl¹,

Turitska²,

Yavorsky³

et al. 2021

Fiziol Zh

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The effects of long-lasting high concentration coffee and caffeine diets on calcium mobilization in rat hippocampal neurons were studied. Changes in the basal calcium level in the hippocampal neurons of control and experimental rats kept on a coffee or caffeine diet were measured. We also recorded the changes in the Ca2+ transients’ amplitude evoked by membrane depolarization or emptying the Ca2+ depot of the endoplasmic reticulum (ER) induced by caffeine activator of the ryanodine receptors. In rats on a coffee or caffeine diet, the basal Ca2+ level was increased by 7.4% and 11%, respectively, compared to control animals. In these groups, the amplitude of Ca2+ transients increased by 70% and 90%, respectively, of the basal level in response to the membrane depolarization. In the same groups, the amount of Ca2+ released from the ER was increased by two and three times, respectively, compared to the control after activation of ryanodine receptors. We concluded that long-term coffee and caffeine diets in rats cause a significant disruption of the hippocampal neurons’ endoplasmic reticulum function. The diets evoke an increase in Ca2+ concentration in the neurons and an excessive release of Ca2+ in response to excitation. The latter can lead to increased excitability of neurons and their further death from excessive Ca2+ levels.

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Section: Discussionmentioning

confidence: 99%

Effect of caffeine and coffee diets on calcium signalling in rat hippocampal neurons

Shkryl¹,

Turitska²,

Yavorsky³

et al. 2021

Fiziol Zh

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show abstract

“…From the toxicological point of view, caffeine may paralyze or kill some insect species. It was also found that caffeine may be used as a neural poison against gastropods (Thomas 2013). The effect of caffeine on spiders was also confirmed (Hesselberg and Vollrath 2004).…”

Section: Introductionmentioning

confidence: 85%

Antifungal activity of methylxanthines based on their properties

Kobetičová

Nábělková

Ďurišová

et al. 2020

BioRes

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Wood materials for construction purposes can be attacked by various wood-destroying fungi. An ideal wood-preserving substance is supposed to be environment- and health-friendly. For this reason, the effects of the most relevant and non-toxic methylxanthines, such as caffeine and its metabolites theobromine and theophylline, on fungal growth, together with their degradability related to their properties were analyzed in this study. Agar tests with four wood-destroying fungal species (Serpula lacrymans, Coniophora puteana, Gleophyllum sepiarium, and Trametes versicolor) were performed after 28 days of substance exposure. Caffeine exhibited a 100% inhibitive effect on fungal growth, contrary to theobromine, which was not effective in that respect. Theophylline exhibited variable effects on the analyzed fungi. The analysis of degradability indicated the persistence of caffeine and theobromine, but theophylline was degraded up to 34%. The relation of toxicity to chemical structure of studied methylxanthines indicated the dipole moment and lipophilicity as important parameters affecting the antifungal properties. Both caffeine and theophylline are suitable potential candidates for antifungal active substances.

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“…Para explorar el efecto opuesto, se aprovechó el uso de la solución salina cafeína ocacionando la liberación de Ca +2 de los compartimientos intracelulares y de esta forma la perturbación de su regulación [33,34]. Con esto se encontró como primer resultado un incremento en la frecuencia de aparición del potencial de acción.…”

Section: Análisis Del Intervalo Interespiga (Isi)unclassified

“…Se ha reportado que 100 µM de CdCl 2 bloquea el 60 % de la corriente de Ca +2 en las neuronas de H. aspersa[32].En otro experimento, el registro intracelular inició después de 30 s de perfusión con solución salina normal, y tuvo una duración de 10 min; posteriormente, el ganglio fue perfundido con solución salina cafeína después de 20 s y tuvo una duración de 5 min. Se reconoce que la cafeína permite la liberación de Ca +2 de los compartimientos intracelulares (retículo endoplasmático)[33,34]. En la figura 9 se muestra la secuencia de estos experimentos.De forma similar, con la herramienta DFA se estudió el cambio en la dinámica de las fluctuaciones de voltaje en el segmento interespiga con respecto al tiempo, a través de una ventana móvil de 1500 muestras con el fin de estimar las variaciones del exponente de escalamiento α(t)[23].…”

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Estudio de la dinámica de las fluctuaciones del potencial de membrana y su relación con la actividad neuronal de tipo marcapaso

Rubfiaro

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Calcium content of the endoplasmic reticulum of snail neurones releasable by caffeine

Cited by 5 publications

References 23 publications

Effect of caffeine and coffee diets on calcium signalling in rat hippocampal neurons

Effect of caffeine and coffee diets on calcium signalling in rat hippocampal neurons

Antifungal activity of methylxanthines based on their properties

Estudio de la dinámica de las fluctuaciones del potencial de membrana y su relación con la actividad neuronal de tipo marcapaso

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